SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cwq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 5cwq DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 10 GLU A  75
GLU A  76
ALA A  77
LEU A  40
GLU A  68
 None
 1.37A 1a29A-5cwqA:
undetectable		 1a29A-5cwqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 5cwq DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 10 GLU A 132
GLU A 133
ALA A 134
LEU A  97
GLU A 125
 None
 1.39A 1a29A-5cwqA:
undetectable		 1a29A-5cwqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 5cwq DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 10 GLU A 196
ALA A 198
LEU A 154
GLU A 190
GLU A 188
 None
 1.47A 1a29A-5cwqA:
undetectable		 1a29A-5cwqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 5cwq DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 9 ALA A 141
GLU A 140
LEU A  93
ILE A  98
LEU A 154
 None
None
None
GOL  A 301 (-4.1A)
None
 1.49A 1ereB-5cwqA:
undetectable		 1ereB-5cwqA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 5cwq DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 12 ILE A 100
LEU A  40
ALA A  77
LEU A  93
LEU A 152
 None
 1.13A 1og5B-5cwqA:
undetectable		 1og5B-5cwqA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 5cwq DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 12 GLU A  68
GLU A 119
GLU A  64
ARG A 114
ASN A 116
 None
 1.46A 4b7qB-5cwqA:
undetectable		 4b7qB-5cwqA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 5cwq DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 12 LEU A 107
GLU A  68
ALA A 111
GLU A  64
ASN A 116
 None
 1.46A 4cpzB-5cwqA:
undetectable		 4cpzB-5cwqA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 5cwq DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 12 LEU A 164
GLU A 125
ALA A 168
GLU A 121
ASN A 173
 None
 1.47A 4cpzB-5cwqA:
undetectable		 4cpzB-5cwqA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 5cwq DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 12 LEU A 164
GLU A 125
ALA A 168
GLU A 121
ASN A 173
 None
 1.50A 4cpzD-5cwqA:
undetectable		 4cpzD-5cwqA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5cwq DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		4 / 8 GLU A 212
ILE A  41
GLU A  38
LEU A  97
 GOL  A 301 (-2.8A)
GOL  A 301 ( 4.2A)
None
None
 0.89A 4mj8A-5cwqA:
undetectable		 4mj8A-5cwqA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5cwq DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 9 ALA A  99
ALA A  37
ALA A  39
SER A  24
ALA A  44
 None
 1.32A 4twdA-5cwqA:
5.8
4twdB-5cwqA:
6.0
4twdC-5cwqA:
6.1
4twdD-5cwqA:
6.1
4twdE-5cwqA:
5.7		 4twdA-5cwqA:
18.71
4twdB-5cwqA:
18.71
4twdC-5cwqA:
18.71
4twdD-5cwqA:
18.71
4twdE-5cwqA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 5cwq DESIGNED HELICAL
REPEAT PROTEIN
(synthetic
construct) 		5 / 12 ALA A 184
TYR A 181
GLU A 132
ALA A 123
ALA A 163
 None
 1.11A 5n5dB-5cwqA:
undetectable		 5n5dB-5cwqA:
22.39