SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cyu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5cyu CONSERVED MEMBRANE
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 225
THR A 294
ARG A 213
LEU A 330
LEU A 199
 None
 1.17A 1eiiA-5cyuA:
undetectable		 1eiiA-5cyuA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 5cyu CONSERVED MEMBRANE
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 458
LEU A 106
LEU A 431
ILE A 422
ALA A 423
 None
 0.98A 1ha2A-5cyuA:
undetectable		 1ha2A-5cyuA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 5cyu CONSERVED MEMBRANE
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY A 421
ILE A 422
PRO A 137
ILE A 133
 None
 0.75A 1n49A-5cyuA:
undetectable		 1n49A-5cyuA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 5cyu CONSERVED MEMBRANE
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY A 366
ILE A 364
VAL A 180
PRO A 370
 None
 1.07A 1rxcD-5cyuA:
undetectable		 1rxcD-5cyuA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 5cyu CONSERVED MEMBRANE
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY A 366
ILE A 364
VAL A 180
PRO A 370
 None
 1.07A 1rxcL-5cyuA:
undetectable		 1rxcL-5cyuA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5cyu CONSERVED MEMBRANE
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A 367
ARG A 368
ILE A 364
 None
 0.68A 1uobA-5cyuA:
undetectable		 1uobA-5cyuA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5cyu CONSERVED MEMBRANE
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 VAL A 389
ILE A 413
ILE A 169
LEU A 170
 None
 0.79A 3hegA-5cyuA:
undetectable		 3hegA-5cyuA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5cyu CONSERVED MEMBRANE
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASN A 100
THR A 102
LEU A 106
ALA A 458
 None
 0.88A 3kp6A-5cyuA:
undetectable		 3kp6A-5cyuA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5cyu CONSERVED MEMBRANE
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 371
ARG A 368
ILE A 364
PRO A 182
LEU A 170
 None
 1.21A 3nrrA-5cyuA:
undetectable		 3nrrA-5cyuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 5cyu CONSERVED MEMBRANE
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY A 366
ILE A 364
VAL A 180
PRO A 370
 None
 1.06A 4e1vB-5cyuA:
undetectable		 4e1vB-5cyuA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5cyu CONSERVED MEMBRANE
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 THR A 361
GLN A 442
THR A 201
HIS A 206
 None
 1.31A 4pfjB-5cyuA:
undetectable		 4pfjB-5cyuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5cyu CONSERVED MEMBRANE
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ALA A 427
ASN A 430
LEU A 431
 None
 0.28A 5i1nB-5cyuA:
undetectable		 5i1nB-5cyuA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5cyu CONSERVED MEMBRANE
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ILE A 249
LEU A 264
HIS A 280
VAL A 291
 None
 0.96A 5jmnB-5cyuA:
undetectable		 5jmnB-5cyuA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5cyu CONSERVED MEMBRANE
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 4 GLU A 166
THR A 154
THR A 150
LEU A 371
 None
 1.35A 5v96A-5cyuA:
undetectable		 5v96A-5cyuA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5cyu CONSERVED MEMBRANE
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 4 GLU A 166
THR A 154
THR A 150
LEU A 371
 None
 1.38A 5v96B-5cyuA:
undetectable		 5v96B-5cyuA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5cyu CONSERVED MEMBRANE
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 4 GLU A 166
THR A 154
THR A 150
LEU A 371
 None
 1.37A 5v96D-5cyuA:
undetectable		 5v96D-5cyuA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5cyu CONSERVED MEMBRANE
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE A 169
ILE A 176
ALA A 175
LEU A 371
ALA A 375
 None
 1.36A 5zjiB-5cyuA:
undetectable		 5zjiB-5cyuA:
10.24