SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cvi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 5cvi SLOR
(Streptococcus
mutans) 		4 / 5 ILE A  12
LEU A  15
SER A  16
ARG A  18
 None
 0.86A 2byoA-5cviA:
undetectable		 2byoA-5cviA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 5cvi SLOR
(Streptococcus
mutans) 		5 / 9 LEU A 101
HIS A  76
GLU A 102
HIS A  95
LEU A  83
 None
ZN  A 303 (-3.2A)
ZN  A 301 (-3.0A)
ZN  A 303 (-3.1A)
None
 1.08A 2jihA-5cviA:
undetectable		 2jihA-5cviA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 5cvi SLOR
(Streptococcus
mutans) 		5 / 8 LEU A 101
HIS A  76
GLU A 102
HIS A  95
LEU A  83
 None
ZN  A 303 (-3.2A)
ZN  A 301 (-3.0A)
ZN  A 303 (-3.1A)
None
 1.31A 2jihB-5cviA:
undetectable		 2jihB-5cviA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 5cvi SLOR
(Streptococcus
mutans) 		3 / 3 GLU A 111
SER A 106
VAL A 105
 ZN  A 304 (-3.2A)
None
None
 0.82A 3eeoA-5cviA:
undetectable		 3eeoA-5cviA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5cvi SLOR
(Streptococcus
mutans) 		5 / 9 LEU A 101
HIS A  76
GLU A 102
HIS A  95
ILE A  94
 None
ZN  A 303 (-3.2A)
ZN  A 301 (-3.0A)
ZN  A 303 (-3.1A)
None
 1.30A 3hy7A-5cviA:
undetectable		 3hy7A-5cviA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5cvi SLOR
(Streptococcus
mutans) 		5 / 9 LEU A 101
HIS A  76
GLU A 102
HIS A  95
LEU A  83
 None
ZN  A 303 (-3.2A)
ZN  A 301 (-3.0A)
ZN  A 303 (-3.1A)
None
 1.29A 3hy7A-5cviA:
undetectable		 3hy7A-5cviA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EBK_B_TOYB302_1
(AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE)		 5cvi SLOR
(Streptococcus
mutans) 		5 / 9 ASP A   7
TYR A  73
ALA A  69
GLU A 102
GLU A  99
 ZN  A 301 (-2.5A)
None
None
ZN  A 301 (-3.0A)
ZN  A 301 (-2.2A)
 1.49A 4ebkA-5cviA:
0.0
4ebkB-5cviA:
0.0		 4ebkA-5cviA:
20.64
4ebkB-5cviA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5cvi SLOR
(Streptococcus
mutans) 		3 / 3 ARG A  74
LEU A  78
PHE A  82
 ZN  A 304 ( 4.3A)
None
None
 0.43A 6nknP-5cviA:
undetectable		 6nknP-5cviA:
19.78