SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cvv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		6 / 10 GLY A 211
ASP A 234
LEU A 235
VAL A 238
ASP A 254
TRP A 274
 SAH  A 401 (-3.8A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.3A)
None
SAH  A 401 (-3.5A)
None
 0.28A 1fpqA-5cvvA:
24.3		 1fpqA-5cvvA:
46.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		5 / 12 LEU A 111
VAL A  54
SER A  53
VAL A  93
LEU A  84
 None
 1.24A 1ie9A-5cvvA:
undetectable		 1ie9A-5cvvA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNN_H_ESTH350_1
(MONOCLONAL
ANTI-ESTRADIOL
17E12E5
IMMUNOGLOBULIN
GAMMA-1 CHAIN
MONOCLONAL
ANTI-ESTRADIOL
17E12E5
IMMUNOGLOBULIN KAPPA
CHAIN)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		5 / 10 LYS A 137
ASP A 136
TYR A 326
LEU A 139
TYR A 145
 None
None
None
N7I  A 402 (-2.9A)
None
 1.28A 1jnnH-5cvvA:
0.0
1jnnL-5cvvA:
0.0		 1jnnH-5cvvA:
19.45
1jnnL-5cvvA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		7 / 12 TRP A 166
GLY A 211
GLY A 212
GLY A 213
LEU A 235
ASP A 254
TRP A 274
 SAH  A 401 ( 3.6A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 4.2A)
SAH  A 401 ( 3.7A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.5A)
None
 0.79A 1qzzA-5cvvA:
25.0		 1qzzA-5cvvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		7 / 12 TRP A 166
GLY A 211
GLY A 212
GLY A 213
LEU A 235
ASP A 254
TRP A 274
 SAH  A 401 ( 3.6A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 4.2A)
SAH  A 401 ( 3.7A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.5A)
None
 0.56A 1xdsA-5cvvA:
27.7		 1xdsA-5cvvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		5 / 12 TRP A 166
GLY A 212
LEU A 235
ASP A 254
TRP A 274
 SAH  A 401 ( 3.6A)
SAH  A 401 ( 4.2A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.5A)
None
 0.80A 1xdsA-5cvvA:
27.7		 1xdsA-5cvvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		7 / 12 TRP A 166
GLY A 211
GLY A 212
GLY A 213
LEU A 235
ASP A 254
TRP A 274
 SAH  A 401 ( 3.6A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 4.2A)
SAH  A 401 ( 3.7A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.5A)
None
 0.51A 1xdsB-5cvvA:
26.8		 1xdsB-5cvvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		4 / 7 ASP A 136
THR A 171
GLY A 170
TYR A 168
 None
 1.06A 2f6dA-5cvvA:
undetectable		 2f6dA-5cvvA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		5 / 12 PHE A 266
ASP A 209
VAL A 210
ALA A 288
CYH A 286
 None
SAH  A 401 ( 4.6A)
None
None
None
 1.33A 2g70A-5cvvA:
12.3		 2g70A-5cvvA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		5 / 12 PHE A 266
ASP A 209
VAL A 210
ALA A 288
CYH A 286
 None
SAH  A 401 ( 4.6A)
None
None
None
 1.34A 2g70B-5cvvA:
12.5		 2g70B-5cvvA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		5 / 12 PHE A 266
ASP A 209
VAL A 210
ALA A 288
CYH A 286
 None
SAH  A 401 ( 4.6A)
None
None
None
 1.37A 2g72A-5cvvA:
12.5		 2g72A-5cvvA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		5 / 12 SER A 187
GLY A 211
GLY A 215
ALA A 216
LEU A 235
 SAH  A 401 (-2.5A)
SAH  A 401 (-3.8A)
None
None
SAH  A 401 (-4.3A)
 0.78A 2nyuA-5cvvA:
