SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cuk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cuk RULER PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 312
ALA A 314
GLN A 348
VAL A 270
LEU A 291
 None
 1.02A 1fm6A-5cukA:
undetectable		 1fm6A-5cukA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 5cuk RULER PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 294
GLY A 317
ALA A 325
LEU A 329
PHE A 346
 None
 1.19A 1gs4A-5cukA:
undetectable		 1gs4A-5cukA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 5cuk RULER PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 333
LEU A 329
LEU A 258
ILE A 310
VAL A 297
 None
 1.25A 2qd3A-5cukA:
undetectable		 2qd3A-5cukA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 5cuk RULER PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 303
HIS A 337
ILE A 274
 GOL  A 402 (-2.8A)
GOL  A 402 (-4.3A)
GOL  A 402 (-4.4A)
 0.82A 3u52A-5cukA:
undetectable
3u52C-5cukA:
undetectable		 3u52A-5cukA:
14.47
3u52C-5cukA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cuk RULER PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 312
ALA A 314
GLN A 348
VAL A 270
LEU A 291
 None
 1.18A 4nqaA-5cukA:
undetectable		 4nqaA-5cukA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5cuk RULER PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 GLN A 340
GLN A 334
LEU A 308
ILE A 310
ARG A 326
 GOL  A 402 (-3.9A)
None
GOL  A 402 ( 4.4A)
None
GOL  A 401 (-3.3A)
 1.49A 5uacC-5cukA:
undetectable		 5uacC-5cukA:
6.48