SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cwu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		5 / 12 LEU A1647
LEU A1646
SER A1632
VAL A1703
LEU A1757
 None
 1.31A 1db1A-5cwuA:
undetectable		 1db1A-5cwuA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		4 / 6 LEU A1688
ALA A1704
LEU A1757
VAL A1772
 None
 1.14A 1sn5A-5cwuA:
undetectable		 1sn5A-5cwuA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		3 / 3 ALA A1674
VAL A1664
TRP A1680
 None
 0.98A 1tkqA-5cwuA:
undetectable		 1tkqA-5cwuA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		4 / 4 LEU A1685
SER A1717
LEU A1707
LEU A1757
 None
 0.95A 1yajA-5cwuA:
undetectable		 1yajA-5cwuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		4 / 6 ARG A1759
GLU A1774
ASN A1708
ALA A1704
 None
 1.28A 2ejfB-5cwuA:
undetectable		 2ejfB-5cwuA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		5 / 12 LEU A1559
LEU A1515
ILE A1574
VAL A1580
LEU A1641
 None
None
GOL  A1901 (-4.6A)
None
None
 0.92A 2h42C-5cwuA:
undetectable		 2h42C-5cwuA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		5 / 11 LEU A1457
VAL A1561
CYH A1558
PHE A1487
LEU A1486
 None
 1.40A 3bgrA-5cwuA:
undetectable
3bgrB-5cwuA:
undetectable		 3bgrA-5cwuA:
20.57
3bgrB-5cwuA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		5 / 12 HIS A1649
LEU A1650
HIS A1640
ALA A1633
LEU A1555
 None
 1.29A 3tm4A-5cwuA:
undetectable		 3tm4A-5cwuA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		5 / 12 HIS A1649
LEU A1650
HIS A1640
ALA A1633
LEU A1555
 None
 1.29A 3tm4B-5cwuA:
undetectable		 3tm4B-5cwuA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		5 / 9 LEU A1550
ALA A1557
VAL A1519
LEU A1515
ILE A1554
 None
 1.45A 3wsjA-5cwuA:
undetectable		 3wsjA-5cwuA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		5 / 12 LEU A1631
LEU A1628
LEU A1625
ALA A1624
ALA A1586
 None
 1.09A 4fn9A-5cwuA:
undetectable		 4fn9A-5cwuA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		3 / 3 TRP A1777
GLN A1709
THR A1776
 None
 0.94A 4m2xA-5cwuA:
undetectable		 4m2xA-5cwuA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		5 / 11 VAL A1467
ALA A1466
PHE A1479
SER A1461
SER A1462
 None
 1.09A 4mmaA-5cwuA:
undetectable		 4mmaA-5cwuA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		4 / 8 ILE A1574
LEU A1515
LEU A1631
PHE A1627
 GOL  A1901 (-4.6A)
None
None
None
 0.73A 4qopC-5cwuA:
undetectable		 4qopC-5cwuA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		4 / 4 LEU A1623
VAL A1619
GLU A1622
ARG A1675
 None
 1.10A 4ww7A-5cwuA:
undetectable		 4ww7A-5cwuA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		3 / 3 LEU A1685
TYR A1677
SER A1717
 None
 0.77A 5iktA-5cwuA:
1.2		 5iktA-5cwuA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		4 / 5 HIS A1640
ASN A1573
VAL A1571
LEU A1631
 None
 1.37A 5xdhB-5cwuA:
undetectable		 5xdhB-5cwuA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 5cwu NUCLEOPORIN NUP188
(Chaetomium
thermophilum) 		4 / 5 HIS A1640
ASN A1573
VAL A1571
LEU A1631
 None
 1.37A 5xdhD-5cwuA:
undetectable		 5xdhD-5cwuA:
10.03