SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cyr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		4 / 8 GLU B 176
PHE B 479
PHE B 478
HIS B 483
 None
 0.82A 1ax9A-5cyrB:
undetectable		 1ax9A-5cyrB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		4 / 5 THR B 553
GLU B 558
THR B 590
LEU B  30
 None
 1.22A 1d4fC-5cyrB:
undetectable		 1d4fC-5cyrB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 PHE B 479
PHE B 370
PHE B 512
GLY B 350
SER B 451
 None
 1.01A 1fe2A-5cyrB:
undetectable		 1fe2A-5cyrB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		4 / 5 THR B  82
LEU B  86
LYS B 426
TYR B 428
 None
 1.29A 1gtiF-5cyrB:
undetectable		 1gtiF-5cyrB:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 10 LEU B 569
LEU B 568
GLU B 577
ALA B 579
LEU B 532
 None
 1.32A 1ie4A-5cyrB:
undetectable
1ie4C-5cyrB:
undetectable		 1ie4A-5cyrB:
12.05
1ie4C-5cyrB:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 VAL B 293
SER B 297
PHE B 446
LEU B 436
ARG B 429
 None
 1.02A 1jffB-5cyrB:
undetectable		 1jffB-5cyrB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 LEU B 201
ALA B 291
LEU B 289
LEU B 236
VAL B 235
 None
 1.04A 2c12C-5cyrB:
undetectable		 2c12C-5cyrB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 VAL B 293
SER B 297
PHE B 446
LEU B 436
ARG B 429
 None
 1.02A 2hxfB-5cyrB:
undetectable		 2hxfB-5cyrB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 VAL B 293
SER B 297
PHE B 446
LEU B 436
ARG B 429
 None
 1.02A 2hxhB-5cyrB:
undetectable		 2hxhB-5cyrB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		3 / 3 ARG B 564
VAL B 595
THR B 590
 None
 0.71A 2nmzA-5cyrB:
undetectable		 2nmzA-5cyrB:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		4 / 5 PRO B 398
ALA B 400
ASP B 190
ASP B 196
 None
 1.13A 2nyuB-5cyrB:
undetectable		 2nyuB-5cyrB:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 VAL B 293
SER B 297
PHE B 446
LEU B 436
ARG B 429
 None
 1.02A 2p4nB-5cyrB:
undetectable		 2p4nB-5cyrB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 VAL B 293
SER B 297
PHE B 446
LEU B 436
ARG B 429
 None
 1.02A 2wbeB-5cyrB:
undetectable		 2wbeB-5cyrB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 LEU B 445
SER B 301
PHE B 187
ILE B 306
SER B 313
 None
 1.48A 2xpwA-5cyrB:
undetectable		 2xpwA-5cyrB:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 VAL B 293
SER B 297
PHE B 446
LEU B 436
ARG B 429
 None
 1.03A 3dcoB-5cyrB:
undetectable		 3dcoB-5cyrB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 MET B 583
VAL B 542
ALA B 131
GLU B 139
VAL B  64
 None
 1.13A 3dl9A-5cyrB:
undetectable		 3dl9A-5cyrB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 VAL B 293
SER B 297
PHE B 446
LEU B 436
ARG B 429
 None
 1.03A 3edlB-5cyrB:
undetectable		 3edlB-5cyrB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 VAL B 293
SER B 297
PHE B 446
LEU B 436
ARG B 429
 None
 1.01A 3iz0B-5cyrB:
undetectable		 3iz0B-5cyrB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		3 / 3 ARG B 564
VAL B 595
THR B 590
 None
 0.67A 3k4vD-5cyrB:
undetectable		 3k4vD-5cyrB:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 11 VAL B 389
GLY B 302
