SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cth'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 5cth BIDIRECTIONAL SUGAR
TRANSPORTER SWEET2B
(Oryza
sativa) 		5 / 12 LEU A  49
LEU A  52
LEU A  85
ILE A  88
ILE A  92
 None
 0.67A 2bdmA-5cthA:
undetectable		 2bdmA-5cthA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 5cth BIDIRECTIONAL SUGAR
TRANSPORTER SWEET2B
(Oryza
sativa) 		5 / 12 PHE A 134
GLY A 114
LEU A 117
PHE A 115
SER A 119
 None
 1.32A 3tbgC-5cthA:
undetectable		 3tbgC-5cthA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5cth BIDIRECTIONAL SUGAR
TRANSPORTER SWEET2B
(Oryza
sativa) 		3 / 3 VAL A 163
TYR A 211
GLN A 207
 None
 0.70A 5qgkA-5cthA:
undetectable		 5qgkA-5cthA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5cth BIDIRECTIONAL SUGAR
TRANSPORTER SWEET2B
(Oryza
sativa) 		3 / 3 VAL A 163
TYR A 211
GLN A 207
 None
 0.72A 5qgrA-5cthA:
undetectable		 5qgrA-5cthA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5cth BIDIRECTIONAL SUGAR
TRANSPORTER SWEET2B
(Oryza
sativa) 		3 / 3 VAL A 163
TYR A 211
GLN A 207
 None
 0.65A 5qgtA-5cthA:
undetectable		 5qgtA-5cthA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 5cth BIDIRECTIONAL SUGAR
TRANSPORTER SWEET2B
(Oryza
sativa) 		5 / 10 LEU A 143
PHE A  83
LEU A  21
ALA A  20
LEU A  23
 None
 1.24A 5y7pB-5cthA:
undetectable		 5y7pB-5cthA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 5cth BIDIRECTIONAL SUGAR
TRANSPORTER SWEET2B
(Oryza
sativa) 		5 / 10 LEU A 143
PHE A  83
LEU A  21
ALA A  20
LEU A  23
 None
 1.24A 5y7pD-5cthA:
undetectable		 5y7pD-5cthA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 5cth BIDIRECTIONAL SUGAR
TRANSPORTER SWEET2B
(Oryza
sativa) 		5 / 10 LEU A 143
PHE A  83
LEU A  21
ALA A  20
LEU A  23
 None
 1.27A 5y7pG-5cthA:
undetectable		 5y7pG-5cthA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 5cth BIDIRECTIONAL SUGAR
TRANSPORTER SWEET2B
(Oryza
sativa) 		5 / 10 LEU A 143
PHE A  83
LEU A  21
ALA A  20
LEU A  23
 None
 1.18A 5y7pH-5cthA:
undetectable		 5y7pH-5cthA:
22.51