SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cwo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N4H_A_REAA500_1 (NUCLEAR RECEPTOR ROR-BETA)	5cwo	DESIGNED HELICAL REPEAT PROTEIN (synthetic construct)	5 / 11	GLN A 110 ILE A 104 ALA A 107 VAL A 116 ALA A 123	None	1.14A	1n4hA-5cwoA: undetectable	1n4hA-5cwoA: 22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KW4_A_TICA600_1 (CYTOCHROME P450 2B4)	5cwo	DESIGNED HELICAL REPEAT PROTEIN (synthetic construct)	5 / 11	ILE A 104 ILE A 75 ALA A 67 GLU A 73 VAL A 19	None	0.93A	3kw4A-5cwoA: undetectable	3kw4A-5cwoA: 18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OQR_A_2UOA502_1 (CYP105AS1)	5cwo	DESIGNED HELICAL REPEAT PROTEIN (synthetic construct)	5 / 9	VAL A 97 ILE A 49 VAL A 64 ALA A 65 ALA A 71	None	1.04A	4oqrA-5cwoA: undetectable	4oqrA-5cwoA: 20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z3O_F_MFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE E-SITE DNA)	5cwo	DESIGNED HELICAL REPEAT PROTEIN (synthetic construct)	4 / 5	ARG A 197 ARG A 142 GLY A 140 GLU A 137	None	1.13A	4z3oA-5cwoA: undetectable 4z3oB-5cwoA: undetectable	4z3oA-5cwoA: 18.07 4z3oB-5cwoA: 18.07

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1N4H_A_REAA500_1","NUCLEAR RECEPTOR ROR-BETA","5cwo","DESIGNED HELICAL REPEAT PROTEIN","synthetic construct",5,"GLN A 110;ILE A 104;ALA A 107;VAL A 116;ALA A 123","None","1.14A","1n4hA-5cwoA:undetectable","1n4hA-5cwoA:22.30"],["3KW4_A_TICA600_1","CYTOCHROME P450 2B4","5cwo","DESIGNED HELICAL REPEAT PROTEIN","synthetic construct",5,"ILE A 104;ILE A  75;ALA A  67;GLU A  73;VAL A  19","None","0.93A","3kw4A-5cwoA:undetectable","3kw4A-5cwoA:18.80"],["4OQR_A_2UOA502_1","CYP105AS1","5cwo","DESIGNED HELICAL REPEAT PROTEIN","synthetic construct",5,"VAL A  97;ILE A  49;VAL A  64;ALA A  65;ALA A  71","None","1.04A","4oqrA-5cwoA:undetectable","4oqrA-5cwoA:20.30"],["4Z3O_F_MFXF101_1","DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE;DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE;E-SITE DNA","5cwo","DESIGNED HELICAL REPEAT PROTEIN","synthetic construct",4,"ARG A 197;ARG A 142;GLY A 140;GLU A 137","None","1.13A","4z3oA-5cwoA:undetectable;4z3oB-5cwoA:undetectable","4z3oA-5cwoA:18.07;4z3oB-5cwoA:18.07"]]