SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cvo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 12 GLY A 518
GLU A 519
VAL A 546
VAL A  15
ARG A 114
 None
 1.17A 1n2xA-5cvoA:
undetectable		 1n2xA-5cvoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		3 / 3 ARG A 287
TYR A 277
LYS A 275
 None
 1.04A 1uujB-5cvoA:
undetectable		 1uujB-5cvoA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 11 ARG A  30
GLY A 359
GLY A  49
THR A 317
THR A 316
 None
 1.49A 1v54G-5cvoA:
undetectable
1v54N-5cvoA:
undetectable
1v54O-5cvoA:
undetectable		 1v54G-5cvoA:
10.14
1v54N-5cvoA:
22.56
1v54O-5cvoA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46
(Homo
sapiens) 		3 / 3 PHE B  59
VAL B 168
TRP B 167
 None
 0.88A 2cc8A-5cvoB:
undetectable		 2cc8A-5cvoB:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46
(Homo
sapiens) 		3 / 3 PHE B  59
VAL B 168
TRP B 167
 None
 0.88A 2ccbA-5cvoB:
undetectable		 2ccbA-5cvoB:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 5 LEU A 164
GLY A 166
ILE A 171
ILE A 141
 None
 0.84A 2q9rA-5cvoA:
undetectable		 2q9rA-5cvoA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46
(Homo
sapiens;
Homo
sapiens) 		3 / 3 GLN B 239
THR B 187
TRP A 256
 None
 1.15A 2rctA-5cvoB:
undetectable		 2rctA-5cvoB:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 11 ALA A 104
VAL A 101
CYH A  85
GLY A  87
VAL A 132
 None
 1.20A 2uxpB-5cvoA:
undetectable		 2uxpB-5cvoA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46
(Homo
sapiens) 		3 / 3 PHE B  59
VAL B 168
TRP B 167
 None
 0.87A 2vx9A-5cvoB:
undetectable		 2vx9A-5cvoB:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB8_A_IMNA800_1
(PROSTAGLANDIN
REDUCTASE 2)		 5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46
(Homo
sapiens) 		5 / 9 THR B  78
PHE B 172
LEU B  50
VAL B  49
LEU B  53
 None
 1.35A 2zb8A-5cvoB:
undetectable		 2zb8A-5cvoB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_G_CHDG229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 10 ARG A  30
GLY A 359
GLY A  49
THR A 317
THR A 316
 None
 1.50A 3asnG-5cvoA:
undetectable
3asnN-5cvoA:
undetectable
3asnO-5cvoA:
undetectable		 3asnG-5cvoA:
10.14
3asnN-5cvoA:
22.56
3asnO-5cvoA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_G_CHDG229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 10 ARG A  30
GLY A 359
GLY A  49
THR A 317
THR A 316
 None
 1.50A 3asoG-5cvoA:
undetectable
3asoN-5cvoA:
undetectable
3asoO-5cvoA:
undetectable		 3asoG-5cvoA:
10.14
3asoN-5cvoA:
22.56
3asoO-5cvoA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 7 PHE A 264
GLN A 224
LEU A 226
LEU A 236
 None
 0.76A 3bgdB-5cvoA:
undetectable		 3bgdB-5cvoA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46
(Homo
sapiens) 		4 / 6 VAL B 303
LEU B 128
ILE B 340
ILE B 315
 None
 0.92A 3gcsA-5cvoB:
undetectable		 3gcsA-5cvoB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46
(Homo
sapiens) 		3 / 3 GLU B 170
GLU B  61
ASN B  62
 None
 0.86A 3lp9B-5cvoB:
undetectable
3lp9D-5cvoB:
undetectable		 3lp9B-5cvoB:
20.39
3lp9D-5cvoB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 12 GLY A 136
SER A 173
ASP A  80
ALA A  93
ASP A 118
 None
 1.30A 3nmuA-5cvoA:
undetectable
3nmuF-5cvoA:
undetectable		 3nmuA-5cvoA:
