SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cuo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5cuo PHOSPHATE
PROPANOYLTRANSFERASE
(Rhodopseudomonas
palustris) 		5 / 12 ALA A 154
HIS A  48
GLU A 109
HIS A  50
HIS A 159
 None
COA  A 501 ( 3.0A)
ZN  A 503 (-2.3A)
ZN  A 503 ( 3.3A)
ZN  A 502 (-3.4A)
 1.25A 2c6nA-5cuoA:
undetectable		 2c6nA-5cuoA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 5cuo PHOSPHATE
PROPANOYLTRANSFERASE
(Rhodopseudomonas
palustris) 		4 / 8 HIS A 157
HIS A 159
HIS A 204
ALA A 154
 ZN  A 502 (-3.3A)
ZN  A 502 (-3.4A)
ZN  A 502 ( 3.1A)
None
 0.91A 2it4A-5cuoA:
undetectable		 2it4A-5cuoA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5cuo PHOSPHATE
PROPANOYLTRANSFERASE
(Rhodopseudomonas
palustris) 		4 / 5 LEU A 130
THR A 133
GLU A 105
HIS A  50
 None
None
None
ZN  A 503 ( 3.3A)
 1.44A 3n58C-5cuoA:
undetectable		 3n58C-5cuoA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 5cuo PHOSPHATE
PROPANOYLTRANSFERASE
(Rhodopseudomonas
palustris) 		4 / 6 GLN A 107
HIS A 157
HIS A 159
HIS A 204
 None
ZN  A 502 (-3.3A)
ZN  A 502 (-3.4A)
ZN  A 502 ( 3.1A)
 1.09A 3nvcA-5cuoA:
undetectable		 3nvcA-5cuoA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 5cuo PHOSPHATE
PROPANOYLTRANSFERASE
(Rhodopseudomonas
palustris) 		5 / 9 ASP A  55
ILE A 138
GLY A 150
ILE A 152
ILE A  49
 None
 1.02A 3s45A-5cuoA:
2.4		 3s45A-5cuoA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 5cuo PHOSPHATE
PROPANOYLTRANSFERASE
(Rhodopseudomonas
palustris) 		4 / 6 HIS A 204
HIS A  48
GLU A 109
SER A 127
 ZN  A 502 ( 3.1A)
COA  A 501 ( 3.0A)
ZN  A 503 (-2.3A)
None
 1.41A 4apjA-5cuoA:
undetectable
4apjP-5cuoA:
undetectable		 4apjA-5cuoA:
16.13
4apjP-5cuoA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5cuo PHOSPHATE
PROPANOYLTRANSFERASE
(Rhodopseudomonas
palustris) 		4 / 8 THR A 121
PRO A 122
VAL A 112
SER A 111
 None
 1.15A 4qknA-5cuoA:
undetectable		 4qknA-5cuoA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5cuo PHOSPHATE
PROPANOYLTRANSFERASE
(Rhodopseudomonas
palustris) 		5 / 11 VAL A 110
VAL A 151
VAL A 108
ILE A 139
LEU A 118
 None
 1.12A 5e4dB-5cuoA:
undetectable		 5e4dB-5cuoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5cuo PHOSPHATE
PROPANOYLTRANSFERASE
(Rhodopseudomonas
palustris) 		5 / 10 ARG A 171
LEU A 170
GLY A 169
ILE A 205
LEU A 213
 None
 1.10A 5oy01-5cuoA:
undetectable
5oy07-5cuoA:
undetectable		 5oy01-5cuoA:
18.88
5oy07-5cuoA:
10.55