SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cwi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5cwi DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 8 GLU A  73
SER A 199
GLU A 136
GLU A  76
 None
 1.14A 1knyA-5cwiA:
1.8
1knyB-5cwiA:
2.9		 1knyA-5cwiA:
23.47
1knyB-5cwiA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5cwi DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 5 ALA A 107
ALA A 195
ALA A 194
VAL A 228
 None
 0.83A 2nyrB-5cwiA:
undetectable		 2nyrB-5cwiA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5cwi DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 5 ALA A 137
ALA A 195
GLN A 103
VAL A 168
 None
 0.92A 2nyrB-5cwiA:
undetectable		 2nyrB-5cwiA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5cwi DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 5 ALA A 138
ALA A 134
GLN A  43
VAL A 108
 None
 0.88A 2nyrB-5cwiA:
undetectable		 2nyrB-5cwiA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5cwi DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 5 ALA A 198
ALA A 194
GLN A 103
VAL A 168
 None
 0.82A 2nyrB-5cwiA:
undetectable		 2nyrB-5cwiA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5cwi DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 ALA A  74
ALA A  77
ALA A  78
ALA A  81
 None
 0.08A 4oadA-5cwiA:
undetectable		 4oadA-5cwiA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5cwi DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 ALA A 134
ALA A 137
ALA A 138
ALA A 141
 None
 0.11A 4oadA-5cwiA:
undetectable		 4oadA-5cwiA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5cwi DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 ALA A 198
ALA A 201
ALA A 202
ALA A 205
 None
 0.11A 4oadA-5cwiA:
undetectable		 4oadA-5cwiA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5cwi DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 ALA A  74
ALA A  77
ALA A  78
ALA A  81
 None
 0.05A 4oaeA-5cwiA:
undetectable		 4oaeA-5cwiA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5cwi DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 ALA A 134
ALA A 137
ALA A 138
ALA A 141
 None
 0.08A 4oaeA-5cwiA:
undetectable		 4oaeA-5cwiA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5cwi DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 ALA A 198
ALA A 201
ALA A 202
ALA A 205
 None
 0.13A 4oaeA-5cwiA:
undetectable		 4oaeA-5cwiA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5cwi DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 9 ALA A  94
ALA A  33
ALA A  37
SER A 102
ALA A  97
 None
 1.27A 4twdA-5cwiA:
4.2
4twdB-5cwiA:
3.0
4twdC-5cwiA:
4.1
4twdD-5cwiA:
4.2
4twdE-5cwiA:
3.9		 4twdA-5cwiA:
18.10
4twdB-5cwiA:
18.10
4twdC-5cwiA:
18.10
4twdD-5cwiA:
18.10
4twdE-5cwiA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5cwi DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 9 ALA A 145
ALA A 142
ALA A  81
ALA A  93
SER A  91
 None
 1.25A 4twdA-5cwiA:
4.2
4twdB-5cwiA:
3.0
4twdC-5cwiA:
4.1
4twdD-5cwiA:
4.2
4twdE-5cwiA:
3.9		 4twdA-5cwiA:
18.10
4twdB-5cwiA:
18.10
4twdC-5cwiA:
18.10
4twdD-5cwiA:
18.10
4twdE-5cwiA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 5cwi DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 6 ALA A 154
GLN A  92
SER A  91
ASP A 150
 None
 1.23A 5c6pA-5cwiA:
3.0		 5c6pA-5cwiA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 5cwi DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 12 LEU A 100
ALA A  97
GLU A 136
ALA A  47
ALA A 105
 None
 1.16A 5n5dB-5cwiA:
undetectable		 5n5dB-5cwiA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 5cwi DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 12 LEU A 160
ALA A 157
GLU A 196
ALA A 107
ALA A 165
 None
 0.95A 5n5dB-5cwiA:
undetectable		 5n5dB-5cwiA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 5cwi DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 12 CYH A 127
LEU A 114
ASN A 180
ALA A 184
ILE A 188
 None
 1.16A 5nm5B-5cwiA:
undetectable		 5nm5B-5cwiA:
19.33