SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cxc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		4 / 7 VAL B 459
LEU B 468
LEU B 513
VAL B 499
 None
 0.94A 1jgsA-5cxcB:
undetectable		 1jgsA-5cxcB:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		4 / 5 ASP B 778
VAL B 459
SER B 790
ASP B 681
 None
 1.45A 1n2xB-5cxcB:
undetectable		 1n2xB-5cxcB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		4 / 8 PHE B 649
PHE B 680
SER B 595
ALA B 651
 None
 1.08A 1rqpC-5cxcB:
undetectable		 1rqpC-5cxcB:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		4 / 8 PHE B 649
PHE B 680
SER B 595
ALA B 651
 None
 1.10A 1rqpA-5cxcB:
undetectable		 1rqpA-5cxcB:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		6 / 12 ILE B 521
ALA B 514
ALA B 515
LEU B 493
LEU B 523
VAL B 587
 None
 1.35A 1xlsA-5cxcB:
undetectable		 1xlsA-5cxcB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		6 / 12 ILE B 521
ALA B 514
ALA B 515
LEU B 493
LEU B 523
VAL B 587
 None
 1.36A 1xlsB-5cxcB:
undetectable		 1xlsB-5cxcB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		6 / 12 ILE B 521
ALA B 514
ALA B 515
LEU B 493
LEU B 523
VAL B 587
 None
 1.36A 1xlsC-5cxcB:
undetectable		 1xlsC-5cxcB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		6 / 12 ILE B 521
ALA B 514
ALA B 515
LEU B 493
LEU B 523
VAL B 587
 None
 1.35A 1xlsD-5cxcB:
undetectable		 1xlsD-5cxcB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		4 / 6 HIS B 683
PHE B 725
GLY B 747
LYS B 748
 None
 1.44A 2i30A-5cxcB:
undetectable		 2i30A-5cxcB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		4 / 8 PHE B 649
PHE B 680
SER B 595
ALA B 651
 None
 1.08A 2v7uA-5cxcB:
undetectable		 2v7uA-5cxcB:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		4 / 5 GLN B 637
THR B 652
HIS B 701
LEU B 699
 None
 1.22A 2zj0A-5cxcB:
undetectable		 2zj0A-5cxcB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		5 / 12 ARG B 724
HIS B 528
ALA B 469
ILE B 461
ASP B 780
 None
 1.39A 3lcvB-5cxcB:
undetectable		 3lcvB-5cxcB:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		4 / 4 LYS B 696
GLN B 743
ILE B 779
LEU B 777
 None
 1.49A 3qt0A-5cxcB:
undetectable		 3qt0A-5cxcB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		5 / 12 VAL B 615
PRO B 628
PRO B 566
ILE B 585
VAL B 587
 None
 1.45A 4eb6B-5cxcB:
undetectable
4eb6C-5cxcB:
undetectable		 4eb6B-5cxcB:
22.29
4eb6C-5cxcB:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		4 / 5 SER B 790
GLY B 792
VAL B 770
ASP B 794
 None
 1.05A 4eohA-5cxcB:
undetectable		 4eohA-5cxcB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		5 / 11 LEU B 666
VAL B 650
ILE B 656
SER B 655
LEU B 689
 None
 1.25A 4lhmA-5cxcB:
undetectable		 4lhmA-5cxcB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		3 / 3 TRP B 596
ARG B 505
LEU B 583
 None
 0.88A 5dbyA-5cxcB:
undetectable		 5dbyA-5cxcB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		4 / 4 ALA B 639
PRO B 628
LEU B 624
HIS B 618
 None
 1.41A 5eskA-5cxcB:
undetectable		 5eskA-5cxcB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		5 / 9 ALA B 516
ASP B 520
ILE B 585
VAL B 606
ILE B 591
 None
 1.09A 5kr0A-5cxcB:
undetectable		 5kr0A-5cxcB:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		4 / 6 VAL B 789
TRP B 800
ALA B 797
THR B 796
 None
 0.97A 6cduB-5cxcB:
undetectable
6cduC-5cxcB:
undetectable		 6cduB-5cxcB:
22.45
6cduC-5cxcB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1
(Chaetomium
thermophilum) 		4 / 7 GLY B 775
SER B 741
GLY B 740
VAL B 770
 None
 0.54A 6ekzA-5cxcB:
undetectable		 6ekzA-5cxcB:
12.81