SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5csl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 508
LEU A 527
LEU A 530
LEU A 475
 None
 1.17A 1a4lD-5cslA:
2.2		 1a4lD-5cslA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 THR A1229
LEU A1183
VAL A1186
LEU A1190
 None
 0.92A 1fbmB-5cslA:
undetectable		 1fbmB-5cslA:
2.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 MET A1564
SER A1732
PHE A1596
ALA A1623
 None
 1.22A 1fxvA-5cslA:
undetectable
1fxvB-5cslA:
undetectable		 1fxvA-5cslA:
7.37
1fxvB-5cslA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 884
LEU A 907
ILE A 847
VAL A 866
PHE A 876
 None
 0.97A 1gx8A-5cslA:
undetectable		 1gx8A-5cslA:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 527
LEU A 547
ILE A 532
LEU A 562
VAL A 321
 None
 1.23A 1hrkA-5cslA:
2.4		 1hrkA-5cslA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 323
ASP A 503
SER A 502
ASN A 124
 None
 1.40A 1kiaB-5cslA:
2.7		 1kiaB-5cslA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 323
ASP A 503
SER A 502
ASN A 124
 None
 1.41A 1kiaC-5cslA:
2.4		 1kiaC-5cslA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 THR A1229
LEU A1183
VAL A1186
LEU A1190
 None
 0.88A 1mz9D-5cslA:
undetectable		 1mz9D-5cslA:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A1861
ILE A1820
GLY A1886
GLU A1575
ALA A1882
 None
 1.00A 1nv8B-5cslA:
2.7		 1nv8B-5cslA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A1939
ALA A1935
ILE A1949
ILE A1974
 None
 0.99A 1oniD-5cslA:
undetectable
1oniF-5cslA:
undetectable		 1oniD-5cslA:
5.14
1oniF-5cslA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A1403
ASP A1394
ILE A1353
ILE A1347
 None
 0.85A 1p7lD-5cslA:
undetectable		 1p7lD-5cslA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A1403
ASP A1394
ILE A1353
ILE A1347
 None
 0.84A 1p7lC-5cslA:
undetectable		 1p7lC-5cslA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A1317
ARG A1318
ILE A1385
GLY A1340
ARG A1108
 None
 1.33A 1q8jA-5cslA:
undetectable		 1q8jA-5cslA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A1403
ASP A1394
ILE A1353
ILE A1347
 None
 0.87A 1rg9B-5cslA:
undetectable		 1rg9B-5cslA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A1403
ASP A1394
ILE A1353
ILE A1347
 None
 0.87A 1rg9A-5cslA:
undetectable		 1rg9A-5cslA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A1403
ASP A1394
ILE A1353
ILE A1347
 None
 0.86A 1rg9D-5cslA:
undetectable		 1rg9D-5cslA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A1403
ASP A1394
ILE A1353
ILE A1347
 None
 0.86A 1rg9C-5cslA:
undetectable		 1rg9C-5cslA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1177
VAL A1129
TYR A1105
LEU A1069
LEU A1072
 None
 1.18A 1s19A-5cslA:
undetectable		 1s19A-5cslA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A1884
VAL A1891
GLY A1890
LEU A1860
 None
 0.94A 1s1xA-5cslA:
2.1		 1s1xA-5cslA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A1861
ILE A1820
GLY A1886
GLU A1575
ALA A1882
 None
 1.00A 1sg9B-5cslA:
2.9		 1sg9B-5cslA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A1278
ASN A1249
ARG A1243
VAL A1186
 None
 1.41A 1wu8A-5cslA:
2.5
1wu8C-5cslA:
undetectable		 1wu8A-5cslA:
8.24
1wu8C-5cslA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A1278
ASN A1249
ARG A1243
VAL A1224
 None
 1.32A 1wu8A-5cslA:
2.5
1wu8C-5cslA:
undetectable		 1wu8A-5cslA:
8.24
1wu8C-5cslA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A1860
