SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5css'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 5css TRIOSEPHOSPHATE
ISOMERASE
(Thermoplasma
acidophilum) 		5 / 9 LEU A   8
ILE A 142
GLY A 173
ILE A 193
VAL A 200
 None
G3P  A 301 (-4.0A)
None
None
None
 1.13A 2r5qA-5cssA:
undetectable		 2r5qA-5cssA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 5css TRIOSEPHOSPHATE
ISOMERASE
(Thermoplasma
acidophilum) 		5 / 9 LEU A   8
ILE A 142
GLY A 173
ILE A 193
VAL A 200
 None
G3P  A 301 (-4.0A)
None
None
None
 1.13A 2r5qC-5cssA:
undetectable		 2r5qC-5cssA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5css TRIOSEPHOSPHATE
ISOMERASE
(Thermoplasma
acidophilum) 		5 / 12 HIS A  59
ASP A  61
ASN A 101
LEU A  94
LEU A  87
 None
 1.37A 3g1uA-5cssA:
undetectable		 3g1uA-5cssA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5css TRIOSEPHOSPHATE
ISOMERASE
(Thermoplasma
acidophilum) 		3 / 3 ALA A  17
ARG A  21
LYS A  25
 None
 1.08A 3kp5B-5cssA:
undetectable		 3kp5B-5cssA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 5css TRIOSEPHOSPHATE
ISOMERASE
(Thermoplasma
acidophilum) 		4 / 8 SER A  90
ASP A 140
GLU A 122
GLU A 121
 None
 1.11A 3sg9B-5cssA:
undetectable		 3sg9B-5cssA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 5css TRIOSEPHOSPHATE
ISOMERASE
(Thermoplasma
acidophilum) 		4 / 5 GLU A 180
SER A 149
ARG A 183
SER A 147
 None
 1.42A 4k17B-5cssA:
undetectable		 4k17B-5cssA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5css TRIOSEPHOSPHATE
ISOMERASE
(Thermoplasma
acidophilum) 		5 / 12 ARG A  96
ILE A 162
TYR A 163
LEU A 115
ILE A 134
 None
 1.17A 5b8iC-5cssA:
undetectable		 5b8iC-5cssA:
20.44