11.0		 2nyuA-5cvvA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		4 / 5 ALA A 216
ASP A 234
ASP A 254
ASP A 209
 None
SAH  A 401 (-2.8A)
SAH  A 401 (-3.5A)
SAH  A 401 ( 4.6A)
 1.19A 2nyuB-5cvvA:
11.0		 2nyuB-5cvvA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		4 / 7 ILE A 297
PHE A 201
MET A 191
THR A 190
 None
 0.96A 2zxwN-5cvvA:
undetectable
2zxwW-5cvvA:
undetectable		 2zxwN-5cvvA:
21.65
2zxwW-5cvvA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		4 / 7 ILE A 297
PHE A 201
MET A 191
THR A 190
 None
 0.99A 3ag2N-5cvvA:
undetectable
3ag2W-5cvvA:
undetectable		 3ag2N-5cvvA:
21.65
3ag2W-5cvvA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		4 / 7 ILE A 297
PHE A 201
MET A 191
THR A 190
 None
 0.99A 3ag4N-5cvvA:
0.7
3ag4W-5cvvA:
undetectable		 3ag4N-5cvvA:
21.65
3ag4W-5cvvA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		4 / 6 ASP A 254
LEU A 282
ASP A 234
TRP A 274
 SAH  A 401 (-3.5A)
None
SAH  A 401 (-2.8A)
None
 0.99A 3bj8C-5cvvA:
undetectable
3bj8D-5cvvA:
undetectable		 3bj8C-5cvvA:
20.70
3bj8D-5cvvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		5 / 12 SER A 187
GLY A 211
GLY A 213
LEU A 235
ASP A 254
 SAH  A 401 (-2.5A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.7A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.5A)
 1.03A 3gczA-5cvvA:
8.1		 3gczA-5cvvA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		6 / 12 TRP A 166
MET A 183
GLY A 212
LEU A 235
ASP A 273
TRP A 274
 SAH  A 401 ( 3.6A)
SAH  A 401 ( 3.9A)
SAH  A 401 ( 4.2A)
SAH  A 401 (-4.3A)
N7I  A 402 ( 2.7A)
None
 0.94A 3i5uA-5cvvA:
28.6		 3i5uA-5cvvA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		8 / 12 TRP A 166
PHE A 179
MET A 183
GLY A 212
GLY A 213
LEU A 235
ASP A 273
TRP A 274
 SAH  A 401 ( 3.6A)
None
SAH  A 401 ( 3.9A)
SAH  A 401 ( 4.2A)
SAH  A 401 ( 3.7A)
SAH  A 401 (-4.3A)
N7I  A 402 ( 2.7A)
None
 0.45A 3i5uA-5cvvA:
28.6		 3i5uA-5cvvA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		7 / 12 TRP A 166
MET A 183
GLY A 212
GLY A 213
LEU A 235
ASP A 273
TRP A 274
 SAH  A 401 ( 3.6A)
SAH  A 401 ( 3.9A)
SAH  A 401 ( 4.2A)
SAH  A 401 ( 3.7A)
SAH  A 401 (-4.3A)
N7I  A 402 ( 2.7A)
None
 0.46A 3i5uB-5cvvA:
26.5		 3i5uB-5cvvA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		6 / 12 TRP A 166
MET A 183
GLY A 212
LEU A 235
ASP A 273
TRP A 274
 SAH  A 401 ( 3.6A)
SAH  A 401 ( 3.9A)
SAH  A 401 ( 4.2A)
SAH  A 401 (-4.3A)
N7I  A 402 ( 2.7A)
None
 0.94A 3i5uB-5cvvA:
26.5		 3i5uB-5cvvA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		4 / 6 LEU A 108
GLU A 106
PRO A  62
ARG A  98
 None
 1.49A 3ltwA-5cvvA:
undetectable		 3ltwA-5cvvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		3 / 3 GLY A 213
ASP A 234
ASP A 254
 SAH  A 401 ( 3.7A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.5A)
 0.38A 3ou7C-5cvvA:
14.6		 3ou7C-5cvvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		5 / 12 GLY A 211
GLY A 213
VAL A 238
ASP A 273
TRP A 274
 SAH  A 401 (-3.8A)
SAH  A 401 ( 3.7A)
None
N7I  A 402 ( 2.7A)
None
 0.39A 4a6eA-5cvvA:
35.2		 4a6eA-5cvvA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		5 / 12 GLY A 213
GLY A 212
GLY A 211
HIS A 250
VAL A 238
