SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cvw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 5cvw BIFUNCTIONAL
HEMOLYSIN/ADENYLATE
CYCLASE
(Bordetella
pertussis) 		6 / 9 LEU A1634
GLY A1616
ALA A1615
VAL A1594
ILE A1656
ILE A1633
 GOL  A1711 ( 4.3A)
None
None
None
None
None
 1.49A 3nujB-5cvwA:
undetectable		 3nujB-5cvwA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 5cvw BIFUNCTIONAL
HEMOLYSIN/ADENYLATE
CYCLASE
(Bordetella
pertussis) 		6 / 9 LEU A1634
GLY A1616
ALA A1615
VAL A1594
ILE A1656
ILE A1633
 GOL  A1711 ( 4.3A)
None
None
None
None
None
 1.49A 3nuoB-5cvwA:
undetectable		 3nuoB-5cvwA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 5cvw BIFUNCTIONAL
HEMOLYSIN/ADENYLATE
CYCLASE
(Bordetella
pertussis) 		4 / 4 ASP A1560
ASP A1579
GLY A1597
THR A1641
 None
CA  A1702 ( 2.4A)
CA  A1703 ( 4.5A)
None
 1.26A 3tl9B-5cvwA:
undetectable		 3tl9B-5cvwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 5cvw BIFUNCTIONAL
HEMOLYSIN/ADENYLATE
CYCLASE
(Bordetella
pertussis) 		3 / 3 ASP A1570
GLU A1567
GLY A1550
 CA  A1705 ( 2.5A)
MG  A1714 ( 2.5A)
CA  A1704 (-4.2A)
 0.65A 3w9tA-5cvwA:
undetectable		 3w9tA-5cvwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 5cvw BIFUNCTIONAL
HEMOLYSIN/ADENYLATE
CYCLASE
(Bordetella
pertussis) 		4 / 5 ASP A1570
SER A1569
GLY A1586
ASP A1566
 CA  A1705 ( 2.5A)
None
CA  A1706 (-4.3A)
None
 1.48A 3w9tB-5cvwA:
undetectable		 3w9tB-5cvwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 5cvw BIFUNCTIONAL
HEMOLYSIN/ADENYLATE
CYCLASE
(Bordetella
pertussis) 		4 / 5 ASP A1570
SER A1569
GLY A1586
ASP A1566
 CA  A1705 ( 2.5A)
None
CA  A1706 (-4.3A)
None
 1.48A 3w9tC-5cvwA:
undetectable		 3w9tC-5cvwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 5cvw BIFUNCTIONAL
HEMOLYSIN/ADENYLATE
CYCLASE
(Bordetella
pertussis) 		4 / 5 ASP A1570
SER A1569
GLY A1586
ASP A1566
 CA  A1705 ( 2.5A)
None
CA  A1706 (-4.3A)
None
 1.48A 3w9tD-5cvwA:
undetectable		 3w9tD-5cvwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 5cvw BIFUNCTIONAL
HEMOLYSIN/ADENYLATE
CYCLASE
(Bordetella
pertussis) 		5 / 10 LEU A1634
GLY A1616
ALA A1615
ILE A1656
ILE A1633
 GOL  A1711 ( 4.3A)
None
None
None
None
 0.88A 4dqfB-5cvwA:
undetectable		 4dqfB-5cvwA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_B_Z80B401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5cvw BIFUNCTIONAL
HEMOLYSIN/ADENYLATE
CYCLASE
(Bordetella
pertussis) 		5 / 9 ILE A1631
PHE A1592
VAL A1653
ASP A1628
ILE A1601
 None
 1.34A 5lg3B-5cvwA:
undetectable		 5lg3B-5cvwA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_C_Z80C401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5cvw BIFUNCTIONAL
HEMOLYSIN/ADENYLATE
CYCLASE
(Bordetella
pertussis) 		5 / 9 ILE A1631
PHE A1592
VAL A1653
ASP A1628
ILE A1601
 None
 1.35A 5lg3C-5cvwA:
undetectable		 5lg3C-5cvwA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5cvw BIFUNCTIONAL
HEMOLYSIN/ADENYLATE
CYCLASE
(Bordetella
pertussis) 		5 / 9 ILE A1631
PHE A1592
VAL A1653
ASP A1628
ILE A1601
 None
 1.33A 5lg3D-5cvwA:
undetectable		 5lg3D-5cvwA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 5cvw BIFUNCTIONAL
HEMOLYSIN/ADENYLATE
CYCLASE
(Bordetella
pertussis) 		4 / 4 VAL A1544
LEU A1545
LEU A1536
ASP A1552
 None
EDO  A1709 (-4.2A)
EDO  A1709 (-4.3A)
CA  A1704 ( 2.4A)
 1.16A 5xv7A-5cvwA:
undetectable		 5xv7A-5cvwA:
20.13