SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cya'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D4S_A_TIMA401_2 (BETA-2 ADRENERGIC RECEPTOR/T4-LYSOZYME CHIMERA)	5cya	TUBULIN-SPECIFIC CHAPERONE C (Saccharomyces cerevisiae)	3 / 3	THR A 160 SER A 138 PHE A 164	None	0.67A	3d4sA-5cyaA: undetectable	3d4sA-5cyaA: 21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_4_BEZ4801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	5cya	TUBULIN-SPECIFIC CHAPERONE C (Saccharomyces cerevisiae)	4 / 5	LEU A 190 PHE A 220 ILE A 212 ILE A 230	None	0.89A	5dzk4-5cyaA: undetectable 5dzkg-5cyaA: 1.7 5dzkm-5cyaA: 1.7 5dzkn-5cyaA: 1.6	5dzk4-5cyaA: 0.75 5dzkg-5cyaA: 21.94 5dzkm-5cyaA: 24.10 5dzkn-5cyaA: 24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_W_BEZW801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	5cya	TUBULIN-SPECIFIC CHAPERONE C (Saccharomyces cerevisiae)	4 / 5	PHE A 220 ILE A 212 ILE A 230 LEU A 190	None	0.85A	5dzkB-5cyaA: undetectable 5dzkI-5cyaA: 1.7 5dzkW-5cyaA: undetectable	5dzkB-5cyaA: 21.94 5dzkI-5cyaA: 24.10 5dzkW-5cyaA: 0.75

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3D4S_A_TIMA401_2","BETA-2 ADRENERGIC RECEPTOR\/T4-LYSOZYME CHIMERA","5cya","TUBULIN-SPECIFIC CHAPERONE C","Saccharomyces cerevisiae",3,"THR A 160;SER A 138;PHE A 164","None","0.67A","3d4sA-5cyaA:undetectable","3d4sA-5cyaA:21.38"],["5DZK_4_BEZ4801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1;ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","5cya","TUBULIN-SPECIFIC CHAPERONE C","Saccharomyces cerevisiae",4,"LEU A 190;PHE A 220;ILE A 212;ILE A 230","None","0.89A","5dzk4-5cyaA:undetectable;5dzkg-5cyaA:1.7;5dzkm-5cyaA:1.7;5dzkn-5cyaA:1.6","5dzk4-5cyaA:0.75;5dzkg-5cyaA:21.94;5dzkm-5cyaA:24.10;5dzkn-5cyaA:24.10"],["5DZK_W_BEZW801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1;ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","5cya","TUBULIN-SPECIFIC CHAPERONE C","Saccharomyces cerevisiae",4,"PHE A 220;ILE A 212;ILE A 230;LEU A 190","None","0.85A","5dzkB-5cyaA:undetectable;5dzkI-5cyaA:1.7;5dzkW-5cyaA:undetectable","5dzkB-5cyaA:21.94;5dzkI-5cyaA:24.10;5dzkW-5cyaA:0.75"]]