SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cwn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_A_T44A428_1
(TRANSTHYRETIN
THR119MET VARIANT)		 5cwn DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 LYS A  61
LEU A  57
ALA A  60
LEU A  93
 None
 1.09A 1f86A-5cwnA:
undetectable		 1f86A-5cwnA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 5cwn DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 LYS A  11
LEU A   7
ALA A  10
LEU A  43
 None
 1.21A 1f86B-5cwnA:
undetectable		 1f86B-5cwnA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 5cwn DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 LYS A  61
LEU A  57
ALA A  60
LEU A  93
 None
 1.09A 1f86B-5cwnA:
undetectable		 1f86B-5cwnA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 5cwn DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 LYS A 111
LEU A 107
ALA A 110
LEU A 143
 None
 1.12A 1f86B-5cwnA:
undetectable		 1f86B-5cwnA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 5cwn DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 9 LEU A  64
LYS A  81
LEU A  37
GLU A  77
ALA A  83
 None
None
PG4  A 302 ( 3.8A)
None
None
 1.49A 1sn0A-5cwnA:
undetectable
1sn0C-5cwnA:
undetectable		 1sn0A-5cwnA:
21.11
1sn0C-5cwnA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5cwn DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		3 / 3 LYS A  35
ARG A   9
LYS A  49
 None
 1.48A 3okxA-5cwnA:
undetectable		 3okxA-5cwnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 5cwn DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 12 LEU A  87
ALA A  90
VAL A  89
ALA A  70
ALA A  82
 PG4  A 303 ( 3.7A)
None
PG4  A 301 ( 4.2A)
None
None
 1.14A 5n5dB-5cwnA:
undetectable		 5n5dB-5cwnA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 5cwn DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 12 LEU A 137
ALA A 140
VAL A 139
ALA A 120
ALA A 132
 None
 1.16A 5n5dB-5cwnA:
undetectable		 5n5dB-5cwnA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 5cwn DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 LYS A  11
LEU A   7
ALA A  10
LEU A  43
 None
 1.29A 6gnrA-5cwnA:
undetectable		 6gnrA-5cwnA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 5cwn DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 4 LYS A  11
LEU A   7
ALA A  10
LEU A  43
 None
 1.27A 6gnrB-5cwnA:
undetectable		 6gnrB-5cwnA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5cwn DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 6 ASP A  52
GLU A 100
ASP A 102
GLU A 104
 None
 1.28A 6mn5C-5cwnA:
undetectable		 6mn5C-5cwnA:
17.20