SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cux'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5cux ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		4 / 8 ASP A 323
ASP A 328
TRP A 364
TYR A 270
 POP  A 802 (-2.8A)
None
None
None
 1.27A 3havA-5cuxA:
undetectable		 3havA-5cuxA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5cux ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		3 / 3 LYS A 237
ARG A 259
ASP A 291
 POP  A 802 (-3.1A)
PO4  A 805 (-3.7A)
None
 1.45A 3o7wA-5cuxA:
undetectable		 3o7wA-5cuxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5cux ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		3 / 3 LYS A 237
ARG A 259
ASP A 328
 POP  A 802 (-3.1A)
PO4  A 805 (-3.7A)
None
 1.35A 3o7wA-5cuxA:
undetectable		 3o7wA-5cuxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 5cux ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		3 / 3 GLU A 299
PHE A 226
GLN A 309
 None
 0.93A 3r55A-5cuxA:
undetectable		 3r55A-5cuxA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5cux ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		4 / 4 LYS A 250
PRO A 258
ILE A 253
ARG A 182
 None
 1.49A 3v4tC-5cuxA:
0.0
3v4tD-5cuxA:
0.0		 3v4tC-5cuxA:
21.20
3v4tD-5cuxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5cux ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		4 / 7 ASN A 247
GLU A 239
ILE A 240
ASP A 293
 None
 1.06A 4d39B-5cuxA:
undetectable		 4d39B-5cuxA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5cux ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		3 / 3 PRO A 274
VAL A 313
HIS A 336
 None
None
POP  A 801 ( 4.8A)
 0.82A 4pevC-5cuxA:
undetectable		 4pevC-5cuxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 5cux ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		3 / 3 ASN A 247
SER A 199
ARG A 406
 None
 0.95A 5b2qA-5cuxA:
undetectable		 5b2qA-5cuxA:
10.61