SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 11 ALA A 149
LEU A 147
LEU A 155
HIS A 176
ALA A 192
None
1.11A 1h9zA-5cykA:
undetectable
1h9zA-5cykA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
3 / 3 VAL A 456
ALA A 457
HIS A 409
None
0.64A 1q23L-5cykA:
undetectable
1q23L-5cykA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 11 LEU A 343
SER A 363
LEU A 338
ALA A 316
THR A 301
None
1.19A 1tz8A-5cykA:
undetectable
1tz8B-5cykA:
undetectable
1tz8A-5cykA:
15.69
1tz8B-5cykA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 11 ASP A 410
HIS A 387
VAL A 405
SER A 475
VAL A 463
None
1.46A 1uofA-5cykA:
undetectable
1uofA-5cykA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
4 / 5 ILE A  49
SER A  75
ARG A  42
LEU A  46
None
1.07A 1y0xX-5cykA:
undetectable
1y0xX-5cykA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
6 / 9 LEU A 147
PHE A 185
LEU A 155
HIS A 176
LEU A 215
ALA A 192
None
1.42A 2bxeA-5cykA:
undetectable
2bxeA-5cykA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
6 / 12 LEU A 147
PHE A 185
LEU A 155
HIS A 176
LEU A 215
ALA A 192
None
1.44A 2bxqA-5cykA:
undetectable
2bxqA-5cykA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 10 HIS A 176
ALA A 182
ALA A 149
ALA A 183
SER A 193
None
0.98A 2r2vC-5cykA:
undetectable
2r2vF-5cykA:
undetectable
2r2vG-5cykA:
undetectable
2r2vC-5cykA:
5.87
2r2vF-5cykA:
5.87
2r2vG-5cykA:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 10 HIS A 296
ALA A 302
ALA A 243
ALA A 303
SER A 315
None
1.05A 2r2vC-5cykA:
undetectable
2r2vF-5cykA:
undetectable
2r2vG-5cykA:
undetectable
2r2vC-5cykA:
5.87
2r2vF-5cykA:
5.87
2r2vG-5cykA:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 THR A  22
VAL A  96
SER A 420
SER A 435
GLN A  94
None
1.19A 2x2iA-5cykA:
2.1
2x2iA-5cykA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 10 THR A  22
VAL A  96
SER A 420
SER A 435
GLN A  94
None
1.16A 2x2iD-5cykA:
undetectable
2x2iD-5cykA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
4 / 8 ILE A 100
SER A 403
ARG A 419
SER A  98
None
1.00A 2zw9B-5cykA:
7.9
2zw9B-5cykA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
4 / 8 LEU A 120
SER A 124
ALA A 137
ALA A 138
None
1.03A 3ax9B-5cykA:
undetectable
3ax9B-5cykA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 GLY A 433
GLY A 429
SER A 430
LEU A 431
HIS A 366
None
0.95A 3e23A-5cykA:
undetectable
3e23A-5cykA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
None
0.99A 3keeA-5cykA:
undetectable
3keeA-5cykA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
None
1.03A 3keeB-5cykA:
undetectable
3keeB-5cykA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
None
1.05A 3keeC-5cykA:
undetectable
3keeC-5cykA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
None
0.98A 3keeD-5cykA:
undetectable
3keeD-5cykA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 LEU A  26
ILE A  61
GLU A  23
ASP A 417
SER A 403
None
1.25A 3ko0A-5cykA:
undetectable
3ko0B-5cykA:
undetectable
3ko0C-5cykA:
undetectable
3ko0D-5cykA:
undetectable
3ko0A-5cykA:
10.91
3ko0B-5cykA:
10.91
3ko0C-5cykA:
10.91
3ko0D-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 11 ASP A 417
SER A 403
LEU A  26
