SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cu1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 5cu1 DMSP LYASE
(Ruegeria
pomeroyi) 		5 / 12 MET A 119
GLU A 200
THR A 173
LEU A 123
TYR A  82
 None
 1.49A 2mjiA-5cu1A:
undetectable		 2mjiA-5cu1A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 5cu1 DMSP LYASE
(Ruegeria
pomeroyi) 		5 / 12 MET A 119
TYR A 124
THR A 173
LEU A 123
TYR A  82
 None
 1.40A 2mjiA-5cu1A:
undetectable		 2mjiA-5cu1A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 5cu1 DMSP LYASE
(Ruegeria
pomeroyi) 		4 / 6 THR A  59
MET A 179
PHE A  69
ILE A  70
 None
 1.34A 2w98B-5cu1A:
undetectable		 2w98B-5cu1A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 5cu1 DMSP LYASE
(Ruegeria
pomeroyi) 		4 / 6 HIS A 130
HIS A 169
TYR A 136
GLU A 134
 FE  A 301 (-3.6A)
FE  A 301 (-3.4A)
None
FE  A 301 (-2.1A)
 1.09A 4pahA-5cu1A:
undetectable		 4pahA-5cu1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 5cu1 DMSP LYASE
(Ruegeria
pomeroyi) 		5 / 12 ALA A 113
LEU A 188
GLY A 105
PRO A 106
ALA A 108
 None
 1.22A 4ypmA-5cu1A:
undetectable		 4ypmA-5cu1A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 5cu1 DMSP LYASE
(Ruegeria
pomeroyi) 		5 / 12 LEU A  31
LEU A 100
GLY A 102
SER A 109
LEU A  35
 None
 1.35A 4zbrA-5cu1A:
undetectable		 4zbrA-5cu1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5cu1 DMSP LYASE
(Ruegeria
pomeroyi) 		4 / 6 ALA A 170
THR A 171
VAL A 161
HIS A 169
 None
None
None
FE  A 301 (-3.4A)
 0.95A 5eclA-5cu1A:
undetectable		 5eclA-5cu1A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5cu1 DMSP LYASE
(Ruegeria
pomeroyi) 		4 / 4 HIS A 130
HIS A 169
TYR A 136
GLU A 134
 FE  A 301 (-3.6A)
FE  A 301 (-3.4A)
None
FE  A 301 (-2.1A)
 1.09A 5pahA-5cu1A:
undetectable		 5pahA-5cu1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 5cu1 DMSP LYASE
(Ruegeria
pomeroyi) 		5 / 12 LEU A  80
PRO A  46
PHE A  69
VAL A  75
PHE A   8
 None
 1.34A 5x6yA-5cu1A:
undetectable		 5x6yA-5cu1A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5cu1 DMSP LYASE
(Ruegeria
pomeroyi) 		5 / 9 TYR A  98
ALA A  71
ALA A  68
LEU A 139
LEU A  57
 None
 1.41A 6ay6A-5cu1A:
undetectable		 6ay6A-5cu1A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5cu1 DMSP LYASE
(Ruegeria
pomeroyi) 		6 / 12 TYR A  98
ALA A  71
ALA A  68
LEU A 139
ILE A 138
LEU A  57
 None
 1.45A 6aybA-5cu1A:
undetectable		 6aybA-5cu1A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5cu1 DMSP LYASE
(Ruegeria
pomeroyi) 		4 / 6 MET A  51
ALA A 180
LEU A 139
ALA A 140
 None
 1.20A 6fosB-5cu1A:
undetectable		 6fosB-5cu1A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5cu1 DMSP LYASE
(Ruegeria
pomeroyi) 		5 / 6 PRO A 192
HIS A 130
HIS A 169
TYR A 136
GLU A 134
 None
FE  A 301 (-3.6A)
FE  A 301 (-3.4A)
None
FE  A 301 (-2.1A)
 1.11A 6pahA-5cu1A:
undetectable		 6pahA-5cu1A:
21.32