20.45
3nmuF-5cvoA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 10 LEU A 226
ALA A 215
GLY A 254
VAL A 267
LEU A 258
 None
 1.03A 3ogpA-5cvoA:
undetectable		 3ogpA-5cvoA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46
WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 8 ARG B 181
LEU A 137
ASP A 169
TYR A 172
 None
 0.96A 3qj7A-5cvoB:
undetectable
3qj7D-5cvoB:
undetectable		 3qj7A-5cvoB:
19.78
3qj7D-5cvoB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 4 GLY A  32
GLY A  49
THR A  47
LEU A  36
 None
 0.90A 3si7C-5cvoA:
undetectable
3si7D-5cvoA:
undetectable		 3si7C-5cvoA:
19.24
3si7D-5cvoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46
(Homo
sapiens) 		4 / 7 PHE B  84
PHE B  55
ALA B  52
THR B 316
 None
 1.08A 4ejgA-5cvoB:
undetectable		 4ejgA-5cvoB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 7 TYR A 172
ALA A 215
GLY A 228
SER A 230
GLY A 254
 None
 1.26A 5e26A-5cvoA:
undetectable
5e26B-5cvoA:
undetectable		 5e26A-5cvoA:
21.17
5e26B-5cvoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46
(Homo
sapiens) 		5 / 11 ILE B 250
GLN B 173
LEU B 196
VAL B 299
LEU B  53
 None
 1.03A 5ji0A-5cvoB:
undetectable		 5ji0A-5cvoB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 12 GLY A 186
THR A 188
ALA A 135
GLY A 136
ILE A 141
 None
 0.91A 5kb6A-5cvoA:
undetectable		 5kb6A-5cvoA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46
(Homo
sapiens) 		5 / 12 CYH B  46
TYR B 314
ASN B  47
PHE B  84
LEU B  83
 None
 1.46A 5kklB-5cvoB:
undetectable		 5kklB-5cvoB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 12 ALA A 361
GLY A 359
ASP A 379
ILE A 363
GLY A 399
 None
 1.26A 5wwsB-5cvoA:
undetectable		 5wwsB-5cvoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 10 GLY A  49
THR A 317
THR A 316
ARG A  30
GLY A 359
 None
 1.49A 5x1fA-5cvoA:
undetectable
5x1fB-5cvoA:
undetectable
5x1fT-5cvoA:
undetectable		 5x1fA-5cvoA:
22.56
5x1fB-5cvoA:
16.61
5x1fT-5cvoA:
10.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46
(Homo
sapiens) 		6 / 8 GLY B  36
LEU B  37
ASN B  47
SER B  48
GLN B  51
PHE B 327
 None
 0.64A 5xu8A-5cvoB:
33.8		 5xu8A-5cvoB:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 8 GLU A  72
ARG A 531
THR A 513
PRO A 514
 None
 1.05A 6a4iA-5cvoA:
undetectable		 6a4iA-5cvoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 7 GLU A  72
ARG A 531
THR A 513
PRO A 514
 None
 1.36A 6a4iB-5cvoA:
undetectable		 6a4iB-5cvoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 7 ASN A  34
ALA A  48
GLU A 301
LYS A 299
LEU A 298
 None
 1.21A 6ci6A-5cvoA:
undetectable		 6ci6A-5cvoA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46
(Homo
sapiens) 		3 / 3 HIS B 122
ASN B 126
LEU B 129
 None
 0.79A 6f7lB-5cvoB:
undetectable		 6f7lB-5cvoB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46
(Homo
sapiens) 		4 / 5 ASN B  39
GLY B 306
HIS B 313
ASP B 328
 None
 0.42A 6gh9A-5cvoB:
29.4		 6gh9A-5cvoB:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5cvo WD REPEAT-CONTAINING
PROTEIN 48
UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46
(Homo
sapiens;
Homo
sapiens) 		4 / 8 ASP A  76
HIS A 116
ASP A 118
GLU B 237
 None
 1.15A 6mn4A-5cvoA:
undetectable		 6mn4A-5cvoA:
18.46