SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cw2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 PRO C 276
HIS C 102
PHE C 262
ASP C 103
LEU C 271
 None
None
None
BSU  C 401 (-2.8A)
None
 1.48A 1c3sA-5cw2C:
undetectable		 1c3sA-5cw2C:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 TYR C 222
MET C 175
PHE C 231
THR C 229
 None
 1.07A 1ea1A-5cw2C:
undetectable		 1ea1A-5cw2C:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 LEU C 167
ILE C 201
HIS C 297
ASP C 103
TYR C 238
 None
None
BSU  C 401 (-3.8A)
BSU  C 401 (-2.8A)
BSU  C 401 (-4.4A)
 1.20A 1zz1A-5cw2C:
undetectable		 1zz1A-5cw2C:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 VAL C 284
THR C 280
PRO C 130
ALA C 113
PRO C 286
 None
 1.20A 2admB-5cw2C:
undetectable		 2admB-5cw2C:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.80A 2avvA-5cw2C:
undetectable		 2avvA-5cw2C:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.83A 2avvE-5cw2C:
undetectable		 2avvE-5cw2C:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 PRO C 197
GLY C 196
ASP C 202
PHE C 152
PHE C 157
 None
 1.47A 2b9eA-5cw2C:
undetectable		 2b9eA-5cw2C:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.84A 2f80A-5cw2C:
undetectable		 2f80A-5cw2C:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.89A 2f81A-5cw2C:
undetectable		 2f81A-5cw2C:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.80A 2hs1B-5cw2C:
undetectable		 2hs1B-5cw2C:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.82A 2hs2B-5cw2C:
undetectable		 2hs2B-5cw2C:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 9 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.94A 2idwB-5cw2C:
undetectable		 2idwB-5cw2C:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 5 ALA C 264
ALA C 279
ALA C 283
VAL C 123
 None
 0.68A 2nyrB-5cw2C:
2.6		 2nyrB-5cw2C:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.79A 2q64A-5cw2C:
undetectable		 2q64A-5cw2C:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.80A 2rkfA-5cw2C:
undetectable		 2rkfA-5cw2C:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.81A 2rkgB-5cw2C:
undetectable		 2rkgB-5cw2C:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 MET C 192
GLU C 166
ASP C 164
 None
 1.03A 3a25A-5cw2C:
undetectable		 3a25A-5cw2C:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 LEU C  16
TRP C  42
TYR C  64
 None
 0.93A 3aicA-5cw2C:
undetectable		 3aicA-5cw2C:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 LEU C  16
TRP C  42
TYR C  64
 None
 0.95A 3aicB-5cw2C:
undetectable		 3aicB-5cw2C:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 LEU C  16
TRP C  42
TYR C  64
 None
 0.92A 3aicE-5cw2C:
undetectable		 3aicE-5cw2C:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 LEU C  16
TRP C  42
TYR C  64
 None
 0.92A 3aicF-5cw2C:
undetectable		 3aicF-5cw2C:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 LEU C  16
TRP C  42
TYR C  64
 None
 0.92A 3aicG-5cw2C:
undetectable		 3aicG-5cw2C:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 LEU C  16
TRP C  42
TYR C  64
 None
 0.91A 3aicH-5cw2C:
undetectable		 3aicH-5cw2C:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.76A 3d1xB-5cw2C:
undetectable		 3d1xB-5cw2C:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.86A 3d20A-5cw2C:
undetectable		 3d20A-5cw2C:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 10 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.88A 3ekpD-5cw2C:
undetectable		 3ekpD-5cw2C:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.90A 3ektC-5cw2C:
undetectable		 3ektC-5cw2C:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.87A 3ektD-5cw2C:
undetectable		 3ektD-5cw2C:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.80A 3el1A-5cw2C:
undetectable		 3el1A-5cw2C:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.84A 3lzsB-5cw2C:
undetectable		 3lzsB-5cw2C:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.82A 3lzuA-5cw2C:
undetectable		 3lzuA-5cw2C:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.87A 3mwsA-5cw2C:
undetectable		 3mwsA-5cw2C:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 TYR C  76
LEU C  81
PHE C 226
GLY C  65
LEU C  16
 None
 1.00A 3n8xB-5cw2C:
undetectable		 3n8xB-5cw2C:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.78A 3nduA-5cw2C:
undetectable		 3nduA-5cw2C:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.77A 3nduB-5cw2C:
undetectable		 3nduB-5cw2C:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 GLU C 302
THR C 183
ALA C 295
ALA C 267
 None
 1.17A 3ns1C-5cw2C:
undetectable		 3ns1C-5cw2C:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.78A 3nu3A-5cw2C:
undetectable		 3nu3A-5cw2C:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.75A 3nu3B-5cw2C:
undetectable		 3nu3B-5cw2C:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 9 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.78A 3nu4B-5cw2C:
undetectable		 3nu4B-5cw2C:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 9 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.80A 3nujB-5cw2C:
undetectable		 3nujB-5cw2C:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 9 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.77A 3nuoB-5cw2C:
undetectable		 3nuoB-5cw2C:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.78A 3pwmA-5cw2C:
undetectable		 3pwmA-5cw2C:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.86A 3pwmB-5cw2C:
undetectable		 3pwmB-5cw2C:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.85A 3pwrA-5cw2C:
undetectable		 3pwrA-5cw2C:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.74A 3pwrB-5cw2C:
undetectable		 3pwrB-5cw2C:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 ASP C 268
PHE C 262
LEU C 271
PHE C 142
ILE C 154
 None
 0.97A 3pwwA-5cw2C:
undetectable		 3pwwA-5cw2C:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 10 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.78A 3s43B-5cw2C:
undetectable		 3s43B-5cw2C:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.88A 3tkwA-5cw2C:
undetectable		 3tkwA-5cw2C:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 ALA C 163
GLU C 166
ILE C 201
PHE C 200
LEU C 182
 None
None
None
None
BSU  C 401 ( 4.9A)
 1.04A 4cd2A-5cw2C:
undetectable		 4cd2A-5cw2C:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.74A 4hlaA-5cw2C:
undetectable		 4hlaA-5cw2C:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.77A 4hlaB-5cw2C:
undetectable		 4hlaB-5cw2C:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		6 / 12 ASP C 103
TYR C 153
PHE C 157
TYR C 238
HIS C 297
TRP C 298
 BSU  C 401 (-2.8A)
BSU  C 401 (-4.4A)
None
BSU  C 401 (-4.4A)
BSU  C 401 (-3.8A)
None
 0.38A 4j03A-5cw2C:
39.6		 4j03A-5cw2C:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.75A 4jecB-5cw2C:
undetectable		 4jecB-5cw2C:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 10 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.89A 4ll3B-5cw2C:
undetectable		 4ll3B-5cw2C:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 10 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.86A 4ll3A-5cw2C:
undetectable		 4ll3A-5cw2C:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 VAL C 290
GLY C 265
ASP C 268
PHE C 262
GLY C 125
 None
 1.25A 4pevB-5cw2C:
5.0		 4pevB-5cw2C:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 9 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.77A 4rvjB-5cw2C:
undetectable		 4rvjB-5cw2C:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 9 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.77A 4rvjD-5cw2C:
undetectable		 4rvjD-5cw2C:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.78A 5e5jA-5cw2C:
undetectable		 5e5jA-5cw2C:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.76A 5e5kB-5cw2C:
undetectable		 5e5kB-5cw2C:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 VAL C 299
LEU C 291
ALA C 264
SER C 127
LEU C 261
 None
 1.21A 5nd7B-5cw2C:
3.0		 5nd7B-5cw2C:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 10 LEU C  31
HIS C  33
ILE C 100
GLY C 101
GLY C 105
 None
 0.83A 5o96C-5cw2C:
undetectable
5o96D-5cw2C:
undetectable		 5o96C-5cw2C:
22.55
5o96D-5cw2C:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.76A 5t8hA-5cw2C:
undetectable		 5t8hA-5cw2C:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 LEU C 311
LEU C 315
ALA C 122
ALA C  98
 None
 0.89A 6a7jA-5cw2C:
undetectable		 6a7jA-5cw2C:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU C 315
GLY C  53
ALA C  52
ILE C  46
ILE C 312
 None
 0.81A 6dh3B-5cw2C:
undetectable		 6dh3B-5cw2C:
15.46