SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5csc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		5 / 12 ALA B 414
LEU B  13
THR B  55
LEU B  95
ALA B 407
 None
 1.11A 1ao8A-5cscB:
undetectable		 1ao8A-5cscB:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		4 / 8 MET B 176
PHE B  93
THR B  98
LEU B  10
 None
 1.26A 1ea1A-5cscB:
undetectable		 1ea1A-5cscB:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		4 / 6 ASP B 327
ASP B 375
ASN B 278
GLU B 335
 None
 1.27A 1rjdA-5cscB:
undetectable		 1rjdA-5cscB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		4 / 6 ASP B 327
ASP B 375
ASN B 278
GLU B 335
 None
 1.27A 1rjdB-5cscB:
undetectable		 1rjdB-5cscB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		4 / 6 ASP B 327
ASP B 375
ASN B 278
GLU B 335
 None
 1.22A 1rjdC-5cscB:
undetectable		 1rjdC-5cscB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		4 / 7 ILE B 200
LEU B 120
ASN B 192
ILE B 189
 None
 0.94A 1yc2E-5cscB:
undetectable		 1yc2E-5cscB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		5 / 12 LEU B 128
LEU B 120
ILE B 145
LEU B 178
TYR B 392
 None
 1.12A 2oipA-5cscB:
undetectable		 2oipA-5cscB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		5 / 12 LEU B 128
LEU B 120
ILE B 145
LEU B 178
TYR B 392
 None
 1.16A 2oipD-5cscB:
undetectable		 2oipD-5cscB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		5 / 12 LEU B 128
LEU B 120
ILE B 145
LEU B 178
TYR B 392
 None
 1.11A 2oipE-5cscB:
undetectable		 2oipE-5cscB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		3 / 3 LEU B  92
PRO B  89
ARG B 329
 None
 0.63A 2qd5A-5cscB:
undetectable		 2qd5A-5cscB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		4 / 8 TYR B 231
LEU B 282
VAL B 281
LEU B 285
 None
 0.88A 2w98B-5cscB:
undetectable		 2w98B-5cscB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		5 / 12 THR B  55
GLY B  99
LEU B  95
LEU B   6
GLU B  17
 None
 1.18A 2zw9B-5cscB:
undetectable		 2zw9B-5cscB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		5 / 12 LEU B 128
LEU B 120
ILE B 145
LEU B 178
TYR B 392
 None
 1.08A 3hj3D-5cscB:
undetectable		 3hj3D-5cscB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		4 / 7 TYR B 392
MET B 228
LEU B 396
PHE B 213
 None
 1.29A 3nk2X-5cscB:
undetectable		 3nk2X-5cscB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		5 / 12 LEU B 128
LEU B 120
ILE B 145
LEU B 178
TYR B 392
 None
 1.10A 4q0dA-5cscB:
undetectable		 4q0dA-5cscB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		5 / 12 LEU B 128
LEU B 120
ILE B 145
LEU B 178
TYR B 392
 None
 1.09A 4q0dB-5cscB:
undetectable		 4q0dB-5cscB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		5 / 12 LEU B 128
LEU B 120
ILE B 145
LEU B 178
TYR B 392
 None
 1.09A 4q0dE-5cscB:
undetectable		 4q0dE-5cscB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		4 / 8 ALA B 245
SER B 248
SER B 412
ALA B 407
 None
 0.68A 4twdF-5cscB:
undetectable
4twdG-5cscB:
undetectable
4twdH-5cscB:
undetectable
4twdI-5cscB:
undetectable
4twdJ-5cscB:
undetectable		 4twdF-5cscB:
19.69
4twdG-5cscB:
19.69
4twdH-5cscB:
19.69
4twdI-5cscB:
19.69
4twdJ-5cscB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		4 / 4 ALA B 414
PRO B 418
LEU B 250
HIS B 249
 None
 1.40A 5eskA-5cscB:
undetectable		 5eskA-5cscB:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		5 / 8 VAL B 350
LEU B 353
TRP B 284
GLY B 317
ALA B 376
 None
 1.40A 5f1aA-5cscB:
undetectable		 5f1aA-5cscB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		4 / 5 ILE B 234
ARG B 329
CYH B 332
GLU B 335
 None
 1.27A 5fseC-5cscB:
undetectable		 5fseC-5cscB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		4 / 5 ILE B 234
GLN B  75
CYH B 332
GLU B 335
 None
 1.47A 5fseC-5cscB:
undetectable		 5fseC-5cscB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		5 / 12 LEU B 403
ALA B 402
ILE B 200
MET B 216
LEU B 120
 None
 1.01A 5h8tA-5cscB:
undetectable		 5h8tA-5cscB:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		5 / 12 LEU B 403
ALA B 402
ILE B 200
MET B 216
LEU B 120
 None
 1.01A 5hbsA-5cscB:
undetectable		 5hbsA-5cscB:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		4 / 6 GLY B 386
THR B 388
TYR B 190
TYR B 219
 None
 1.05A 6ag0C-5cscB:
undetectable		 6ag0C-5cscB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		3 / 3 GLY B 386
THR B 388
GLU B 389
 None
 0.65A 6b58A-5cscB:
undetectable		 6b58A-5cscB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		3 / 3 ARG B 401
HIS B 235
ARG B 329
 None
 1.17A 6dwdD-5cscB:
undetectable		 6dwdD-5cscB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		5 / 11 SER B 142
VAL B 251
SER B 412
ALA B 414
VAL B 405
 None
 1.13A 6hu9A-5cscB:
undetectable
6hu9E-5cscB:
undetectable
6hu9I-5cscB:
undetectable		 6hu9A-5cscB:
21.54
6hu9E-5cscB:
17.16
6hu9I-5cscB:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		5 / 10 SER B 142
VAL B 251
SER B 412
ALA B 414
VAL B 405
 None
 1.16A 6hu9L-5cscB:
undetectable
6hu9P-5cscB:
undetectable
6hu9T-5cscB:
undetectable		 6hu9L-5cscB:
21.54
6hu9P-5cscB:
17.16
6hu9T-5cscB:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		4 / 5 HIS B 238
ARG B 329
PHE B 397
ARG B 401
 None
 0.55A 6hxiB-5cscB:
14.2		 6hxiB-5cscB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		5 / 5 HIS B 238
ARG B 329
ASP B 375
PHE B 397
ARG B 401
 None
 0.64A 6hxiD-5cscB:
15.2		 6hxiD-5cscB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		4 / 4 HIS B 249
LEU B 255
TYR B 167
GLY B 416
 None
 1.20A 6n91A-5cscB:
undetectable		 6n91A-5cscB:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		 5csc CITRATE SYNTHASE
(Gallus
gallus) 		4 / 4 HIS B 249
LEU B 255
TYR B 167
GLY B 416
 None
 1.19A 6n91B-5cscB:
undetectable		 6n91B-5cscB:
12.32