SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cyf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 7 THR A 239
ASN A 243
CYH A 242
ASN A 150
 None
 0.95A 1dssG-5cyfA:
undetectable		 1dssG-5cyfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 8 THR A 239
ASN A 243
CYH A 242
ASN A 150
 None
 0.99A 1dssR-5cyfA:
undetectable		 1dssR-5cyfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_A_ADNA1260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 ARG A 121
THR A 124
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
FLC  A 301 (-3.7A)
None
None
FLC  A 301 (-2.8A)
 0.31A 1jdvA-5cyfA:
23.5
1jdvD-5cyfA:
23.5		 1jdvA-5cyfA:
25.58
1jdvD-5cyfA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_B_ADNB2260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 ARG A 121
THR A 124
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
FLC  A 301 (-3.7A)
None
None
FLC  A 301 (-2.8A)
 0.31A 1jdvB-5cyfA:
23.6
1jdvC-5cyfA:
6.5		 1jdvB-5cyfA:
25.58
1jdvC-5cyfA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_D_ADND3260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 ARG A 121
THR A 124
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
FLC  A 301 (-3.7A)
None
None
FLC  A 301 (-2.8A)
 0.30A 1jdvA-5cyfA:
23.5
1jdvD-5cyfA:
23.5		 1jdvA-5cyfA:
25.58
1jdvD-5cyfA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 12 ARG A 121
THR A 124
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
FLC  A 301 (-3.7A)
None
None
FLC  A 301 (-2.8A)
 0.32A 1jdvE-5cyfA:
23.5
1jdvF-5cyfA:
24.1		 1jdvE-5cyfA:
25.58
1jdvF-5cyfA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 9 THR A 193
GLY A 235
GLY A 190
SER A 138
GLU A 232
 None
 0.96A 1jhoA-5cyfA:
2.2		 1jhoA-5cyfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 9 THR A 193
GLY A 235
GLY A 190
SER A 138
GLU A 232
 None
 0.99A 1jhrA-5cyfA:
undetectable		 1jhrA-5cyfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 9 THR A 193
GLY A 235
GLY A 190
SER A 138
GLU A 232
 None
 0.94A 1jhyA-5cyfA:
2.2		 1jhyA-5cyfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 9 THR A 193
GLY A 235
GLY A 190
SER A 138
GLU A 232
 None
 1.01A 1l4nA-5cyfA:
undetectable		 1l4nA-5cyfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 9 THR A 193
GLY A 235
GLY A 190
SER A 138
GLU A 232
 None
 1.01A 1l5mA-5cyfA:
undetectable		 1l5mA-5cyfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 11 ARG A 121
THR A 124
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
FLC  A 301 (-3.7A)
None
None
FLC  A 301 (-2.8A)
 0.33A 1odiA-5cyfA:
23.8		 1odiA-5cyfA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 11 ARG A 121
THR A 124
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
FLC  A 301 (-3.7A)
None
None
FLC  A 301 (-2.8A)
 0.36A 1odiB-5cyfA:
23.8		 1odiB-5cyfA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 11 ARG A 121
THR A 124
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
FLC  A 301 (-3.7A)
None
None
FLC  A 301 (-2.8A)
 0.26A 1odiC-5cyfA:
24.0		 1odiC-5cyfA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 11 ARG A 121
THR A 124
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
FLC  A 301 (-3.7A)
None
None
FLC  A 301 (-2.8A)
 0.33A 1odiD-5cyfA:
23.9		 1odiD-5cyfA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 11 ARG A 121
THR A 124
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
FLC  A 301 (-3.7A)
None
None
FLC  A 301 (-2.8A)
 0.28A 1odiE-5cyfA:
23.9		 1odiE-5cyfA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 11 ARG A 121
