SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cuv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5cuv ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		5 / 10 ILE A 227
LEU A 273
VAL A 313
GLY A 311
GLN A 309
 None
 1.20A 2wd9C-5cuvA:
undetectable		 2wd9C-5cuvA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5cuv ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		4 / 8 ASP A 323
ASP A 328
TRP A 364
TYR A 270
 None
MG  A 502 (-3.4A)
None
None
 1.25A 3havA-5cuvA:
undetectable		 3havA-5cuvA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 5cuv ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		5 / 12 THR A  42
GLY A  39
GLU A  60
LEU A  50
ALA A  81
 None
 0.77A 3t7vA-5cuvA:
undetectable		 3t7vA-5cuvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5cuv ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		4 / 6 HIS A 202
SER A 199
GLU A 229
ASP A 252
 None
 1.28A 4blvA-5cuvA:
undetectable		 4blvA-5cuvA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5cuv ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		4 / 8 ASN A 247
GLU A 239
ILE A 240
ASP A 293
 None
 0.84A 4d33A-5cuvA:
undetectable		 4d33A-5cuvA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5cuv ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		4 / 7 ASN A 247
GLU A 239
ILE A 240
ASP A 293
 None
 0.92A 4d33B-5cuvA:
undetectable		 4d33B-5cuvA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5cuv ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		4 / 8 ASN A 247
GLU A 239
ILE A 240
ASP A 293
 None
 0.96A 4d39A-5cuvA:
undetectable		 4d39A-5cuvA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5cuv ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		4 / 7 ASN A 247
GLU A 239
ILE A 240
ASP A 293
 None
 0.90A 4d39B-5cuvA:
undetectable		 4d39B-5cuvA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5cuv ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		3 / 3 PRO A 274
VAL A 313
HIS A 336
 None
None
MLT  A 501 (-4.2A)
 0.61A 4pevC-5cuvA:
undetectable		 4pevC-5cuvA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5cuv ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		3 / 3 VAL A 310
ALA A 312
PHE A 305
 None
 0.91A 4z4iA-5cuvA:
undetectable		 4z4iA-5cuvA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5cuv ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		3 / 3 VAL A 310
ALA A 312
PHE A 305
 None
 0.90A 5js1A-5cuvA:
undetectable		 5js1A-5cuvA:
18.76