SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cxf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DEU_B_SALB306_1 (TRANSCRIPTIONAL REGULATOR SLYA)	5cxf	ENVELOPE GLYCOPROTEIN B (Human betaherpesvirus 5)	4 / 6	THR A 255 THR A 253 ILE A 332 THR A 270	None	0.83A	3deuB-5cxfA: undetectable	3deuB-5cxfA: 13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DZU_A_9CRA7223_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5cxf	ENVELOPE GLYCOPROTEIN B (Human betaherpesvirus 5)	5 / 12	ILE A 179 ILE A 305 PHE A 309 LEU A 213 VAL A 331	None	1.03A	3dzuA-5cxfA: undetectable	3dzuA-5cxfA: 20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IB4_A_ERMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562)	5cxf	ENVELOPE GLYCOPROTEIN B (Human betaherpesvirus 5)	5 / 12	VAL A 274 ALA A 257 PHE A 138 LEU A 321 VAL A 322	None	1.16A	4ib4A-5cxfA: undetectable	4ib4A-5cxfA: 21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M11_C_MXMC606_2 (PROSTAGLANDIN G/H SYNTHASE 2)	5cxf	ENVELOPE GLYCOPROTEIN B (Human betaherpesvirus 5)	3 / 3	LEU A 671 ARG A 672 MET A 683	None	0.79A	4m11C-5cxfA: undetectable	4m11C-5cxfA: 21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW0_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5)	5cxf	ENVELOPE GLYCOPROTEIN B (Human betaherpesvirus 5)	4 / 7	THR A 221 THR A 256 ALA A 257 THR A 270	None	0.87A	4qw0K-5cxfA: undetectable	4qw0K-5cxfA: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW0_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5)	5cxf	ENVELOPE GLYCOPROTEIN B (Human betaherpesvirus 5)	4 / 7	THR A 221 THR A 256 ALA A 257 THR A 270	None	0.87A	4qw0Y-5cxfA: undetectable	4qw0Y-5cxfA: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IQE_C_NMYC600_1 (BIFUNCTIONAL AAC/APH)	5cxf	ENVELOPE GLYCOPROTEIN B (Human betaherpesvirus 5)	5 / 12	SER A 377 ASP A 362 TYR A 364 SER A 419 GLU A 381	None	1.45A	5iqeC-5cxfA: undetectable	5iqeC-5cxfA: 19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGD_A_ACTA826_0 (GEPHYRIN)	5cxf	ENVELOPE GLYCOPROTEIN B (Human betaherpesvirus 5)	3 / 3	HIS A 319 ARG A 141 ILE A 305	None	0.79A	6fgdA-5cxfA: undetectable	6fgdA-5cxfA: 20.59

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3DEU_B_SALB306_1","TRANSCRIPTIONAL REGULATOR SLYA","5cxf","ENVELOPE GLYCOPROTEIN B","Human betaherpesvirus 5",4,"THR A 255;THR A 253;ILE A 332;THR A 270","None","0.83A","3deuB-5cxfA:undetectable","3deuB-5cxfA:13.18"],["3DZU_A_9CRA7223_1","RETINOIC ACID RECEPTOR RXR-ALPHA","5cxf","ENVELOPE GLYCOPROTEIN B","Human betaherpesvirus 5",5,"ILE A 179;ILE A 305;PHE A 309;LEU A 213;VAL A 331","None","1.03A","3dzuA-5cxfA:undetectable","3dzuA-5cxfA:20.03"],["4IB4_A_ERMA2001_1","CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562","5cxf","ENVELOPE GLYCOPROTEIN B","Human betaherpesvirus 5",5,"VAL A 274;ALA A 257;PHE A 138;LEU A 321;VAL A 322","None","1.16A","4ib4A-5cxfA:undetectable","4ib4A-5cxfA:21.72"],["4M11_C_MXMC606_2","PROSTAGLANDIN G\/H SYNTHASE 2","5cxf","ENVELOPE GLYCOPROTEIN B","Human betaherpesvirus 5",3,"LEU A 671;ARG A 672;MET A 683","None","0.79A","4m11C-5cxfA:undetectable","4m11C-5cxfA:21.61"],["4QW0_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5","5cxf","ENVELOPE GLYCOPROTEIN B","Human betaherpesvirus 5",4,"THR A 221;THR A 256;ALA A 257;THR A 270","None","0.87A","4qw0K-5cxfA:undetectable","4qw0K-5cxfA:16.67"],["4QW0_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5","5cxf","ENVELOPE GLYCOPROTEIN B","Human betaherpesvirus 5",4,"THR A 221;THR A 256;ALA A 257;THR A 270","None","0.87A","4qw0Y-5cxfA:undetectable","4qw0Y-5cxfA:16.67"],["5IQE_C_NMYC600_1","BIFUNCTIONAL AAC\/APH","5cxf","ENVELOPE GLYCOPROTEIN B","Human betaherpesvirus 5",5,"SER A 377;ASP A 362;TYR A 364;SER A 419;GLU A 381","None","1.45A","5iqeC-5cxfA:undetectable","5iqeC-5cxfA:19.97"],["6FGD_A_ACTA826_0","GEPHYRIN","5cxf","ENVELOPE GLYCOPROTEIN B","Human betaherpesvirus 5",3,"HIS A 319;ARG A 141;ILE A 305","None","0.79A","6fgdA-5cxfA:undetectable","6fgdA-5cxfA:20.59"]]