ALA B 303
SER B 299
LEU B 194
 None
 1.17A 3n8yA-5cyrB:
undetectable		 3n8yA-5cyrB:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		4 / 7 ASP B 241
ILE B  97
VAL B 104
TYR B 220
 None
 1.00A 3p6hA-5cyrB:
undetectable		 3p6hA-5cyrB:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 TYR B  92
ALA B 261
HIS B 288
PHE B 259
SER B 418
 None
 1.39A 3pfgA-5cyrB:
undetectable		 3pfgA-5cyrB:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		6 / 9 ASP B 374
THR B 444
TYR B 349
GLY B 350
ASP B 351
ASP B 352
 None
SO4  B 702 (-3.4A)
None
None
ATP  B 701 (-2.4A)
ATP  B 701 (-3.5A)
 0.78A 3sfuA-5cyrB:
16.0		 3sfuA-5cyrB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 9 THR B 443
THR B 444
TYR B 349
GLY B 350
ASP B 352
 SO4  B 702 (-4.4A)
SO4  B 702 (-3.4A)
None
None
ATP  B 701 (-3.5A)
 0.99A 3sfuA-5cyrB:
16.0		 3sfuA-5cyrB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		7 / 9 ASP B 374
THR B 444
TYR B 349
GLY B 350
ASP B 351
ASP B 352
LEU B 513
 None
SO4  B 702 (-3.4A)
None
None
ATP  B 701 (-2.4A)
ATP  B 701 (-3.5A)
None
 0.77A 3sfuB-5cyrB:
8.9		 3sfuB-5cyrB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 9 THR B 448
TYR B 349
ASP B 351
ASP B 352
LEU B 513
 None
None
ATP  B 701 (-2.4A)
ATP  B 701 (-3.5A)
None
 1.41A 3sfuB-5cyrB:
8.9		 3sfuB-5cyrB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 11 ARG B 280
ASP B 374
LEU B 436
THR B 444
ASP B 351
 ATP  B 701 (-2.8A)
None
None
SO4  B 702 (-3.4A)
ATP  B 701 (-2.4A)
 1.23A 3sfuC-5cyrB:
15.8		 3sfuC-5cyrB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 11 ARG B 280
ASP B 374
THR B 444
GLY B 350
ASP B 351
 ATP  B 701 (-2.8A)
None
SO4  B 702 (-3.4A)
None
ATP  B 701 (-2.4A)
 1.19A 3sfuC-5cyrB:
15.8		 3sfuC-5cyrB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		3 / 3 PHE B 464
SER B 466
GLN B 461
 None
 0.79A 3smtA-5cyrB:
undetectable		 3smtA-5cyrB:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		4 / 4 ASP B 351
ASP B 447
GLY B 375
THR B 381
 ATP  B 701 (-2.4A)
None
None
None
 1.34A 3tl9B-5cyrB:
undetectable		 3tl9B-5cyrB:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		4 / 8 LEU B 149
THR B 543
VAL B 542
LEU B 132
 None
 0.64A 3uniB-5cyrB:
undetectable		 3uniB-5cyrB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		4 / 7 ARG B 145
VAL B 542
PHE B 136
GLU B 139
 None
 1.23A 4jseA-5cyrB:
0.0
4jseB-5cyrB:
undetectable		 4jseA-5cyrB:
19.81
4jseB-5cyrB:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		4 / 7 PHE B 136
GLU B 139
ARG B 145
VAL B 542
 None
 1.26A 4jseA-5cyrB:
0.0
4jseB-5cyrB:
undetectable		 4jseA-5cyrB:
19.81
4jseB-5cyrB:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 PRO B 629
PHE B 620
LEU B 569
VAL B 634
GLY B 324
 None
 1.28A 4mubA-5cyrB:
undetectable		 4mubA-5cyrB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 PRO B 629
PHE B 620
LEU B 569
VAL B 634
GLY B 325
 None
 1.28A 4mubA-5cyrB:
undetectable		 4mubA-5cyrB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		4 / 6 TYR B 638
ASP B 576
VAL B 586
ALA B 585
 None
 1.13A 4nkvC-5cyrB:
undetectable		 4nkvC-5cyrB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 VAL B 389
GLY B 302
ALA B 303