ILE A  61
GLU A  23
None
1.29A 3ko0A-5cykA:
undetectable
3ko0B-5cykA:
undetectable
3ko0C-5cykA:
undetectable
3ko0D-5cykA:
undetectable
3ko0A-5cykA:
10.91
3ko0B-5cykA:
10.91
3ko0C-5cykA:
10.91
3ko0D-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 11 GLU A  23
ASP A  64
LEU A  26
ILE A  61
ASP A 417
None
1.22A 3ko0C-5cykA:
undetectable
3ko0D-5cykA:
undetectable
3ko0E-5cykA:
undetectable
3ko0F-5cykA:
undetectable
3ko0C-5cykA:
10.91
3ko0D-5cykA:
10.91
3ko0E-5cykA:
10.91
3ko0F-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 11 GLU A  23
LEU A  26
ILE A  61
ASP A 417
SER A 403
None
1.20A 3ko0C-5cykA:
undetectable
3ko0D-5cykA:
undetectable
3ko0E-5cykA:
undetectable
3ko0F-5cykA:
undetectable
3ko0C-5cykA:
10.91
3ko0D-5cykA:
10.91
3ko0E-5cykA:
10.91
3ko0F-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 11 ASP A 417
LEU A  26
ILE A  61
GLU A  23
ASP A  64
None
1.21A 3ko0C-5cykA:
undetectable
3ko0D-5cykA:
undetectable
3ko0E-5cykA:
undetectable
3ko0F-5cykA:
undetectable
3ko0C-5cykA:
10.91
3ko0D-5cykA:
10.91
3ko0E-5cykA:
10.91
3ko0F-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 11 ASP A 417
SER A 403
LEU A  26
ILE A  61
GLU A  23
None
1.19A 3ko0C-5cykA:
undetectable
3ko0D-5cykA:
undetectable
3ko0E-5cykA:
undetectable
3ko0F-5cykA:
undetectable
3ko0C-5cykA:
10.91
3ko0D-5cykA:
10.91
3ko0E-5cykA:
10.91
3ko0F-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 11 GLU A  23
LEU A  26
ILE A  61
ASP A 417
SER A 403
None
1.35A 3ko0E-5cykA:
undetectable
3ko0F-5cykA:
undetectable
3ko0G-5cykA:
undetectable
3ko0H-5cykA:
undetectable
3ko0E-5cykA:
10.91
3ko0F-5cykA:
10.91
3ko0G-5cykA:
10.91
3ko0H-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 GLU A  23
LEU A  26
ILE A  61
ASP A 417
SER A 403
None
1.29A 3ko0G-5cykA:
undetectable
3ko0H-5cykA:
undetectable
3ko0I-5cykA:
undetectable
3ko0J-5cykA:
undetectable
3ko0G-5cykA:
10.91
3ko0H-5cykA:
10.91
3ko0I-5cykA:
10.91
3ko0J-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 ASP A 417
SER A 403
LEU A  26
ILE A  61
GLU A  23
None
1.23A 3ko0G-5cykA:
undetectable
3ko0H-5cykA:
undetectable
3ko0I-5cykA:
undetectable
3ko0J-5cykA:
undetectable
3ko0G-5cykA:
10.91
3ko0H-5cykA:
10.91
3ko0I-5cykA:
10.91
3ko0J-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 GLU A  23
LEU A  26
ILE A  61
ASP A 417
SER A 403
None
1.20A 3ko0K-5cykA:
undetectable
3ko0L-5cykA:
undetectable
3ko0M-5cykA:
undetectable
3ko0N-5cykA:
undetectable
3ko0K-5cykA:
10.91
3ko0L-5cykA:
10.91
3ko0M-5cykA:
10.91
3ko0N-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 LEU A  26
ILE A  61
GLU A  23
ASP A  64
ASP A 417
None
1.22A 3ko0M-5cykA:
undetectable
3ko0N-5cykA:
undetectable
3ko0O-5cykA:
undetectable
3ko0P-5cykA:
undetectable
3ko0M-5cykA:
10.91
3ko0N-5cykA:
10.91
3ko0O-5cykA:
10.91
3ko0P-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 11 ASP A 417
SER A 403
GLU A  23
LEU A  26
ILE A  61
None
1.19A 3ko0K-5cykA:
undetectable
3ko0L-5cykA:
undetectable
3ko0M-5cykA:
undetectable
3ko0N-5cykA:
undetectable
3ko0K-5cykA:
10.91
3ko0L-5cykA:
10.91
3ko0M-5cykA:
10.91
3ko0N-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 11 LEU A  26
ILE A  61
GLU A  23
ASP A 417