GLY A1859
LEU A1950
PRO A1835
 None
 0.87A 1ya4A-5cslA:
undetectable		 1ya4A-5cslA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 459
GLY A 507
ILE A 498
LEU A 475
PHE A 536
 None
 0.82A 1z11D-5cslA:
undetectable		 1z11D-5cslA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 543
LEU A 546
VAL A 321
LEU A 562
ARG A 323
 None
 1.22A 2bxfA-5cslA:
undetectable		 2bxfA-5cslA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A1003
PHE A 802
ILE A 830
VAL A 806
PHE A 926
 None
 1.21A 2ft9A-5cslA:
undetectable		 2ft9A-5cslA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 273
ILE A 272
VAL A 265
PHE A 247
ILE A 289
 None
 1.14A 2h42A-5cslA:
undetectable		 2h42A-5cslA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 527
LEU A 547
ILE A 532
LEU A 562
VAL A 321
 None
 1.21A 2hrcB-5cslA:
2.6		 2hrcB-5cslA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 530
LEU A 527
LEU A 547
ILE A 532
LEU A 562
VAL A 321
 None
 1.46A 2pnjA-5cslA:
3.4		 2pnjA-5cslA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 304
ILE A 312
LEU A 314
PHE A 434
HIS A 413
 None
 1.08A 2qo6A-5cslA:
3.0		 2qo6A-5cslA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 532
PHE A 536
GLY A 507
ILE A 509
 None
 0.90A 2qwxA-5cslA:
2.4
2qwxB-5cslA:
undetectable		 2qwxA-5cslA:
7.65
2qwxB-5cslA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A1407
MET A1365
ILE A1368
ALA A1423
LEU A1357
 None
 1.33A 2rctA-5cslA:
0.2		 2rctA-5cslA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 306
HIS A  31
GLY A 177
SER A 182
GLY A 309
 None
 1.24A 2y6rC-5cslA:
undetectable		 2y6rC-5cslA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 LYS A 327
ASN A 381
ARG A 383
GLU A 387
 None
 0.93A 2ys6A-5cslA:
25.2		 2ys6A-5cslA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 TRP A 843
ALA A 911
PRO A 877
ALA A 878
 None
 0.98A 2zgwA-5cslA:
undetectable		 2zgwA-5cslA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A1288
SER A1306
LYS A1328
 None
 1.02A 3aocC-5cslA:
2.3		 3aocC-5cslA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 HIS A 298
THR A 559
LEU A 378
LEU A 367
 None
 1.09A 3bgdA-5cslA:
undetectable		 3bgdA-5cslA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 526
LEU A 527
MET A 523
ILE A  69
 None
 0.86A 3cldB-5cslA:
undetectable		 3cldB-5cslA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A1469
HIS A1384
VAL A1400
LEU A1440
TYR A1487
 None
 1.29A 3dzyD-5cslA:
undetectable		 3dzyD-5cslA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 223
SER A 221
ASP A 225
ASP A 214
 None
 1.21A 3havA-5cslA:
undetectable		 3havA-5cslA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ASN A1319
ASP A1367
ARG A1348
 None
 0.93A 3k13A-5cslA:
undetectable		 3k13A-5cslA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ASN A  67
LEU A 103
ALA A 105
HIS A 499
 None
 0.90A 3kp6A-5cslA:
undetectable		 3kp6A-5cslA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 SER A 502
PHE A 506
SER A 461
ASP A 535
 None
 0.98A 3m0wE-5cslA:
1.6
3m0wF-5cslA:
undetectable
3m0wG-5cslA:
undetectable
3m0wH-5cslA:
undetectable		 3m0wE-5cslA:
4.02
3m0wF-5cslA:
4.02
3m0wG-5cslA:
4.02
3m0wH-5cslA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A1871
GLY A1872
ALA A1874
HIS A1925
SER A1928
 None
 1.20A 3mg02-5cslA:
undetectable
3mg0V-5cslA:
undetectable		 3mg02-5cslA:
6.22
3mg0V-5cslA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 634
