SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cy4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5cy4 OLIGORIBONUCLEASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  27
ILE A  49
ARG A  75
LEU A 117
ILE A  12
 None
 0.90A 1bsxA-5cy4A:
undetectable		 1bsxA-5cy4A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5cy4 OLIGORIBONUCLEASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  27
ILE A  49
ARG A  75
LEU A 117
ILE A  12
 None
 0.90A 1bsxB-5cy4A:
undetectable		 1bsxB-5cy4A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 5cy4 OLIGORIBONUCLEASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  27
ILE A  49
ARG A  75
LEU A 117
ILE A  12
 None
 0.94A 2h79A-5cy4A:
undetectable		 2h79A-5cy4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5cy4 OLIGORIBONUCLEASE
(Acinetobacter
baumannii) 		4 / 7 ILE A 165
LEU A 117
ASP A 113
GLY A 107
 None
None
CA  A 202 (-2.8A)
None
 0.98A 2qqcD-5cy4A:
undetectable
2qqcE-5cy4A:
undetectable		 2qqcD-5cy4A:
18.88
2qqcE-5cy4A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 5cy4 OLIGORIBONUCLEASE
(Acinetobacter
baumannii) 		5 / 11 ILE A  33
SER A 103
PHE A  93
VAL A  46
LEU A  47
 None
 1.15A 3a9eB-5cy4A:
undetectable		 3a9eB-5cy4A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5cy4 OLIGORIBONUCLEASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  27
ILE A  49
ARG A  75
LEU A 117
ILE A  12
 None
 0.94A 3gwsX-5cy4A:
undetectable		 3gwsX-5cy4A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 5cy4 OLIGORIBONUCLEASE
(Acinetobacter
baumannii) 		4 / 5 LEU A  91
GLN A 126
LEU A 124
GLU A 123
 None
 0.88A 3h5gA-5cy4A:
undetectable
3h5gB-5cy4A:
undetectable		 3h5gA-5cy4A:
7.69
3h5gB-5cy4A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5cy4 OLIGORIBONUCLEASE
(Acinetobacter
baumannii) 		4 / 8 ASN A  63
GLU A  15
LEU A  19
PHE A 116
 None
CA  A 201 (-3.2A)
None
None
 1.15A 3rqwC-5cy4A:
undetectable
3rqwD-5cy4A:
undetectable		 3rqwC-5cy4A:
18.69
3rqwD-5cy4A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5cy4 OLIGORIBONUCLEASE
(Acinetobacter
baumannii) 		4 / 8 GLU A  15
LEU A  19
PHE A 116
ASN A  63
 CA  A 201 (-3.2A)
None
None
None
 1.14A 3rqwF-5cy4A:
undetectable
3rqwJ-5cy4A:
undetectable		 3rqwF-5cy4A:
18.69
3rqwJ-5cy4A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 5cy4 OLIGORIBONUCLEASE
(Acinetobacter
baumannii) 		5 / 9 ASP A  60
THR A  17
ASN A  63
GLY A  18
ASP A  20
 None
 1.39A 3sfuA-5cy4A:
undetectable		 3sfuA-5cy4A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 5cy4 OLIGORIBONUCLEASE
(Acinetobacter
baumannii) 		5 / 9 ASP A  60
THR A  17
ASN A  63
GLY A  18
ASP A  20
 None
 1.39A 3sfuB-5cy4A:
undetectable		 3sfuB-5cy4A:
16.11