 SAH  A 401 ( 3.7A)
SAH  A 401 ( 4.2A)
SAH  A 401 (-3.8A)
None
None
 0.82A 4htfA-5cvvA:
13.6		 4htfA-5cvvA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		5 / 12 GLY A 213
GLY A 212
GLY A 211
HIS A 250
VAL A 238
 SAH  A 401 ( 3.7A)
SAH  A 401 ( 4.2A)
SAH  A 401 (-3.8A)
None
None
 0.78A 4htfB-5cvvA:
13.2		 4htfB-5cvvA:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		10 / 11 SER A 187
GLY A 211
GLY A 212
ASP A 234
LEU A 235
VAL A 238
ASP A 254
MET A 255
LYS A 268
ILE A 270
 SAH  A 401 (-2.5A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 4.2A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.3A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.0A)
SAH  A 401 ( 4.9A)
 0.73A 4pghA-5cvvA:
39.8		 4pghA-5cvvA:
54.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		7 / 11 SER A 187
GLY A 213
ASP A 234
LEU A 235
ASP A 254
MET A 255
ILE A 270
 SAH  A 401 (-2.5A)
SAH  A 401 ( 3.7A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.5A)
SAH  A 401 (-3.6A)
SAH  A 401 ( 4.9A)
 1.19A 4pghA-5cvvA:
39.8		 4pghA-5cvvA:
54.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		11 / 12 SER A 187
ASP A 209
GLY A 211
ASP A 234
LEU A 235
ASP A 254
MET A 255
LYS A 268
ILE A 270
ASP A 273
TRP A 274
 SAH  A 401 (-2.5A)
SAH  A 401 ( 4.6A)
SAH  A 401 (-3.8A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.5A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.0A)
SAH  A 401 ( 4.9A)
N7I  A 402 ( 2.7A)
None
 0.73A 4pghB-5cvvA:
40.1		 4pghB-5cvvA:
54.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		6 / 11 GLY A 212
ASP A 234
LEU A 235
VAL A 238
LYS A 268
TRP A 269
 SAH  A 401 ( 4.2A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.3A)
None
SAH  A 401 (-3.0A)
N7I  A 402 (-4.3A)
 1.37A 4pghC-5cvvA:
39.4		 4pghC-5cvvA:
54.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		11 / 11 SER A 187
GLY A 211
ASP A 234
LEU A 235
VAL A 238
ASP A 254
MET A 255
LYS A 268
TRP A 269
ILE A 270
TRP A 274
 SAH  A 401 (-2.5A)
SAH  A 401 (-3.8A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.3A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.0A)
N7I  A 402 (-4.3A)
SAH  A 401 ( 4.9A)
None
 0.98A 4pghC-5cvvA:
39.4		 4pghC-5cvvA:
54.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		7 / 12 GLY A 211
GLY A 212
ASP A 234
LEU A 235
ASP A 254
PHE A 256
LYS A 268
 SAH  A 401 (-3.8A)
SAH  A 401 ( 4.2A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.5A)
SAH  A 401 (-4.5A)
SAH  A 401 (-3.0A)
 1.07A 4pghD-5cvvA:
39.4		 4pghD-5cvvA:
54.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		9 / 12 SER A 187
GLY A 211
GLY A 212
ASP A 234
LEU A 235
PHE A 256
LYS A 268
ILE A 270
TRP A 274
 SAH  A 401 (-2.5A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 4.2A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.3A)
SAH  A 401 (-4.5A)
SAH  A 401 (-3.0A)
SAH  A 401 ( 4.9A)
None
 0.93A 4pghD-5cvvA:
39.4		 4pghD-5cvvA:
54.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		9 / 12 SER A 187
GLY A 211
GLY A 212
ASP A 234
MET A 255
PHE A 256
LYS A 268
ILE A 270
TRP A 274
 SAH  A 401 (-2.5A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 4.2A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.5A)