LEU A 694
ILE A 582
GLY A 584
ALA A 586
 None
 0.94A 3n8zB-5cslA:
undetectable		 3n8zB-5cslA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A1361
ILE A1385
GLY A1340
ILE A1341
ILE A1425
 None
 1.01A 3ndwB-5cslA:
undetectable		 3ndwB-5cslA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1746
SER A1789
ILE A1754
ASN A1774
GLY A1736
 None
None
None
COA  A2303 ( 4.7A)
None
 1.23A 3nrrA-5cslA:
undetectable		 3nrrA-5cslA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1746
SER A1789
ILE A1754
ASN A1774
GLY A1736
 None
None
None
COA  A2303 ( 4.7A)
None
 1.23A 3nrrB-5cslA:
undetectable		 3nrrB-5cslA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A1361
ILE A1385
GLY A1340
ILE A1341
ILE A1425
 None
 1.10A 3nuoA-5cslA:
undetectable		 3nuoA-5cslA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 475
ILE A 509
SER A 491
VAL A 492
LEU A 478
 None
 0.93A 3ogpA-5cslA:
undetectable		 3ogpA-5cslA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 353
GLY A 357
ALA A 349
THR A 363
LEU A 303
 None
 1.15A 3p2kB-5cslA:
2.5		 3p2kB-5cslA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 128
TYR A 109
GLU A 101
 None
 0.86A 3pfgA-5cslA:
2.1		 3pfgA-5cslA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A1596
PHE A1604
ALA A1712
THR A1715
 None
 1.07A 3t3sC-5cslA:
undetectable		 3t3sC-5cslA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A1596
PHE A1604
ALA A1712
THR A1715
 None
 1.02A 3t3sE-5cslA:
undetectable		 3t3sE-5cslA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 306
HIS A  31
GLY A 177
SER A 182
GLY A 309
 None
 1.25A 3v3oC-5cslA:
2.4		 3v3oC-5cslA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 327
GLU A 387
TRP A 150
 None
 1.14A 3v4tH-5cslA:
undetectable		 3v4tH-5cslA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 SER A1191
LEU A1194
SER A1193
ILE A1245
VAL A1180
 None
 0.95A 3w67A-5cslA:
2.7		 3w67A-5cslA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A1191
LEU A1194
SER A1193
ILE A1245
VAL A1180
 None
 0.93A 3w68A-5cslA:
2.7		 3w68A-5cslA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ARG A1441
LEU A1443
TYR A1487
HIS A1384
 None
 1.03A 3zmdA-5cslA:
undetectable
3zmdB-5cslA:
undetectable		 3zmdA-5cslA:
6.00
3zmdB-5cslA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 912
LEU A 850
LEU A 900
ASP A 859
 None
 0.93A 4aqlA-5cslA:
2.1		 4aqlA-5cslA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A1736
ASN A1587
ILE A1754
LEU A1742
VAL A1740
 None
 1.25A 4azsA-5cslA:
3.1		 4azsA-5cslA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A1736
ASN A1587
ILE A1754
LEU A1742
VAL A1740
 None
 1.18A 4azwA-5cslA:
2.7		 4azwA-5cslA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 472
ASP A 535
GLY A 473
VAL A 492
HIS A 476
 None
 1.34A 4c5nB-5cslA:
3.0		 4c5nB-5cslA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 MET A1564
ASP A1601
GLY A1734
SER A1732
ILE A1735
 None
None
COA  A2303 (-3.5A)
None
None
 1.42A 4djeA-5cslA:
undetectable		 4djeA-5cslA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 507
ILE A 498
LEU A 475
PHE A 536
 None
 0.81A 4ejjD-5cslA:
undetectable		 4ejjD-5cslA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 1.05A 4f3tA-5cslA:
3.0		 4f3tA-5cslA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 546
LEU A 527
GLN A 322
GLU A 331
 None
 1.26A 4i41A-5cslA:
1.7		 4i41A-5cslA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 489
