SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 5cxo EPOXIDE HYDROLASE
(Streptomyces
albus) 		5 / 12 ASN A  58
SER A  57
ARG A  52
ALA A  34
ILE A  36
 P6G  A 202 (-3.2A)
P6G  A 202 (-3.2A)
None
None
None
 1.36A 1s14B-5cxoA:
undetectable		 1s14B-5cxoA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5cxo EPOXIDE HYDROLASE
(Streptomyces
albus) 		5 / 12 MET A  87
ALA A  61
ASP A  38
SER A  57
ASN A  58
 P6G  A 202 (-3.1A)
None
P6G  A 202 (-3.8A)
P6G  A 202 (-3.2A)
P6G  A 202 (-3.2A)
 1.08A 2dcfA-5cxoA:
undetectable		 2dcfA-5cxoA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5cxo EPOXIDE HYDROLASE
(Streptomyces
albus) 		5 / 11 MET A  87
ALA A  61
ASP A  38
SER A  57
ASN A  58
 P6G  A 202 (-3.1A)
None
P6G  A 202 (-3.8A)
P6G  A 202 (-3.2A)
P6G  A 202 (-3.2A)
 1.08A 2zmaA-5cxoA:
undetectable		 2zmaA-5cxoA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5cxo EPOXIDE HYDROLASE
(Streptomyces
albus) 		5 / 12 MET A  87
ALA A  61
ASP A  38
SER A  57
ASN A  58
 P6G  A 202 (-3.1A)
None
P6G  A 202 (-3.8A)
P6G  A 202 (-3.2A)
P6G  A 202 (-3.2A)
 1.12A 3a65A-5cxoA:
undetectable		 3a65A-5cxoA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A66_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5cxo EPOXIDE HYDROLASE
(Streptomyces
albus) 		5 / 10 MET A  87
ALA A  61
ASP A  38
SER A  57
ASN A  58
 P6G  A 202 (-3.1A)
None
P6G  A 202 (-3.8A)
P6G  A 202 (-3.2A)
P6G  A 202 (-3.2A)
 1.11A 3a66A-5cxoA:
undetectable		 3a66A-5cxoA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 5cxo EPOXIDE HYDROLASE
(Streptomyces
albus) 		3 / 3 THR A 107
SER A  78
PHE A 120
 None
 0.87A 3d4sA-5cxoA:
undetectable		 3d4sA-5cxoA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 5cxo EPOXIDE HYDROLASE
(Streptomyces
albus) 		4 / 7 TYR A  54
ILE A  36
PHE A  30
PHE A 106
 P6G  A 202 (-4.9A)
None
None
None
 1.15A 3tvxB-5cxoA:
undetectable		 3tvxB-5cxoA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWP_A_ACAA503_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5cxo EPOXIDE HYDROLASE
(Streptomyces
albus) 		5 / 10 MET A  87
ALA A  61
ASP A  38
SER A  57
ASN A  58
 P6G  A 202 (-3.1A)
None
P6G  A 202 (-3.8A)
P6G  A 202 (-3.2A)
P6G  A 202 (-3.2A)
 1.11A 3vwpA-5cxoA:
undetectable		 3vwpA-5cxoA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5cxo EPOXIDE HYDROLASE
(Streptomyces
albus) 		5 / 12 MET A  87
ALA A  61
ASP A  38
SER A  57
ASN A  58
 P6G  A 202 (-3.1A)
None
P6G  A 202 (-3.8A)
P6G  A 202 (-3.2A)
P6G  A 202 (-3.2A)
 1.11A 3vwqA-5cxoA:
undetectable		 3vwqA-5cxoA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5cxo EPOXIDE HYDROLASE
(Streptomyces
albus) 		5 / 11 MET A  87
ALA A  61
ASP A  38
SER A  57
ASN A  58
 P6G  A 202 (-3.1A)
None
P6G  A 202 (-3.8A)
P6G  A 202 (-3.2A)
P6G  A 202 (-3.2A)
 1.13A 3vwrA-5cxoA:
undetectable		 3vwrA-5cxoA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5cxo EPOXIDE HYDROLASE
(Streptomyces
albus) 		4 / 7 ALA A  72
ASP A 115
GLY A 112
GLU A 111
 None
 0.96A 5bs8A-5cxoA:
undetectable
5bs8B-5cxoA:
undetectable
5bs8C-5cxoA:
undetectable		 5bs8A-5cxoA:
14.81
5bs8B-5cxoA:
20.16
5bs8C-5cxoA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5cxo EPOXIDE HYDROLASE
(Streptomyces
albus) 		4 / 7 ALA A  72
ASP A 115
GLY A 112
GLU A 111
 None
 0.95A 5btdA-5cxoA:
undetectable
5btdB-5cxoA:
undetectable
5btdC-5cxoA:
undetectable		 5btdA-5cxoA:
14.81
5btdB-5cxoA:
20.16
5btdC-5cxoA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5cxo EPOXIDE HYDROLASE
(Streptomyces
albus) 		4 / 7 ALA A  72
ASP A 115
GLY A 112
GLU A 111
 None
 0.95A 5btdA-5cxoA:
undetectable
5btdC-5cxoA:
undetectable
5btdD-5cxoA:
undetectable		 5btdA-5cxoA:
14.81
5btdC-5cxoA:
14.81
5btdD-5cxoA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5cxo EPOXIDE HYDROLASE
(Streptomyces
albus) 		4 / 7 ASP A 115
THR A 109
LEU A 108
VAL A 105
 None
 1.03A 5ov9A-5cxoA:
undetectable		 5ov9A-5cxoA:
14.17