SER A 403
None
1.20A 3ko0O-5cykA:
undetectable
3ko0P-5cykA:
undetectable
3ko0Q-5cykA:
undetectable
3ko0R-5cykA:
undetectable
3ko0O-5cykA:
10.91
3ko0P-5cykA:
10.91
3ko0Q-5cykA:
10.91
3ko0R-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 ASP A 417
GLU A  23
ASP A  64
LEU A  26
ILE A  61
None
1.20A 3ko0M-5cykA:
undetectable
3ko0N-5cykA:
undetectable
3ko0O-5cykA:
undetectable
3ko0P-5cykA:
undetectable
3ko0M-5cykA:
10.91
3ko0N-5cykA:
10.91
3ko0O-5cykA:
10.91
3ko0P-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 ASP A 417
SER A 403
GLU A  23
LEU A  26
ILE A  61
None
1.23A 3ko0M-5cykA:
undetectable
3ko0N-5cykA:
undetectable
3ko0O-5cykA:
undetectable
3ko0P-5cykA:
undetectable
3ko0M-5cykA:
10.91
3ko0N-5cykA:
10.91
3ko0O-5cykA:
10.91
3ko0P-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 10 ASP A 417
SER A 403
LEU A  26
ILE A  61
GLU A  23
None
1.28A 3ko0O-5cykA:
undetectable
3ko0P-5cykA:
undetectable
3ko0Q-5cykA:
undetectable
3ko0R-5cykA:
undetectable
3ko0O-5cykA:
10.91
3ko0P-5cykA:
10.91
3ko0Q-5cykA:
10.91
3ko0R-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 11 ASP A 417
SER A 403
GLU A  23
LEU A  26
ILE A  61
None
1.25A 3ko0Q-5cykA:
undetectable
3ko0R-5cykA:
undetectable
3ko0S-5cykA:
undetectable
3ko0T-5cykA:
undetectable
3ko0Q-5cykA:
10.91
3ko0R-5cykA:
10.91
3ko0S-5cykA:
10.91
3ko0T-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB800_0
(GLUTAMATE RECEPTOR 2)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 10 TYR A  95
PRO A  29
SER A  31
LEU A  56
SER A  54
None
1.49A 3lsfB-5cykA:
undetectable
3lsfE-5cykA:
undetectable
3lsfB-5cykA:
19.50
3lsfE-5cykA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
None
1.08A 3sudA-5cykA:
undetectable
3sudA-5cykA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
None
1.04A 3sueA-5cykA:
undetectable
3sueA-5cykA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
None
1.13A 3sueB-5cykA:
undetectable
3sueB-5cykA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
None
1.04A 3sueC-5cykA:
undetectable
3sueC-5cykA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
None
1.03A 3sufA-5cykA:
undetectable
3sufA-5cykA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
None
1.02A 3sufB-5cykA:
undetectable
3sufB-5cykA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 11 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
None
1.06A 3sufC-5cykA:
undetectable
3sufC-5cykA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
4 / 6 LEU A  93
ILE A  67
TYR A  79
VAL A  15
None
0.92A 4a9kA-5cykA:
undetectable
4a9kA-5cykA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 GLY A 433
GLY A 432
LEU A 431
ALA A 360
LEU A 338
None
0.90A 5c0oF-5cykA:
undetectable
5c0oF-5cykA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
4 / 5 TYR A 314
SER A 346
ALA A 347
THR A 349
None
1.17A 5n0tA-5cykA:
undetectable
5n0tA-5cykA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
5 / 12 LEU A 221
VAL A 200
ALA A 182
ALA A 194
GLY A 195
None
1.17A 5tzoB-5cykA:
undetectable
5tzoB-5cykA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum)
3 / 3 ASP A 232
SER A 465
SER A 393
None
0.78A 6mxtA-5cykA:
undetectable
6mxtA-5cykA:
19.82