SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cwk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERR_B_CCSB381_0 (ESTROGEN RECEPTOR)	5cwk	DESIGNED HELICAL REPEAT PROTEIN (synthetic construct)	3 / 3	GLU A 139 ALA A 134 SER A 131	None	0.63A	1errB-5cwkA: undetectable	1errB-5cwkA: 21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2R2V_D_ACTD37_0 (GCN4 LEUCINE ZIPPER)	5cwk	DESIGNED HELICAL REPEAT PROTEIN (synthetic construct)	3 / 3	LYS A 76 ARG A 33 VAL A 32	None	1.01A	2r2vC-5cwkA: undetectable 2r2vD-5cwkA: undetectable	2r2vC-5cwkA: 16.78 2r2vD-5cwkA: 16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K6I_A_9RAA500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5cwk	DESIGNED HELICAL REPEAT PROTEIN (synthetic construct)	5 / 12	ALA A 91 ALA A 94 LEU A 56 ILE A 55 VAL A 39	None	0.92A	4k6iA-5cwkA: undetectable	4k6iA-5cwkA: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K6I_A_9RAA500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5cwk	DESIGNED HELICAL REPEAT PROTEIN (synthetic construct)	5 / 12	ALA A 134 ALA A 137 LEU A 99 ILE A 98 VAL A 82	None	1.12A	4k6iA-5cwkA: undetectable	4k6iA-5cwkA: 22.03

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ERR_B_CCSB381_0","ESTROGEN RECEPTOR","5cwk","DESIGNED HELICAL REPEAT PROTEIN","synthetic construct",3,"GLU A 139;ALA A 134;SER A 131","None","0.63A","1errB-5cwkA:undetectable","1errB-5cwkA:21.92"],["2R2V_D_ACTD37_0","GCN4 LEUCINE ZIPPER","5cwk","DESIGNED HELICAL REPEAT PROTEIN","synthetic construct",3,"LYS A  76;ARG A  33;VAL A  32","None","1.01A","2r2vC-5cwkA:undetectable;2r2vD-5cwkA:undetectable","2r2vC-5cwkA:16.78;2r2vD-5cwkA:16.78"],["4K6I_A_9RAA500_1","RETINOIC ACID RECEPTOR RXR-ALPHA","5cwk","DESIGNED HELICAL REPEAT PROTEIN","synthetic construct",5,"ALA A  91;ALA A  94;LEU A  56;ILE A  55;VAL A  39","None","0.92A","4k6iA-5cwkA:undetectable","4k6iA-5cwkA:22.03"],["4K6I_A_9RAA500_1","RETINOIC ACID RECEPTOR RXR-ALPHA","5cwk","DESIGNED HELICAL REPEAT PROTEIN","synthetic construct",5,"ALA A 134;ALA A 137;LEU A  99;ILE A  98;VAL A  82","None","1.12A","4k6iA-5cwkA:undetectable","4k6iA-5cwkA:22.03"]]