SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cwl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5cwl DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 10 ALA A 100
GLU A  97
LEU A 137
ILE A 168
LEU A 119
 None
 1.38A 1a52A-5cwlA:
undetectable		 1a52A-5cwlA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5cwl DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 10 ALA A 100
GLU A  97
LEU A 137
ILE A 168
LEU A 119
 None
 1.36A 1a52B-5cwlA:
undetectable		 1a52B-5cwlA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5cwl DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 9 ALA A 100
GLU A  97
LEU A 137
ILE A 168
LEU A 119
 None
 1.40A 1ereA-5cwlA:
undetectable		 1ereA-5cwlA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 5cwl DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 9 ALA A 100
GLU A  97
LEU A 137
ILE A 168
LEU A 119
 None
 1.41A 1ereB-5cwlA:
undetectable		 1ereB-5cwlA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 5cwl DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 9 ALA A 100
GLU A  97
LEU A 137
ILE A 168
LEU A 119
 None
 1.40A 1ereC-5cwlA:
undetectable		 1ereC-5cwlA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 5cwl DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 9 ALA A 100
GLU A  97
LEU A 137
ILE A 168
LEU A 119
 None
 1.41A 1ereD-5cwlA:
undetectable		 1ereD-5cwlA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 5cwl DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 ASN A  68
ALA A  21
GLY A  24
THR A  26
 None
 1.36A 4bboC-5cwlA:
undetectable		 4bboC-5cwlA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 5cwl DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 12 LEU A 119
ALA A 122
VAL A 121
GLU A 148
ALA A 114
 None
 1.12A 5n5dB-5cwlA:
2.2		 5n5dB-5cwlA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5cwl DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 5 LEU A 123
ALA A 138
LEU A 139
LEU A  96
 None
 0.71A 5vkqA-5cwlA:
3.2
5vkqD-5cwlA:
5.3		 5vkqA-5cwlA:
7.45
5vkqD-5cwlA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5cwl DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 5 LEU A  96
LEU A 123
ALA A 138
LEU A 139
 None
 0.71A 5vkqA-5cwlA:
3.2
5vkqB-5cwlA:
3.3		 5vkqA-5cwlA:
7.45
5vkqB-5cwlA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5cwl DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 5 LEU A  96
LEU A 123
ALA A 138
LEU A 139
 None
 0.68A 5vkqB-5cwlA:
3.3
5vkqC-5cwlA:
3.2		 5vkqB-5cwlA:
7.45
5vkqC-5cwlA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5cwl DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 5 LEU A  96
LEU A 123
ALA A 138
LEU A 139
 None
 0.75A 5vkqC-5cwlA:
3.2
5vkqD-5cwlA:
5.3		 5vkqC-5cwlA:
7.45
5vkqD-5cwlA:
7.45