SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cwm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 5cwm DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		3 / 3 GLU A 208
ALA A 203
SER A 200
 None
 0.67A 1errB-5cwmA:
undetectable		 1errB-5cwmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5cwm DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 7 VAL A 187
LEU A 108
ALA A 161
LEU A 183
 None
 0.77A 1pthA-5cwmA:
undetectable		 1pthA-5cwmA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5cwm DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 7 VAL A 187
LEU A 108
ALA A 161
LEU A 183
 None
 0.77A 1pthB-5cwmA:
undetectable		 1pthB-5cwmA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 5cwm DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 11 ALA A  97
ILE A 137
ALA A 146
ALA A 150
VAL A 153
 None
 0.76A 2qhfA-5cwmA:
undetectable		 2qhfA-5cwmA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5cwm DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 6 ASP A   2
GLU A  57
ASP A  59
GLU A  61
 None
 1.29A 6mn5C-5cwmA:
undetectable		 6mn5C-5cwmA:
16.08