SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cwf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5cwf DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 11 LEU A 145
LEU A 100
ALA A  58
ALA A  56
LEU A 152
 None
 1.38A 1iiuA-5cwfA:
undetectable		 1iiuA-5cwfA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 5cwf DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		3 / 3 ASN A 112
ALA A 118
ASN A  68
 None
 0.82A 1n4fA-5cwfA:
undetectable		 1n4fA-5cwfA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 5cwf DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 7 GLU A 165
ARG A 150
ASP A 153
ALA A 154
 None
 1.18A 4zz8A-5cwfA:
undetectable		 4zz8A-5cwfA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 5cwf DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 8 ILE A 121
ILE A 128
ALA A 167
ILE A 166
 None
 0.77A 5mvmA-5cwfA:
undetectable
5mvmB-5cwfA:
2.1		 5mvmA-5cwfA:
16.23
5mvmB-5cwfA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 5cwf DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 LEU A  57
MET A   5
ILE A  76
LEU A  12
 None
 1.27A 5nfpA-5cwfA:
undetectable		 5nfpA-5cwfA:
18.79