TRP A 150
HIS A 388
GLY A 362
SER A  77
 None
 1.22A 4kn2A-5cslA:
undetectable		 4kn2A-5cslA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_B_LYAB304_1
(FOLATE RECEPTOR BETA)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 489
TRP A 150
HIS A 388
GLY A 362
SER A  77
 None
 1.21A 4kn2B-5cslA:
undetectable		 4kn2B-5cslA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_1
(FOLATE RECEPTOR BETA)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 489
TRP A 150
HIS A 388
GLY A 362
SER A  77
 None
 1.22A 4kn2C-5cslA:
undetectable		 4kn2C-5cslA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 387
ARG A 458
GLU A 300
GLU A 365
 None
 1.41A 4kr3A-5cslA:
undetectable		 4kr3A-5cslA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 405
LEU A 304
THR A 390
MET A 393
 None
 0.96A 4mbsA-5cslA:
undetectable		 4mbsA-5cslA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		7 / 7 LYS A 327
ASN A 381
ARG A 383
GLN A 385
VAL A 386
GLU A 387
ARG A 458
 None
 0.70A 4mv7A-5cslA:
43.7		 4mv7A-5cslA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A1403
ASP A1394
ILE A1353
ILE A1347
 None
 0.88A 4ndnB-5cslA:
undetectable		 4ndnB-5cslA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A1403
ASP A1394
ILE A1353
ILE A1347
 None
 0.89A 4ndnD-5cslA:
undetectable		 4ndnD-5cslA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A1393
ILE A1347
ASN A1079
ARG A1348
 None
 1.09A 4o7gA-5cslA:
3.2
4o7gB-5cslA:
undetectable		 4o7gA-5cslA:
7.67
4o7gB-5cslA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 127
ASP A 102
ASP A 503
 None
 0.77A 4obwD-5cslA:
undetectable		 4obwD-5cslA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1542
THR A1551
TYR A1610
GLU A1546
ASP A1545
 None
 1.46A 4qb9E-5cslA:
undetectable		 4qb9E-5cslA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 ALA A 179
VAL A 220
GLY A 218
THR A 217
 None
 1.04A 4ubeA-5cslA:
3.8		 4ubeA-5cslA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 1.06A 4z4fA-5cslA:
3.4		 4z4fA-5cslA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 876
HIS A 912
LEU A 907
PRO A 877
 None
 1.40A 5csyB-5cslA:
undetectable		 5csyB-5cslA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 VAL A1878
VAL A1891
GLY A1890
PHE A1866
 None
 1.02A 5d4nA-5cslA:
undetectable
5d4nC-5cslA:
undetectable		 5d4nA-5cslA:
4.67
5d4nC-5cslA:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 510
SER A 519
ALA A 511
HIS A 453
 None
 1.28A 5dzkB-5cslA:
10.3
5dzkP-5cslA:
undetectable		 5dzkB-5cslA:
6.60
5dzkP-5cslA:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 510
SER A 519
ALA A 511
HIS A 453
 None
 1.29A 5dzkg-5cslA:
10.3
5dzku-5cslA:
undetectable		 5dzkg-5cslA:
6.60
5dzku-5cslA:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 122
GLY A 121
HIS A 499
ASP A 102
 None
 0.67A 5f8yA-5cslA:
undetectable		 5f8yA-5cslA:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 122
GLY A 121
HIS A 499
ASP A 102
 None
 0.68A 5f8yB-5cslA:
undetectable		 5f8yB-5cslA:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A 848
LEU A 881
MET A 862
 None
 0.85A 5ikrB-5cslA:
undetectable		 5ikrB-5cslA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 1.01A 5ki6A-5cslA:
2.2		 5ki6A-5cslA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1361
ILE A1385
GLY A1340
ILE A1341
ILE A1425
 None
 1.06A 5kqyA-5cslA:
undetectable		 5kqyA-5cslA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A1361
