SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cwb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 5cwb DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 12 GLU A 193
VAL A 192
ILE A 139
VAL A 168
ILE A 167
 None
 1.15A 1c9hA-5cwbA:
undetectable		 1c9hA-5cwbA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5cwb DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		3 / 3 TYR A 103
GLU A 154
TYR A 153
 None
 0.85A 3ug8A-5cwbA:
undetectable		 3ug8A-5cwbA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5cwb DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 8 SER A  49
GLU A  48
ILE A  63
VAL A  14
 None
 0.93A 4dx7B-5cwbA:
5.3		 4dx7B-5cwbA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5cwb DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 8 SER A 199
GLU A 198
ILE A 163
VAL A 114
 None
 0.98A 4dx7B-5cwbA:
5.3		 4dx7B-5cwbA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 5cwb DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 9 ALA A  70
ILE A  63
ILE A 117
ILE A  31
VAL A  18
 None
 1.12A 4nptA-5cwbA:
undetectable		 4nptA-5cwbA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 5cwb DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 5 GLU A  66
ALA A  65
GLU A  69
GLU A   8
 None
 1.25A 5dwkC-5cwbA:
2.4		 5dwkC-5cwbA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 5cwb DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 12 GLU A 193
VAL A 192
ILE A 139
VAL A 168
ILE A 167
 None
 1.14A 5hkgA-5cwbA:
undetectable		 5hkgA-5cwbA:
17.87