SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cxp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 7 MET A 177
ALA A 219
TYR A 216
ALA A 198
None
1.07A 1k5qA-5cxpA:
undetectable
1k5qB-5cxpA:
undetectable
1k5qA-5cxpA:
19.18
1k5qB-5cxpA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 7 LEU A  44
TYR A 260
GLY A  19
TYR A  39
None
None
NA  A 604 ( 3.9A)
None
0.88A 1lweA-5cxpA:
2.2
1lweA-5cxpA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 5 ALA A 117
TYR A 118
ALA A 113
TYR A 115
None
1.00A 1xl6A-5cxpA:
undetectable
1xl6B-5cxpA:
undetectable
1xl6A-5cxpA:
20.15
1xl6B-5cxpA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
5 / 9 GLY A  43
ALA A  42
SER A 291
LEU A  44
LEU A 272
None
None
NA  A 601 (-4.3A)
None
None
1.36A 1y7iA-5cxpA:
undetectable
1y7iA-5cxpA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 5 TYR A 115
PRO A 109
THR A  99
SER A  92
None
1.39A 1ymxA-5cxpA:
undetectable
1ymxA-5cxpA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
5 / 12 LEU A 233
GLY A 271
ASP A 268
CYH A  27
ALA A  25
CL  A 615 ( 4.1A)
None
None
None
None
1.29A 2bm9B-5cxpA:
undetectable
2bm9B-5cxpA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 5 TRP A 263
GLY A 235
LYS A 283
LEU A 272
P6G  A 622 (-3.5A)
None
None
None
1.50A 2dqyA-5cxpA:
undetectable
2dqyA-5cxpA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2REZ_A_ACTA156_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 7 THR A 121
TRP A  57
TRP A  65
MET A  93
None
1.22A 2rezA-5cxpA:
undetectable
2rezA-5cxpA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
7 / 12 TRP A  87
ASN A 140
GLU A 141
HIS A 207
TYR A 209
GLU A 230
TRP A 263
P6G  A 622 (-4.0A)
P6G  A 622 (-3.3A)
NA  A 607 ( 2.1A)
None
P6G  A 622 ( 3.4A)
P6G  A 622 ( 2.7A)
P6G  A 622 (-3.5A)
0.55A 2v3dA-5cxpA:
34.6
2v3dA-5cxpA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
6 / 11 TRP A  87
ASN A 140
GLU A 141
TYR A 209
GLU A 230
TRP A 263
P6G  A 622 (-4.0A)
P6G  A 622 (-3.3A)
NA  A 607 ( 2.1A)
P6G  A 622 ( 3.4A)
P6G  A 622 ( 2.7A)
P6G  A 622 (-3.5A)
0.59A 2v3dB-5cxpA:
34.6
2v3dB-5cxpA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 4 ALA A 117
TYR A 118
ALA A 113
TYR A 115
None
1.02A 2wlkA-5cxpA:
undetectable
2wlkB-5cxpA:
undetectable
2wlkA-5cxpA:
20.15
2wlkB-5cxpA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 8 PHE A  20
GLY A  21
GLY A 297
MET A 252
None
0.89A 2y6rB-5cxpA:
undetectable
2y6rB-5cxpA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 7 ILE A 294
PHE A  20
MET A 252
THR A 253
None
0.92A 3ag4N-5cxpA:
undetectable
3ag4W-5cxpA:
undetectable
3ag4N-5cxpA:
22.05
3ag4W-5cxpA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
5 / 11 THR A 152
THR A  95
ALA A 145
GLY A 101
THR A 100
None
None
CL  A 608 ( 3.9A)
None
None
1.33A 3mg0H-5cxpA:
undetectable
3mg0I-5cxpA:
undetectable
3mg0H-5cxpA:
20.88
3mg0I-5cxpA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
5 / 12 THR A   7
ALA A   6
ALA A 303
VAL A  10
GLY A 371
None
0.84A 3mg0Y-5cxpA:
undetectable
3mg0Z-5cxpA:
undetectable
3mg0Y-5cxpA:
18.68
3mg0Z-5cxpA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 7 PHE A 158
MET A 187
ASP A 143
TYR A 115
None
0.94A 3p6hA-5cxpA:
undetectable
3p6hA-5cxpA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 8 PHE A  20
GLY A  21
GLY A 297
MET A 252
None
0.84A 3v3nB-5cxpA:
undetectable
3v3nB-5cxpA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 8 SER A 354
ALA A 326
SER A 381
THR A 383
None
0.46A 4iklA-5cxpA:
undetectable
4iklB-5cxpA:
undetectable
4iklA-5cxpA:
14.74
4iklB-5cxpA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
5 / 12 PRO A  89
LEU A 107
GLY A 205
PHE A 158
THR A 229
None
0.86A 4mubA-5cxpA:
undetectable
4mubA-5cxpA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
5 / 12 PRO A  89
LEU A 107
GLY A 206
PHE A 158
THR A 229