ILE A1385
GLY A1340
ILE A1341
ILE A1425
 None
 1.08A 5kr0A-5cslA:
undetectable		 5kr0A-5cslA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A1925
SER A1928
SER A1871
GLY A1872
ALA A1874
 None
 1.24A 5l5zV-5cslA:
undetectable
5l5zb-5cslA:
undetectable		 5l5zV-5cslA:
8.31
5l5zb-5cslA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A1925
SER A1928
SER A1871
GLY A1872
ALA A1874
 None
 1.24A 5l5zH-5cslA:
undetectable
5l5zN-5cslA:
undetectable		 5l5zH-5cslA:
8.31
5l5zN-5cslA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A1619
ILE A1803
VAL A1584
ASP A1796
ALA A1518
 None
 0.97A 5lg3A-5cslA:
3.2		 5lg3A-5cslA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1619
ILE A1803
VAL A1584
ASP A1796
ALA A1518
 None
 1.00A 5lg3E-5cslA:
undetectable		 5lg3E-5cslA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A2003
ASP A2004
LEU A1950
ALA A1951
ARG A2125
 None
 1.14A 5nd3B-5cslA:
3.3		 5nd3B-5cslA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 465
PRO A 464
GLU A 462
PHE A 468
 None
 1.46A 5oh1C-5cslA:
undetectable		 5oh1C-5cslA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1967
LEU A1978
ASP A1976
ALA A1929
GLY A1998
 None
 1.18A 5syeB-5cslA:
undetectable		 5syeB-5cslA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 0.98A 5t7bA-5cslA:
undetectable		 5t7bA-5cslA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A1403
ASP A1394
ILE A1353
ILE A1347
 None
 0.88A 5t8sA-5cslA:
undetectable		 5t8sA-5cslA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 MET A 862
LEU A 865
ARG A 868
ILE A 885
LEU A 881
 None
 1.10A 5toaB-5cslA:
undetectable		 5toaB-5cslA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A1609
TYR A1610
ARG A1614
 None
 0.67A 5uunA-5cslA:
5.1		 5uunA-5cslA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A1609
TYR A1610
ARG A1614
 None
 0.57A 5uunB-5cslA:
undetectable		 5uunB-5cslA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A1266
ARG A1318
ASP A1084
ASP A1269
 None
 1.06A 5vlmB-5cslA:
1.5		 5vlmB-5cslA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 VAL A1879
GLY A1880
ASP A1938
ALA A1935
LEU A1870
 None
 0.89A 5x6yC-5cslA:
3.8		 5x6yC-5cslA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1361
ILE A1385
GLY A1340
ILE A1341
ILE A1425
 None
 1.05A 6difA-5cslA:
undetectable		 6difA-5cslA:
3.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 678
LEU A 685
HIS A 625
THR A 587
 None
 1.23A 6dyoA-5cslA:
undetectable		 6dyoA-5cslA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 205
GLY A 207
SER A 204
ILE A 187
GLN A 228
 None
 1.12A 6exiC-5cslA:
undetectable
6exiD-5cslA:
undetectable		 6exiC-5cslA:
3.37
6exiD-5cslA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 ARG A1304
GLU A1301
GLU A1424
ARG A1441
 None
 1.25A 6fk2A-5cslA:
undetectable		 6fk2A-5cslA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 ARG A1441
GLU A1424
GLU A1301
ARG A1304
 None
 1.29A 6fk2A-5cslA:
undetectable		 6fk2A-5cslA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP A1510
SER A1448
GLY A1476
SER A1471
 None
 1.01A 6giqL-5cslA:
undetectable
6giqP-5cslA:
undetectable
6giqT-5cslA:
undetectable		 6giqL-5cslA:
12.63
6giqP-5cslA:
7.34
6giqT-5cslA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5csl ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A  85
VAL A  78
ASP A  48
PHE A  49
VAL A  58
 None
 1.47A 6iblA-5cslA:
undetectable		 6iblA-5cslA:
11.26