SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cwv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 10 VAL A1596
LEU A1597
LEU A1729
GLY A1647
ALA A1648
 None
 1.13A 1pxxA-5cwvA:
undetectable		 1pxxA-5cwvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 9 VAL A1596
LEU A1597
LEU A1729
GLY A1647
ALA A1648
 None
 1.14A 1pxxB-5cwvA:
undetectable		 1pxxB-5cwvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 10 VAL A1596
LEU A1597
LEU A1729
GLY A1647
ALA A1648
 None
 1.14A 1pxxD-5cwvA:
undetectable		 1pxxD-5cwvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 12 ILE A1532
LEU A1535
VAL A1502
GLY A1592
ALA A1593
 None
 1.01A 1r9oA-5cwvA:
undetectable		 1r9oA-5cwvA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		4 / 8 ALA A1641
SER A1608
LEU A1543
VAL A1610
 None
 0.91A 2bxgA-5cwvA:
undetectable		 2bxgA-5cwvA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		3 / 3 GLN A1591
LYS A1594
VAL A1596
 None
 0.89A 2jfaB-5cwvA:
undetectable		 2jfaB-5cwvA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 12 VAL A1596
LEU A1597
LEU A1729
GLY A1647
ALA A1648
 None
 1.06A 3n8zB-5cwvA:
undetectable		 3n8zB-5cwvA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 12 LEU A1665
LEU A1671
VAL A1646
ALA A1643
LEU A1722
 None
 1.09A 3nt1A-5cwvA:
undetectable		 3nt1A-5cwvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 12 LEU A1665
LEU A1671
VAL A1646
ALA A1643
LEU A1722
 None
 1.08A 3nt1B-5cwvA:
1.9		 3nt1B-5cwvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 12 ILE A1479
ALA A1493
LEU A1497
LEU A1408
LEU A1403
 None
 1.02A 3ozuA-5cwvA:
undetectable		 3ozuA-5cwvA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 12 LEU A1665
LEU A1671
VAL A1646
ALA A1643
LEU A1722
 None
 1.09A 3pghD-5cwvA:
undetectable		 3pghD-5cwvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 12 LEU A1526
LEU A1475
GLY A1472
ILE A1468
ALA A1467
 None
 1.05A 3uwlB-5cwvA:
undetectable		 3uwlB-5cwvA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 12 LEU A1526
LEU A1475
GLY A1472
ILE A1468
ALA A1467
 None
 1.03A 3uwlD-5cwvA:
undetectable		 3uwlD-5cwvA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		4 / 6 THR A1731
GLY A1734
ILE A1658
LEU A1729
 None
 1.01A 4acbC-5cwvA:
undetectable		 4acbC-5cwvA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 12 VAL A1645
ALA A1641
MET A1495
LEU A1535
VAL A1534
 None
 1.18A 4eckA-5cwvA:
undetectable		 4eckA-5cwvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 12 ASN A1527
LEU A1586
CYH A1520
GLY A1472
ASP A1473
 None
 1.21A 4n09A-5cwvA:
undetectable		 4n09A-5cwvA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 10 GLU A1545
LEU A1584
VAL A1536
LEU A1535
MET A1495
 None
 1.35A 4r3aB-5cwvA:
undetectable		 4r3aB-5cwvA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		4 / 6 LEU A1632
LEU A1617
VAL A1618
ARG A1628
 None
 1.21A 4uswA-5cwvA:
undetectable		 4uswA-5cwvA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 12 ASP A1537
LEU A1583
LEU A1582
ILE A1523
GLY A1592
 None
 0.97A 4xi3B-5cwvA:
undetectable		 4xi3B-5cwvA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 12 VAL A1596
LEU A1597
LEU A1729
GLY A1647
ALA A1648
 None
 1.09A 5ikqA-5cwvA:
undetectable		 5ikqA-5cwvA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 12 VAL A1596
LEU A1597
LEU A1729
GLY A1647
ALA A1648
 None
 1.09A 5ikqB-5cwvA:
undetectable		 5ikqB-5cwvA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 12 LEU A1665
LEU A1671
VAL A1646
ALA A1643
LEU A1722
 None
 1.06A 5jvzA-5cwvA:
undetectable		 5jvzA-5cwvA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		4 / 8 TYR A1425
ALA A1410
ARG A1421
ASP A1481
 None
 1.06A 6hu9a-5cwvA:
undetectable
6hu9e-5cwvA:
1.1		 6hu9a-5cwvA:
21.59
6hu9e-5cwvA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		4 / 6 TYR A1425
ALA A1410
ARG A1421
ASP A1481
 None
 0.96A 6hu9m-5cwvA:
undetectable
6hu9q-5cwvA:
1.1		 6hu9m-5cwvA:
21.59
6hu9q-5cwvA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5cwv NUCLEOPORIN NUP192
(Chaetomium
thermophilum) 		5 / 12 LEU A1526
LEU A1475
GLY A1472
ILE A1468
ALA A1467
 None
 1.07A 6qxsD-5cwvA:
undetectable		 6qxsD-5cwvA:
20.90