SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cuy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		3 / 3 TRP A 201
VAL A 295
TRP A 402
 None
 1.26A 1c4dC-5cuyA:
undetectable
1c4dD-5cuyA:
undetectable		 1c4dC-5cuyA:
8.93
1c4dD-5cuyA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		3 / 3 TRP A 402
VAL A 295
TRP A 201
 None
 1.30A 1c4dC-5cuyA:
undetectable
1c4dD-5cuyA:
undetectable		 1c4dC-5cuyA:
8.93
1c4dD-5cuyA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		3 / 3 ASP A 291
GLU A 229
ARG A 259
 MG  A 902 (-3.2A)
None
None
 0.77A 1wopA-5cuyA:
undetectable		 1wopA-5cuyA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		3 / 3 ASP A 328
GLU A 229
ARG A 259
 MG  A 902 (-4.3A)
None
None
 0.78A 1wopA-5cuyA:
undetectable		 1wopA-5cuyA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		3 / 3 VAL A 295
TRP A 402
TRP A 201
 None
 1.14A 2xdcC-5cuyA:
undetectable
2xdcD-5cuyA:
undetectable		 2xdcC-5cuyA:
8.93
2xdcD-5cuyA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		3 / 3 LYS A 237
ARG A 259
ASP A 323
 None
 0.94A 3o7wA-5cuyA:
undetectable		 3o7wA-5cuyA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		3 / 3 LYS A 237
ARG A 259
ASP A 328
 None
None
MG  A 902 (-4.3A)
 1.25A 3o7wA-5cuyA:
undetectable		 3o7wA-5cuyA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		3 / 3 GLU A 299
PHE A 226
GLN A 309
 None
 0.95A 3r55A-5cuyA:
undetectable		 3r55A-5cuyA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		3 / 3 ASN A  36
ALA A  48
ARG A  83
 None
 0.82A 3tj7C-5cuyA:
undetectable
3tj7D-5cuyA:
undetectable		 3tj7C-5cuyA:
18.60
3tj7D-5cuyA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		3 / 3 VAL A 295
TRP A 402
TRP A 201
 None
 1.12A 3zq8A-5cuyA:
undetectable
3zq8B-5cuyA:
undetectable		 3zq8A-5cuyA:
8.93
3zq8B-5cuyA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		4 / 7 ASN A 247
GLU A 239
ILE A 240
ASP A 293
 None
 1.10A 4d33B-5cuyA:
undetectable		 4d33B-5cuyA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		4 / 7 ASN A 247
GLU A 239
ILE A 240
ASP A 293
 None
 1.04A 4d39B-5cuyA:
undetectable		 4d39B-5cuyA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		4 / 7 HIS A 348
ASP A 346
PRO A 351
VAL A 332
 None
 0.94A 4hvrA-5cuyA:
undetectable		 4hvrA-5cuyA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		3 / 3 ARG A 106
GLU A 103
PHE A  88
 None
 0.89A 4kszA-5cuyA:
undetectable		 4kszA-5cuyA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		3 / 3 PRO A 274
VAL A 313
HIS A 336
 None
None
CIT  A 901 (-3.8A)
 0.66A 4pevC-5cuyA:
undetectable		 4pevC-5cuyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		4 / 5 PHE A 273
PRO A 294
VAL A 295
ALA A 272
 None
 1.10A 4z4cA-5cuyA:
undetectable		 4z4cA-5cuyA:
18.44