THR A 124
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
FLC  A 301 (-3.7A)
None
None
FLC  A 301 (-2.8A)
 0.26A 1odiF-5cyfA:
23.8		 1odiF-5cyfA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 ARG A 121
SER A 125
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
None
None
None
FLC  A 301 (-2.8A)
 1.48A 1pw7A-5cyfA:
24.5		 1pw7A-5cyfA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 6 ARG A 121
TYR A 198
ASN A 205
GLU A 232
 FLC  A 301 (-3.0A)
None
None
None
 1.32A 1rjdA-5cyfA:
undetectable		 1rjdA-5cyfA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 8 THR A 124
ARG A 203
MET A 233
VAL A 257
 FLC  A 301 (-3.7A)
None
None
None
 0.39A 1rxcB-5cyfA:
26.2		 1rxcB-5cyfA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 8 THR A 124
ARG A 203
MET A 233
VAL A 257
 FLC  A 301 (-3.7A)
None
None
None
 0.48A 1rxcE-5cyfA:
26.3		 1rxcE-5cyfA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 8 THR A 124
ARG A 203
MET A 233
VAL A 257
 FLC  A 301 (-3.7A)
None
None
None
 0.42A 1rxcI-5cyfA:
26.3		 1rxcI-5cyfA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 8 THR A 124
ARG A 203
MET A 233
VAL A 257
 FLC  A 301 (-3.7A)
None
None
None
 0.40A 1rxcK-5cyfA:
24.9		 1rxcK-5cyfA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 12 LEU A 146
ALA A 194
SER A 125
ARG A 203
CYH A 141
 None
 1.38A 1ya3B-5cyfA:
undetectable		 1ya3B-5cyfA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 ARG A 121
THR A 124
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
FLC  A 301 (-3.7A)
None
None
FLC  A 301 (-2.8A)
 0.33A 1z35A-5cyfA:
23.5		 1z35A-5cyfA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 9 ARG A 121
THR A 124
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
FLC  A 301 (-3.7A)
None
None
FLC  A 301 (-2.8A)
 0.37A 1z37A-5cyfA:
23.5		 1z37A-5cyfA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 8 GLY A 235
THR A 239
VAL A 165
ILE A 250
 None
 0.76A 2a1mB-5cyfA:
undetectable		 2a1mB-5cyfA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 11 ARG A 121
THR A 124
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
FLC  A 301 (-3.7A)
None
None
FLC  A 301 (-2.8A)
 0.34A 2ac7A-5cyfA:
22.6
2ac7B-5cyfA:
22.6		 2ac7A-5cyfA:
24.92
2ac7B-5cyfA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 11 ARG A 121
THR A 124
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
FLC  A 301 (-3.7A)
None
None
FLC  A 301 (-2.8A)
 0.35A 2ac7A-5cyfA:
22.6
2ac7B-5cyfA:
22.6		 2ac7A-5cyfA:
24.92
2ac7B-5cyfA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 11 SER A  74
TYR A  81
ALA A  72
GLY A  73
ALA A  76
 None
 1.50A 2xh9A-5cyfA:
undetectable		 2xh9A-5cyfA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 11 VAL A 252
ILE A  51
ILE A  86
LEU A 287
ILE A 120
 None
 0.99A 3clbA-5cyfA:
undetectable		 3clbA-5cyfA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 12 VAL A 252
ILE A  51
ILE A  86
LEU A 287
ILE A 120
 None
 0.95A 3clbC-5cyfA:
undetectable		 3clbC-5cyfA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 8 THR A 239
ASN A 243
CYH A 242
ASN A 150
 None
 0.97A 3dmtC-5cyfA:
2.1		 3dmtC-5cyfA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 VAL A 252
ILE A  51
ILE A  86
LEU A 287
ILE A 120
 None
 0.98A 3hbbA-5cyfA:
undetectable		 3hbbA-5cyfA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 11 VAL A 252
ILE A  51
ILE A  86
LEU A 287
ILE A 120
 None
 0.92A 3hbbC-5cyfA:
undetectable		 3hbbC-5cyfA:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 THR A 124
