SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cxk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5cxk CARBONIC ANHYDRASE
(Vibrio
cholerae) 		4 / 8 CYH A  42
ASP A  44
HIS A  98
GLY A 103
 ZN  A 301 (-2.1A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
 0.92A 1ekjA-5cxkA:
20.2
1ekjB-5cxkA:
20.0		 1ekjA-5cxkA:
25.83
1ekjB-5cxkA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5cxk CARBONIC ANHYDRASE
(Vibrio
cholerae) 		5 / 8 CYH A  42
HIS A  98
CYH A 101
GLY A 102
GLY A 103
 ZN  A 301 (-2.1A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.0A)
None
None
 0.27A 1ekjA-5cxkA:
20.2
1ekjB-5cxkA:
20.0		 1ekjA-5cxkA:
25.83
1ekjB-5cxkA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 5cxk CARBONIC ANHYDRASE
(Vibrio
cholerae) 		4 / 8 CYH A  42
ASP A  44
HIS A  98
GLY A 103
 ZN  A 301 (-2.1A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
 0.94A 1ekjA-5cxkA:
20.2
1ekjB-5cxkA:
20.0		 1ekjA-5cxkA:
25.83
1ekjB-5cxkA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 5cxk CARBONIC ANHYDRASE
(Vibrio
cholerae) 		5 / 8 CYH A  42
VAL A  66
HIS A  98
CYH A 101
GLY A 102
 ZN  A 301 (-2.1A)
None
ZN  A 301 (-3.2A)
ZN  A 301 (-2.0A)
None
 0.27A 1ekjA-5cxkA:
20.2
1ekjB-5cxkA:
20.0		 1ekjA-5cxkA:
25.83
1ekjB-5cxkA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5cxk CARBONIC ANHYDRASE
(Vibrio
cholerae) 		4 / 7 CYH A  42
ASP A  44
HIS A  98
GLY A 103
 ZN  A 301 (-2.1A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
 0.88A 1ekjE-5cxkA:
20.4
1ekjF-5cxkA:
20.0		 1ekjE-5cxkA:
25.83
1ekjF-5cxkA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5cxk CARBONIC ANHYDRASE
(Vibrio
cholerae) 		4 / 7 CYH A  42
HIS A  98
GLY A 102
GLY A 103
 ZN  A 301 (-2.1A)
ZN  A 301 (-3.2A)
None
None
 0.18A 1ekjE-5cxkA:
20.4
1ekjF-5cxkA:
20.0		 1ekjE-5cxkA:
25.83
1ekjF-5cxkA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 5cxk CARBONIC ANHYDRASE
(Vibrio
cholerae) 		4 / 8 CYH A  42
VAL A  66
GLY A 102
GLY A 103
 ZN  A 301 (-2.1A)
None
None
None
 0.24A 1ekjE-5cxkA:
20.4
1ekjF-5cxkA:
20.0		 1ekjE-5cxkA:
25.83
1ekjF-5cxkA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5cxk CARBONIC ANHYDRASE
(Vibrio
cholerae) 		4 / 8 CYH A  42
ASP A  44
HIS A  98
GLY A 103
 ZN  A 301 (-2.1A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
 0.89A 1ekjG-5cxkA:
20.1
1ekjH-5cxkA:
20.7		 1ekjG-5cxkA:
25.83
1ekjH-5cxkA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5cxk CARBONIC ANHYDRASE
(Vibrio
cholerae) 		5 / 8 CYH A  42
HIS A  98
CYH A 101
GLY A 102
GLY A 103
 ZN  A 301 (-2.1A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.0A)
None
None
 0.21A 1ekjG-5cxkA:
20.1
1ekjH-5cxkA:
20.7		 1ekjG-5cxkA:
25.83
1ekjH-5cxkA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 5cxk CARBONIC ANHYDRASE
(Vibrio
cholerae) 		4 / 6 CYH A  42
VAL A  66
HIS A  98
CYH A 101
 ZN  A 301 (-2.1A)
None
ZN  A 301 (-3.2A)
ZN  A 301 (-2.0A)
 0.21A 1ekjG-5cxkA:
20.1
1ekjH-5cxkA:
20.7		 1ekjG-5cxkA:
25.83
1ekjH-5cxkA:
25.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 5cxk CARBONIC ANHYDRASE
(Vibrio
cholerae) 		5 / 10 CYH A  42
ASP A  44
HIS A  98
GLY A 103
ALA A 107
 ZN  A 301 (-2.1A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
 1.23A 3ucjA-5cxkA:
25.6		 3ucjA-5cxkA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 5cxk CARBONIC ANHYDRASE
(Vibrio
cholerae) 		5 / 10 CYH A  42
VAL A  66
HIS A  98
CYH A 101
ALA A 107
 ZN  A 301 (-2.1A)
None
ZN  A 301 (-3.2A)
ZN  A 301 (-2.0A)
None
 1.07A 3ucjA-5cxkA:
25.6		 3ucjA-5cxkA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 5cxk CARBONIC ANHYDRASE
(Vibrio
cholerae) 		6 / 10 CYH A  42
VAL A  66
HIS A  98
CYH A 101
GLY A 102
ALA A 106
 ZN  A 301 (-2.1A)
None
ZN  A 301 (-3.2A)
ZN  A 301 (-2.0A)
None
None
 0.37A 3ucjA-5cxkA:
25.6		 3ucjA-5cxkA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 5cxk CARBONIC ANHYDRASE
(Vibrio
cholerae) 		5 / 10 CYH A  42
VAL A  66
HIS A  98
CYH A 101
ALA A 107
 ZN  A 301 (-2.1A)
None
ZN  A 301 (-3.2A)
ZN  A 301 (-2.0A)
None
 1.06A 3ucjB-5cxkA:
26.2		 3ucjB-5cxkA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 5cxk CARBONIC ANHYDRASE
(Vibrio
cholerae) 		6 / 10 CYH A  42
VAL A  66
HIS A  98
CYH A 101
GLY A 102
ALA A 106
 ZN  A 301 (-2.1A)
None
ZN  A 301 (-3.2A)
ZN  A 301 (-2.0A)
None
None
 0.37A 3ucjB-5cxkA:
26.2		 3ucjB-5cxkA:
38.26