SAH  A 401 (-3.0A)
SAH  A 401 ( 4.9A)
None
 1.02A 4pghD-5cvvA:
39.4		 4pghD-5cvvA:
54.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		7 / 12 SER A 187
GLY A 213
ASP A 234
LEU A 235
PHE A 256
ILE A 270
TRP A 274
 SAH  A 401 (-2.5A)
SAH  A 401 ( 3.7A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.3A)
SAH  A 401 (-4.5A)
SAH  A 401 ( 4.9A)
None
 1.30A 4pghD-5cvvA:
39.4		 4pghD-5cvvA:
54.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		7 / 12 SER A 187
GLY A 213
ASP A 234
MET A 255
PHE A 256
ILE A 270
TRP A 274
 SAH  A 401 (-2.5A)
SAH  A 401 ( 3.7A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.5A)
SAH  A 401 ( 4.9A)
None
 1.33A 4pghD-5cvvA:
39.4		 4pghD-5cvvA:
54.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		4 / 7 GLY A 215
SER A 219
PHE A 245
HIS A 250
 None
 1.17A 4ws0A-5cvvA:
undetectable		 4ws0A-5cvvA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		4 / 6 ILE A 155
HIS A 237
ILE A 175
VAL A 138
 None
 0.97A 4zj8A-5cvvA:
undetectable		 4zj8A-5cvvA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		5 / 12 GLY A 212
LEU A 235
VAL A 238
ASP A 273
TRP A 274
 SAH  A 401 ( 4.2A)
SAH  A 401 (-4.3A)
None
N7I  A 402 ( 2.7A)
None
 0.39A 5w7pA-5cvvA:
28.3		 5w7pA-5cvvA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		5 / 12 TRP A 166
GLY A 211
GLY A 213
ASP A 273
TRP A 274
 SAH  A 401 ( 3.6A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.7A)
N7I  A 402 ( 2.7A)
None
 0.76A 6clxA-5cvvA:
24.0		 6clxA-5cvvA:
28.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		10 / 11 GLY A 211
GLY A 213
ASP A 234
LEU A 235
VAL A 238
ASP A 254
MET A 255
LYS A 268
TRP A 269
ASP A 273
 SAH  A 401 (-3.8A)
SAH  A 401 ( 3.7A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.3A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.0A)
N7I  A 402 (-4.3A)
N7I  A 402 ( 2.7A)
 0.77A 6i5zD-5cvvA:
36.8		 6i5zD-5cvvA:
40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		7 / 11 GLY A 212
ASP A 234
LEU A 235
ASP A 254
MET A 255
TRP A 269
ASP A 273
 SAH  A 401 ( 4.2A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.5A)
SAH  A 401 (-3.6A)
N7I  A 402 (-4.3A)
N7I  A 402 ( 2.7A)
 1.20A 6i5zD-5cvvA:
36.8		 6i5zD-5cvvA:
40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		6 / 11 GLY A 212
ASP A 234
LEU A 235
VAL A 238
LYS A 268
TRP A 269
 SAH  A 401 ( 4.2A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.3A)
None
SAH  A 401 (-3.0A)
N7I  A 402 (-4.3A)
 1.48A 6i5zD-5cvvA:
36.8		 6i5zD-5cvvA:
40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		7 / 11 SER A 187
GLY A 213
LEU A 235
VAL A 238
MET A 255
LYS A 268
ASP A 273
 SAH  A 401 (-2.5A)
SAH  A 401 ( 3.7A)
SAH  A 401 (-4.3A)
None
SAH  A 401 (-3.6A)
SAH  A 401 (-3.0A)
N7I  A 402 ( 2.7A)
 0.91A 6i5zD-5cvvA:
36.8		 6i5zD-5cvvA:
40.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE
(Clarkia
breweri) 		6 / 12 ASP A 209
GLY A 211
GLY A 213
VAL A 217
ASP A 254
PHE A 266
 SAH  A 401 ( 4.6A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.7A)
None
SAH  A 401 (-3.5A)
None
 0.87A 6nj9K-5cvvA:
8.5		 6nj9K-5cvvA:
21.28