SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cwc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 5cwc DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 11 ALA A  95
ALA A  98
ALA A 145
LEU A 106
VAL A 105
 None
 1.06A 2bxeB-5cwcA:
2.8		 2bxeB-5cwcA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 5cwc DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 10 ALA A  95
ALA A  98
ALA A 145
LEU A 106
VAL A 105
 None
 1.00A 2bxgB-5cwcA:
3.7		 2bxgB-5cwcA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 5cwc DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 9 PHE A  88
GLU A  65
ILE A 113
ALA A  87
PHE A 138
 None
 1.10A 2drdA-5cwcA:
2.9		 2drdA-5cwcA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 5cwc DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 11 ALA A  87
ILE A 127
ILE A 113
ALA A 134
ALA A 130
 None
 1.11A 2qhfA-5cwcA:
undetectable		 2qhfA-5cwcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5cwc DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 7 ALA A  84
ALA A  83
ALA A  87
GLN A 121
 None
 0.86A 3a2qA-5cwcA:
undetectable		 3a2qA-5cwcA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5cwc DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 ILE A 127
SER A 128
ASP A  76
ASP A  26
 None
 1.24A 4krhB-5cwcA:
undetectable		 4krhB-5cwcA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5cwc DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 7 GLU A 104
GLU A 107
GLU A 161
ARG A 111
 None
 1.10A 4mi4B-5cwcA:
undetectable
4mi4C-5cwcA:
undetectable		 4mi4B-5cwcA:
21.78
4mi4C-5cwcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5cwc DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 8 GLU A 104
GLU A 107
GLU A 161
ARG A 111
 None
 1.10A 4mj8B-5cwcA:
undetectable
4mj8C-5cwcA:
undetectable		 4mj8B-5cwcA:
25.00
4mj8C-5cwcA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5cwc DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		3 / 3 ARG A 140
ARG A  97
ARG A  90
 None
 0.84A 5vcgA-5cwcA:
undetectable		 5vcgA-5cwcA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5cwc DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 7 ILE A  63
LEU A  62
CYH A  66
ALA A 134
 None
 0.72A 6b5vA-5cwcA:
undetectable
6b5vC-5cwcA:
undetectable		 6b5vA-5cwcA:
16.58
6b5vC-5cwcA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5cwc DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 7 ILE A  63
LEU A  62
CYH A  66
ALA A 134
 None
 0.73A 6b5vC-5cwcA:
undetectable
6b5vD-5cwcA:
0.3		 6b5vC-5cwcA:
16.58
6b5vD-5cwcA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5cwc DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 7 ALA A 134
ILE A  63
LEU A  62
CYH A  66
 None
 0.72A 6b5vB-5cwcA:
undetectable
6b5vD-5cwcA:
undetectable		 6b5vB-5cwcA:
16.58
6b5vD-5cwcA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5cwc DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 ALA A  48
ALA A  45
ALA A  92
ALA A  95
 None
 0.84A 6gtqA-5cwcA:
undetectable
6gtqB-5cwcA:
undetectable		 6gtqA-5cwcA:
23.22
6gtqB-5cwcA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5cwc DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 ALA A  92
ALA A  95
ALA A  48
ALA A  45
 None
 0.83A 6gtqA-5cwcA:
undetectable
6gtqB-5cwcA:
undetectable		 6gtqA-5cwcA:
23.22
6gtqB-5cwcA:
23.22