SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cw9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W3B_B_FOLB401_1 (DIHYDROFOLATE REDUCTASE)	5cw9	DE NOVO DESIGNED FERREDOXIN-FERREDOXI N DOMAIN INSERTION PROTEIN (synthetic construct)	3 / 3	GLU A 101 GLN A 59 ARG A 58	None	0.89A	2w3bB-5cw9A: undetectable	2w3bB-5cw9A: 21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KR3_A_GLYA701_0 (GLYCINE--TRNA LIGASE)	5cw9	DE NOVO DESIGNED FERREDOXIN-FERREDOXI N DOMAIN INSERTION PROTEIN (synthetic construct)	4 / 6	GLU A 55 ARG A 58 ARG A 97 GLU A 94	None	1.15A	4kr3A-5cw9A: 1.8	4kr3A-5cw9A: 14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NM5_B_LOCB502_2 (TUBULIN BETA-2B CHAIN)	5cw9	DE NOVO DESIGNED FERREDOXIN-FERREDOXI N DOMAIN INSERTION PROTEIN (synthetic construct)	5 / 12	LEU A 53 LEU A 98 ILE A 39 ALA A 95 ILE A 80	None	1.11A	5nm5B-5cw9A: undetectable	5nm5B-5cw9A: 14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BPL_B_PA1B605_1 (LIPID A EXPORT ATP-BINDING/PERMEASE PROTEIN MSBA)	5cw9	DE NOVO DESIGNED FERREDOXIN-FERREDOXI N DOMAIN INSERTION PROTEIN (synthetic construct)	3 / 3	ARG A 8 ARG A 79 ARG A 6	None	0.99A	6bplA-5cw9A: undetectable 6bplB-5cw9A: undetectable	6bplA-5cw9A: 20.29 6bplB-5cw9A: 20.29

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2W3B_B_FOLB401_1","DIHYDROFOLATE REDUCTASE","5cw9","DE NOVO DESIGNED FERREDOXIN-FERREDOXIN DOMAIN INSERTION PROTEIN","synthetic construct",3,"GLU A 101;GLN A  59;ARG A  58","None","0.89A","2w3bB-5cw9A:undetectable","2w3bB-5cw9A:21.36"],["4KR3_A_GLYA701_0","GLYCINE--TRNA LIGASE","5cw9","DE NOVO DESIGNED FERREDOXIN-FERREDOXIN DOMAIN INSERTION PROTEIN","synthetic construct",4,"GLU A  55;ARG A  58;ARG A  97;GLU A  94","None","1.15A","4kr3A-5cw9A:1.8","4kr3A-5cw9A:14.67"],["5NM5_B_LOCB502_2","TUBULIN BETA-2B CHAIN","5cw9","DE NOVO DESIGNED FERREDOXIN-FERREDOXIN DOMAIN INSERTION PROTEIN","synthetic construct",5,"LEU A  53;LEU A  98;ILE A  39;ALA A  95;ILE A  80","None","1.11A","5nm5B-5cw9A:undetectable","5nm5B-5cw9A:14.54"],["6BPL_B_PA1B605_1","LIPID A EXPORT ATP-BINDING\/PERMEASE PROTEIN MSBA;LIPID A EXPORT ATP-BINDING\/PERMEASE PROTEIN MSBA","5cw9","DE NOVO DESIGNED FERREDOXIN-FERREDOXIN DOMAIN INSERTION PROTEIN","synthetic construct",3,"ARG A   8;ARG A  79;ARG A   6","None","0.99A","6bplA-5cw9A:undetectable;6bplB-5cw9A:undetectable","6bplA-5cw9A:20.29;6bplB-5cw9A:20.29"]]