SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 5cws NUCLEOPORIN NSP1
NUCLEOPORIN NUP49
NUCLEOPORIN NUP57
(Chaetomium
thermophilum) 		5 / 9 HIS C 626
LEU E 287
ALA E 283
LEU D 438
LEU D 434
 None
 1.44A 1hwiA-5cwsC:
undetectable		 1hwiA-5cwsC:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5cws NUCLEOPORIN NSP1
NUCLEOPORIN NUP49
(Chaetomium
thermophilum) 		4 / 5 ILE D 283
ARG C 497
LEU C 499
ASN C 502
 None
 1.15A 1y0xX-5cwsD:
undetectable		 1y0xX-5cwsD:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5cws NUCLEOPORIN NSP1
(Chaetomium
thermophilum) 		4 / 5 TYR C 544
ARG C 543
THR C 538
LEU C 537
 None
 1.22A 2eimJ-5cwsC:
undetectable		 2eimJ-5cwsC:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5cws NUCLEOPORIN NSP1
(Chaetomium
thermophilum) 		4 / 5 TYR C 544
ARG C 543
THR C 538
LEU C 537
 None
 1.23A 2eimW-5cwsC:
undetectable		 2eimW-5cwsC:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 5cws NUCLEOPORIN NSP1
NUCLEOPORIN NIC96
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		3 / 3 ASN F 150
LEU F 146
HIS C 626
 None
 0.74A 2q6fB-5cwsF:
undetectable		 2q6fB-5cwsF:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 5cws NUCLEOPORIN NIC96
NUCLEOPORIN NSP1
NUCLEOPORIN NUP57
(Chaetomium
thermophilum) 		5 / 11 LEU E 294
LEU E 297
VAL E 301
ALA C 637
LEU F 180
 None
 1.13A 2q72A-5cwsE:
undetectable		 2q72A-5cwsE:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 5cws NUCLEOPORIN NSP1
NUCLEOPORIN NUP57
(Chaetomium
thermophilum) 		5 / 11 ARG E 197
LEU C 548
ALA E 203
ARG E 191
LEU C 541
 None
 1.42A 2v0mA-5cwsE:
undetectable		 2v0mA-5cwsE:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2001_1
(SERUM ALBUMIN)		 5cws NUCLEOPORIN NIC96
NUCLEOPORIN NUP49
NUCLEOPORIN NUP57
(Chaetomium
thermophilum) 		5 / 12 LEU D 434
ARG F 174
TYR E 290
ILE E 286
ARG D 439
 None
 1.08A 2vufA-5cwsD:
undetectable		 2vufA-5cwsD:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5cws NUCLEOPORIN NSP1
(Chaetomium
thermophilum) 		4 / 5 TYR C 544
ARG C 543
THR C 538
LEU C 537
 None
 1.25A 3ag2J-5cwsC:
2.1		 3ag2J-5cwsC:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5cws NUCLEOPORIN NSP1
(Chaetomium
thermophilum) 		4 / 5 TYR C 544
ARG C 543
THR C 538
LEU C 537
 None
 1.19A 3ag4J-5cwsC:
2.1		 3ag4J-5cwsC:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5cws NUCLEOPORIN NSP1
NUCLEOPORIN NIC96
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		4 / 8 HIS C 626
GLY C 625
ASN F 150
PHE F 143
 None
 1.32A 3ccfA-5cwsC:
undetectable		 3ccfA-5cwsC:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5cws NUCLEOPORIN NIC96
NUCLEOPORIN NSP1
NUCLEOPORIN NUP49
NUCLEOPORIN NUP57
(Chaetomium
thermophilum) 		5 / 12 SER D 444
ILE D 445
LEU E 297
LEU C 627
LEU F 177
 None
 1.23A 3cs8A-5cwsD:
undetectable		 3cs8A-5cwsD:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5cws NUCLEOPORIN NSP1
NUCLEOPORIN NUP57
(Chaetomium
thermophilum) 		4 / 6 LEU C 541
GLU C 545
ARG E 198
HIS E 201
 None
 1.28A 3ltwA-5cwsC:
undetectable		 3ltwA-5cwsC:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 5cws NUCLEOPORIN NUP57
(Chaetomium
thermophilum) 		4 / 7 LYS E 224
LEU E 223
GLU E 220
VAL E 208
 None
 1.15A 4tvtA-5cwsE:
undetectable		 4tvtA-5cwsE:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5cws NUCLEOPORIN NSP1
NUCLEOPORIN NUP57
(Chaetomium
thermophilum) 		5 / 12 LEU E 287
ALA E 283
THR C 617
GLY E 276
LEU E 275
 None
None
OS  C 701 (-3.2A)
None
None
 1.02A 5m5cB-5cwsE:
undetectable		 5m5cB-5cwsE:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5cws NUCLEOPORIN NSP1
NUCLEOPORIN NUP57
(Chaetomium
thermophilum) 		5 / 10 LEU E 287
ALA E 283
THR C 617
GLY E 276
LEU E 275
 None
None
OS  C 701 (-3.2A)
None
None
 1.04A 5m5cE-5cwsE:
undetectable		 5m5cE-5cwsE:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5cws NUCLEOPORIN NSP1
(Chaetomium
thermophilum) 		4 / 5 TYR C 544
ARG C 543
THR C 538
LEU C 537
 None
 1.22A 5wauJ-5cwsC:
undetectable		 5wauJ-5cwsC:
14.98