SER B 299
LEU B 194
 None
 1.16A 4rrwA-5cyrB:
undetectable		 4rrwA-5cyrB:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 VAL B 389
GLY B 302
ALA B 303
SER B 299
LEU B 194
 None
 1.16A 4rrwB-5cyrB:
undetectable		 4rrwB-5cyrB:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 VAL B 389
GLY B 302
ALA B 303
SER B 299
LEU B 194
 None
 1.16A 4rrzA-5cyrB:
undetectable		 4rrzA-5cyrB:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 VAL B 389
GLY B 302
ALA B 303
SER B 299
LEU B 194
 None
 1.16A 4rrzB-5cyrB:
undetectable		 4rrzB-5cyrB:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 LEU B 517
LEU B 513
LEU B 329
MET B 307
ALA B 347
 None
 0.99A 4x1yB-5cyrB:
undetectable		 4x1yB-5cyrB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 11 LEU B 517
LEU B 513
LEU B 329
MET B 307
ALA B 347
 None
 1.18A 4x20D-5cyrB:
undetectable		 4x20D-5cyrB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		3 / 3 GLU B 262
THR B 109
HIS B 110
 None
 0.82A 4ydqB-5cyrB:
undetectable		 4ydqB-5cyrB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		3 / 3 TRP B 158
ARG B 120
LEU B 165
 None
 0.91A 5dbyA-5cyrB:
0.0		 5dbyA-5cyrB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 LEU B 194
LEU B 183
ILE B 306
PHE B 300
VAL B 394
 None
 1.19A 5dlvB-5cyrB:
undetectable		 5dlvB-5cyrB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 VAL B 293
SER B 297
PHE B 446
LEU B 436
ARG B 429
 None
 1.04A 5hnwB-5cyrB:
undetectable		 5hnwB-5cyrB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 VAL B 293
SER B 297
PHE B 446
LEU B 436
ARG B 429
 None
 1.05A 5hnxB-5cyrB:
undetectable		 5hnxB-5cyrB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 VAL B 293
SER B 297
PHE B 446
LEU B 436
ARG B 429
 None
 1.05A 5hnyB-5cyrB:
undetectable		 5hnyB-5cyrB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 VAL B 389
GLY B 302
ALA B 303
SER B 299
LEU B 194
 None
 1.17A 5ikrA-5cyrB:
undetectable		 5ikrA-5cyrB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 LEU B 517
LEU B 513
LEU B 329
MET B 307
ALA B 347
 None
 1.10A 5itzB-5cyrB:
undetectable		 5itzB-5cyrB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		4 / 6 PHE B 283
THR B 438
TYR B 282
TYR B 270
 None
None
PO4  B 703 (-4.1A)
None
 0.95A 5lrbA-5cyrB:
undetectable		 5lrbA-5cyrB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		5 / 12 LEU B 517
LEU B 513
LEU B 329
MET B 307
ALA B 347
 None
 1.03A 5mioB-5cyrB:
undetectable		 5mioB-5cyrB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		3 / 3 HIS B  99
HIS B 102
ARG B 222
 None
 0.70A 6b58A-5cyrB:
undetectable		 6b58A-5cyrB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		3 / 3 ARG B  27
ARG B 566
ARG B 648
 None
 1.09A 6bplA-5cyrB:
undetectable
6bplB-5cyrB:
undetectable		 6bplA-5cyrB:
9.02
6bplB-5cyrB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		4 / 6 ARG B  42
PRO B  46
GLN B  47
ILE B 587
 None
 1.49A 6ef6A-5cyrB:
undetectable		 6ef6A-5cyrB:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5cyr RNA-DEPENDENT RNA
POLYMERASE
(Thosea
asigna
virus) 		4 / 5 TYR B 270
VAL B  64
PHE B 122
GLY B 160
 None
 1.25A 6hd4A-5cyrB:
undetectable		 6hd4A-5cyrB:
8.37