SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cx8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		5 / 10 ALA A 150
PHE A 148
GLY A 152
LEU A 220
PRO A 221
 None
 1.32A 1cmcA-5cx8A:
undetectable
1cmcB-5cx8A:
undetectable		 1cmcA-5cx8A:
11.85
1cmcB-5cx8A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		5 / 9 LEU A 386
ILE A 387
LEU A 265
VAL A 260
ALA A 256
 None
 1.31A 1e7aA-5cx8A:
undetectable		 1e7aA-5cx8A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		3 / 3 ARG A 212
THR A 127
VAL A 124
 None
 0.61A 1hxbA-5cx8A:
undetectable		 1hxbA-5cx8A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		4 / 7 LEU A 408
GLU A 431
LEU A 432
GLU A 435
 None
 0.86A 1linA-5cx8A:
undetectable		 1linA-5cx8A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		5 / 12 ALA A 150
PHE A 148
GLY A 152
LEU A 220
PRO A 221
 None
 1.26A 1mj2A-5cx8A:
undetectable
1mj2B-5cx8A:
undetectable		 1mj2A-5cx8A:
11.64
1mj2B-5cx8A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		5 / 11 LEU A 220
PRO A 221
ALA A 150
PHE A 148
GLY A 152
 None
 1.33A 1mjqA-5cx8A:
undetectable
1mjqB-5cx8A:
undetectable		 1mjqA-5cx8A:
11.64
1mjqB-5cx8A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		5 / 10 LEU A 220
PRO A 221
ALA A 150
PHE A 148
GLY A 152
 None
 1.33A 1mjqC-5cx8A:
undetectable
1mjqD-5cx8A:
undetectable		 1mjqC-5cx8A:
11.64
1mjqD-5cx8A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		5 / 10 LEU A 220
PRO A 221
ALA A 150
PHE A 148
GLY A 152
 None
 1.31A 1mjqG-5cx8A:
undetectable
1mjqH-5cx8A:
undetectable		 1mjqG-5cx8A:
11.64
1mjqH-5cx8A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		5 / 11 LEU A 220
PRO A 221
ALA A 150
PHE A 148
GLY A 152
 None
 1.34A 1mjqI-5cx8A:
undetectable
1mjqJ-5cx8A:
undetectable		 1mjqI-5cx8A:
11.64
1mjqJ-5cx8A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		4 / 6 LEU A 408
GLU A 383
LEU A 432
LEU A 424
 None
 1.01A 1mt1D-5cx8A:
undetectable
1mt1E-5cx8A:
undetectable		 1mt1D-5cx8A:
11.85
1mt1E-5cx8A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		3 / 3 ARG A 212
ASN A 144
THR A 127
 None
 0.67A 2q63A-5cx8A:
undetectable		 2q63A-5cx8A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		3 / 3 ARG A 212
THR A 127
VAL A 124
 None
 0.43A 2q64A-5cx8A:
undetectable		 2q64A-5cx8A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		3 / 3 ARG A 212
THR A 127
VAL A 124
 None
 0.56A 2qakA-5cx8A:
undetectable		 2qakA-5cx8A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		4 / 8 ILE A 106
GLY A 105
LEU A  81
PHE A  84
 None
 0.83A 2vctA-5cx8A:
2.4		 2vctA-5cx8A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		4 / 8 ILE A 106
GLY A 105
LEU A  81
PHE A  84
 None
 0.80A 2vctB-5cx8A:
2.3		 2vctB-5cx8A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		4 / 8 ILE A 106
GLY A 105
LEU A  81
PHE A  84
 None
 0.79A 2vctC-5cx8A:
1.0		 2vctC-5cx8A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		4 / 7 ILE A 106
GLY A 105
LEU A  81
PHE A  84
 None
 0.74A 2vctD-5cx8A:
2.3		 2vctD-5cx8A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		4 / 6 TYR A 234
ALA A 235
LEU A 238
ALA A 157
 None
 0.54A 3b6hA-5cx8A:
0.6		 3b6hA-5cx8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		4 / 6 TYR A 234
ALA A 235
LEU A 238
ALA A 157
 None
 0.45A 3b6hB-5cx8A:
undetectable		 3b6hB-5cx8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		4 / 7 TYR A 109
LEU A  92
GLN A  67
VAL A 443
 None
 1.16A 3jwqC-5cx8A:
undetectable		 3jwqC-5cx8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		3 / 3 ASN A 284
ASP A 281
ARG A 162
 None
 0.90A 3k13A-5cx8A:
undetectable		 3k13A-5cx8A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		5 / 12 ALA A 252
ALA A 253
LEU A 388
LEU A 244
ALA A 240
 None
 1.05A 4k6iA-5cx8A:
undetectable		 4k6iA-5cx8A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		4 / 7 LEU A 408
GLU A 390
ILE A 288
VAL A 384
 None
 1.08A 5jh7C-5cx8A:
undetectable		 5jh7C-5cx8A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		5 / 11 ASP A  77
THR A  74
VAL A 322
VAL A 354
LEU A  66
 None
 1.44A 5jkwA-5cx8A:
undetectable		 5jkwA-5cx8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		4 / 8 TRP A 445
LEU A 330
THR A 429
TRP A 326
 None
 1.15A 6c71B-5cx8A:
undetectable		 6c71B-5cx8A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5cx8 LIPOPROTEIN RAGB
(Porphyromonas
gingivalis) 		4 / 6 TRP A 482
MET A 442
GLY A 476
ALA A 479
 None
 1.07A 6fosA-5cx8A:
2.4		 6fosA-5cx8A:
10.20