None
1.33A 4mubA-5cxpA:
undetectable
4mubA-5cxpA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
5 / 10 THR A   7
ALA A   6
ALA A 303
VAL A  10
GLY A 371
None
0.96A 4qvyK-5cxpA:
undetectable
4qvyL-5cxpA:
undetectable
4qvyK-5cxpA:
18.02
4qvyL-5cxpA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
5 / 10 THR A   7
ALA A   6
ALA A 303
VAL A  10
GLY A 371
None
0.96A 4qvyY-5cxpA:
undetectable
4qvyZ-5cxpA:
undetectable
4qvyY-5cxpA:
18.02
4qvyZ-5cxpA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
3 / 3 MET A 287
GLN A 329
TYR A 312
None
1.03A 4udcA-5cxpA:
undetectable
4udcA-5cxpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
3 / 3 ARG A  18
ASP A 225
TRP A 227
None
1.17A 4xdqA-5cxpA:
undetectable
4xdqA-5cxpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 8 TYR A 115
ILE A 203
SER A 202
PHE A 161
None
0.84A 5alcL-5cxpA:
undetectable
5alcL-5cxpA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 7 ILE A 294
PHE A  20
MET A 252
THR A 253
None
0.90A 5b3sN-5cxpA:
undetectable
5b3sW-5cxpA:
undetectable
5b3sN-5cxpA:
22.05
5b3sW-5cxpA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
5 / 11 THR A 152
THR A  95
ALA A 145
GLY A 101
THR A 100
None
None
CL  A 608 ( 3.9A)
None
None
1.33A 5bxnV-5cxpA:
undetectable
5bxnW-5cxpA:
undetectable
5bxnV-5cxpA:
21.19
5bxnW-5cxpA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
5 / 12 VAL A 261
ILE A 176
TYR A 216
MET A 257
ALA A 219
None
1.47A 5fctB-5cxpA:
undetectable
5fctB-5cxpA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 7 ILE A 294
PHE A  20
MET A 252
THR A 253
None
0.85A 5iy5N-5cxpA:
undetectable
5iy5W-5cxpA:
undetectable
5iy5N-5cxpA:
22.05
5iy5W-5cxpA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
5 / 9 THR A 280
THR A  37
ILE A 265
THR A  33
SER A  31
CL  A 617 (-4.8A)
None
None
P6G  A 624 (-3.2A)
P6G  A 624 (-3.4A)
0.96A 5muoA-5cxpA:
undetectable
5muoB-5cxpA:
undetectable
5muoC-5cxpA:
undetectable
5muoD-5cxpA:
undetectable
5muoE-5cxpA:
undetectable
5muoA-5cxpA:
12.98
5muoB-5cxpA:
12.98
5muoC-5cxpA:
12.98
5muoD-5cxpA:
12.98
5muoE-5cxpA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 7 VAL A 322
ILE A 324
VAL A 301
ALA A 315
None
0.74A 5osrA-5cxpA:
undetectable
5osrA-5cxpA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 7 PHE A 293
VAL A 323
ILE A 248
THR A 384
None
1.01A 5vkqA-5cxpA:
undetectable
5vkqD-5cxpA:
undetectable
5vkqA-5cxpA:
12.29
5vkqD-5cxpA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 5 MET A 252
TYR A 298
TYR A 316
GLY A 297
None
1.19A 5x7pA-5cxpA:
undetectable
5x7pA-5cxpA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 6 PRO A 238
GLY A 239
THR A 240
LYS A 246
None
0.86A 5xxiA-5cxpA:
undetectable
5xxiA-5cxpA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
3 / 3 TYR A  39
ASN A  71
LEU A  47
None
0.69A 6b58A-5cxpA:
undetectable
6b58A-5cxpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 7 SER A 137
HIS A 207
GLY A 206
ARG A  48
None
None
None
P6G  A 622 ( 4.8A)
1.07A 6btxA-5cxpA:
undetectable
6btxA-5cxpA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 5 GLN A 336
VAL A 334
PRO A 307
THR A 331
None
1.47A 6cduA-5cxpA:
undetectable
6cduB-5cxpA:
undetectable
6cduA-5cxpA:
22.89
6cduB-5cxpA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
4 / 5 GLN A 336
VAL A 334
PRO A 307
THR A 331
None
1.45A 6cduI-5cxpA:
undetectable
6cduJ-5cxpA:
undetectable
6cduI-5cxpA:
22.89
6cduJ-5cxpA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
3 / 3 LYS A 321
VAL A 386
ASP A 388
None
NA  A 605 (-4.6A)
None
0.55A 6fgdA-5cxpA:
undetectable
6fgdA-5cxpA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum)
5 / 10 TRP A 144
MET A 187
GLY A 206
LEU A 181
GLY A 182
P6G  A 622 (-4.1A)
None
None
None
None
1.45A 6hqbA-5cxpA:
undetectable
6hqbJ-5cxpA:
undetectable
6hqbA-5cxpA:
11.54
6hqbJ-5cxpA:
9.12