SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cwe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 9 ILE A 229
PHE A 102
LEU A 149
GLY A 346
ALA A 233
 HEM  A 403 (-4.7A)
HEM  A 403 (-4.6A)
None
HEM  A 403 (-3.6A)
DAO  A 402 (-3.6A)
 1.04A 1e7bA-5cweA:
undetectable		 1e7bA-5cweA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 11 LEU A 370
LEU A 249
ALA A 261
VAL A 246
LEU A 368
 None
 1.47A 1kt6A-5cweA:
undetectable		 1kt6A-5cweA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		3 / 3 GLN A 332
HIS A 319
ARG A 314
 None
 0.85A 1zlqA-5cweA:
undetectable		 1zlqA-5cweA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 11 ALA A  56
GLY A 340
ILE A 341
ALA A 283
ILE A 307
 None
None
None
HEM  A 403 ( 3.7A)
None
 0.96A 2idwA-5cweA:
undetectable		 2idwA-5cweA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		3 / 3 ASP A 215
ARG A  93
ARG A 217
 None
 1.02A 2j9dA-5cweA:
undetectable
2j9dC-5cweA:
undetectable		 2j9dA-5cweA:
13.99
2j9dC-5cweA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		3 / 3 ARG A 275
ASN A 240
THR A 248
 None
 0.83A 2q63A-5cweA:
undetectable		 2q63A-5cweA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 8 THR A 103
LEU A 149
ASP A 201
GLU A 108
 None
 1.01A 2zw9A-5cweA:
undetectable		 2zw9A-5cweA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		3 / 3 ALA A 233
THR A 237
CYH A 344
 DAO  A 402 (-3.6A)
HEM  A 403 ( 3.6A)
HEM  A 403 (-2.0A)
 0.37A 3e4eA-5cweA:
32.4		 3e4eA-5cweA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		3 / 3 ALA A 233
THR A 237
CYH A 344
 DAO  A 402 (-3.6A)
HEM  A 403 ( 3.6A)
HEM  A 403 (-2.0A)
 0.31A 3e4eB-5cweA:
32.3		 3e4eB-5cweA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 9 ALA A  56
GLY A 340
ILE A 341
ALA A 283
ILE A 307
 None
None
None
HEM  A 403 ( 3.7A)
None
 1.03A 3ektB-5cweA:
undetectable		 3ektB-5cweA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 10 ALA A  56
GLY A 340
ILE A 341
ALA A 283
ILE A 307
 None
None
None
HEM  A 403 ( 3.7A)
None
 0.97A 3ekwA-5cweA:
undetectable		 3ekwA-5cweA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		3 / 3 ALA A  56
ARG A 286
LYS A  64
 None
HEM  A 403 (-2.8A)
HEM  A 403 ( 4.2A)
 0.89A 3kp3B-5cweA:
undetectable		 3kp3B-5cweA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 4 PRO A 304
LEU A  62
HIS A 342
LEU A  83
 None
None
HEM  A 403 (-3.9A)
HEM  A 403 (-3.8A)
 1.50A 3vw7A-5cweA:
0.0		 3vw7A-5cweA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 ASP A 132
THR A 243
VAL A 239
ASP A 135
GLU A 236
 None
 1.19A 4i41A-5cweA:
undetectable		 4i41A-5cweA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 6 ARG A 286
HIS A  91
ARG A  95
ILE A 341
 HEM  A 403 (-2.8A)
HEM  A 403 (-3.9A)
HEM  A 403 (-3.8A)
None
 1.34A 5a06A-5cweA:
undetectable		 5a06A-5cweA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 349
ALA A 350
GLU A 353
GLY A 278
LEU A 274
 HEM  A 403 ( 4.9A)
HEM  A 403 (-3.3A)
None
None
None
 1.13A 5gtrA-5cweA:
2.1		 5gtrA-5cweA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 207
LEU A 218
ILE A 229
LEU A 150
LEU A 187
 None
None
HEM  A 403 (-4.7A)
None
None
 1.15A 5og9B-5cweA:
32.4		 5og9B-5cweA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 5 TYR A  22
ASP A 315
PRO A 316
ALA A 312
 None
 0.93A 5otrA-5cweA:
undetectable		 5otrA-5cweA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 ALA A 311
LEU A 335
ILE A 294
LEU A  57
LEU A  46
 None
 1.02A 5toaA-5cweA:
undetectable		 5toaA-5cweA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		3 / 3 GLU A  90
HIS A  91
VAL A  86
 None
HEM  A 403 (-3.9A)
None
 0.63A 5trqB-5cweA:
undetectable		 5trqB-5cweA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 7 ARG A 113
GLU A 148
LEU A 121
ARG A 157
 None
 1.05A 5umwB-5cweA:
undetectable
5umwE-5cweA:
undetectable		 5umwB-5cweA:
11.81
5umwE-5cweA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 204
ALA A 227
LEU A 190
THR A 159
ILE A 155
 None
 1.18A 5xiwD-5cweA:
undetectable		 5xiwD-5cweA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		3 / 3 SER A 164
HIS A 235
TYR A 139
 None
 1.03A 5y2tA-5cweA:
undetectable		 5y2tA-5cweA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 8 GLY A 308
ILE A 307
ASP A 315
HIS A  50
 None
 0.86A 6ag0A-5cweA:
undetectable		 6ag0A-5cweA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 8 GLY A 308
ILE A 307
ASP A 315
HIS A  50
 None
 0.90A 6ag0C-5cweA:
undetectable		 6ag0C-5cweA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 6 VAL A 246
LEU A 259
LEU A 256
HIS A 252
 None
 1.00A 6e43A-5cweA:
undetectable		 6e43A-5cweA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 6 VAL A 246
LEU A 259
LEU A 256
HIS A 252
 None
 1.01A 6e43B-5cweA:
undetectable		 6e43B-5cweA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 6 VAL A 246
LEU A 259
LEU A 256
HIS A 252
 None
 1.00A 6e43C-5cweA:
undetectable		 6e43C-5cweA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 10 VAL A 391
LEU A 368
LEU A 361
LEU A 249
LEU A 250
 None
 1.01A 6f6nA-5cweA:
undetectable
6f6nB-5cweA:
undetectable		 6f6nA-5cweA:
11.43
6f6nB-5cweA:
10.18