PHE A 197
ARG A 203
GLU A 232
MET A 233
 FLC  A 301 (-3.7A)
None
None
None
None
 0.38A 3kvrA-5cyfA:
41.2		 3kvrA-5cyfA:
38.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 THR A 124
PHE A 197
ARG A 203
GLU A 232
MET A 233
 FLC  A 301 (-3.7A)
None
None
None
None
 0.41A 3kvrB-5cyfA:
41.1		 3kvrB-5cyfA:
38.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 5 VAL A  44
PHE A  23
PHE A  20
PHE A  25
 None
 1.01A 3owxB-5cyfA:
2.9		 3owxB-5cyfA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 11 ARG A 121
THR A 124
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
FLC  A 301 (-3.7A)
None
None
FLC  A 301 (-2.8A)
 0.35A 3uawA-5cyfA:
23.5		 3uawA-5cyfA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 ARG A 121
THR A 124
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
FLC  A 301 (-3.7A)
None
None
FLC  A 301 (-2.8A)
 0.30A 3uayA-5cyfA:
23.9		 3uayA-5cyfA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 11 ARG A 121
GLU A 232
MET A 233
GLU A 234
VAL A 257
 FLC  A 301 (-3.0A)
None
None
FLC  A 301 (-2.8A)
None
 0.90A 4d9hA-5cyfA:
24.4		 4d9hA-5cyfA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 ARG A 121
ALA A 194
GLU A 232
MET A 233
GLU A 234
 FLC  A 301 (-3.0A)
None
None
None
FLC  A 301 (-2.8A)
 0.36A 4da7A-5cyfA:
24.3		 4da7A-5cyfA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 11 ARG A 121
GLU A 232
MET A 233
GLU A 234
VAL A 257
 FLC  A 301 (-3.0A)
None
None
FLC  A 301 (-2.8A)
None
 0.95A 4danA-5cyfA:
23.9		 4danA-5cyfA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 12 ARG A 121
GLU A 232
MET A 233
GLU A 234
VAL A 257
 FLC  A 301 (-3.0A)
None
None
FLC  A 301 (-2.8A)
None
 0.95A 4danA-5cyfA:
23.9
4danB-5cyfA:
23.8		 4danA-5cyfA:
26.32
4danB-5cyfA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 8 THR A 124
ARG A 203
MET A 233
VAL A 257
 FLC  A 301 (-3.7A)
None
None
None
 0.43A 4e1vA-5cyfA:
25.1		 4e1vA-5cyfA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 8 THR A 124
ARG A 203
MET A 233
VAL A 257
 FLC  A 301 (-3.7A)
None
None
None
 0.46A 4e1vC-5cyfA:
24.7		 4e1vC-5cyfA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 8 THR A 124
ARG A 203
MET A 233
VAL A 257
 FLC  A 301 (-3.7A)
None
None
None
 0.50A 4e1vD-5cyfA:
24.8		 4e1vD-5cyfA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 8 THR A 124
ARG A 203
MET A 233
VAL A 257
 FLC  A 301 (-3.7A)
None
None
None
 0.46A 4e1vE-5cyfA:
25.3		 4e1vE-5cyfA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 8 THR A 124
ARG A 203
MET A 233
VAL A 257
 FLC  A 301 (-3.7A)
None
None
None
 0.56A 4e1vG-5cyfA:
24.1		 4e1vG-5cyfA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 8 THR A 124
ARG A 203
MET A 233
VAL A 257
 FLC  A 301 (-3.7A)
None
None
None
 0.52A 4e1vH-5cyfA:
24.8		 4e1vH-5cyfA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 9 THR A 193
GLY A 235
GLY A 190
SER A 138
GLU A 232
 None
 1.00A 4kqiA-5cyfA:
undetectable		 4kqiA-5cyfA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 4 THR A 193
GLU A 232
THR A  98
HIS A  91
 None
None
None
FLC  A 301 (-4.3A)
 1.35A 4ydqA-5cyfA:
2.6		 4ydqA-5cyfA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 6 PHE A  41
LYS A  82
PHE A  30
ASP A  38
 None
 1.28A 5hesA-5cyfA:
undetectable		 5hesA-5cyfA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 5cyf PUTATIVE URIDINE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 9 LEU A 282
VAL A 252
PHE A  41
LEU A 118
ILE A 250
 None
 1.25A 6fdyU-5cyfA:
undetectable		 6fdyU-5cyfA:
22.15