SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cyx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5cyx PROTEIN CDHR2
(Mus
musculus) 		5 / 12 ASP A  18
LEU A  19
ARG A  97
SER A  63
ALA A  23
 None
 1.07A 2ejtA-5cyxA:
undetectable		 2ejtA-5cyxA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 5cyx PROTEIN CDHR2
(Mus
musculus) 		5 / 12 ALA A 234
ARG A 322
ILE A 321
SER A 239
VAL A 240
 None
 1.00A 4ax8A-5cyxA:
undetectable		 4ax8A-5cyxA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5cyx PROTEIN CDHR2
(Mus
musculus) 		4 / 7 ASP A  66
ASP A  99
ASN A 100
GLU A  17
 CA  A1001 (-3.2A)
CA  A1001 ( 2.6A)
CA  A1001 (-4.8A)
CA  A1001 ( 2.8A)
 1.09A 4feuB-5cyxA:
undetectable		 4feuB-5cyxA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 5cyx PROTEIN CDHR2
(Mus
musculus) 		5 / 10 ALA A 228
ILE A 277
VAL A 319
VAL A 279
VAL A 240
 None
 0.78A 4j5jB-5cyxA:
undetectable		 4j5jB-5cyxA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5cyx PROTEIN CDHR2
(Mus
musculus) 		5 / 12 GLY A 137
ASP A 130
ILE A 101
ASN A 100
SER A 202
 CA  A1003 ( 4.7A)
CA  A1003 (-2.1A)
None
CA  A1001 (-4.8A)
None
 1.08A 4rtsA-5cyxA:
undetectable		 4rtsA-5cyxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5cyx PROTEIN CDHR2
(Mus
musculus) 		4 / 5 GLY A 191
THR A 199
GLN A 140
THR A 135
 None
 1.25A 5h5fA-5cyxA:
undetectable		 5h5fA-5cyxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5cyx PROTEIN CDHR2
(Mus
musculus) 		5 / 7 PHE A 157
ILE A 143
PHE A 104
LEU A 184
ILE A 113
 None
 1.49A 6b5vA-5cyxA:
undetectable
6b5vC-5cyxA:
undetectable		 6b5vA-5cyxA:
12.16
6b5vC-5cyxA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5cyx PROTEIN CDHR2
(Mus
musculus) 		5 / 7 PHE A 157
ILE A 143
PHE A 104
LEU A 184
ILE A 113
 None
 1.49A 6b5vC-5cyxA:
undetectable
6b5vD-5cyxA:
undetectable		 6b5vC-5cyxA:
12.16
6b5vD-5cyxA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5cyx PROTEIN CDHR2
(Mus
musculus) 		5 / 7 PHE A 157
ILE A 143
PHE A 104
LEU A 184
ILE A 113
 None
 1.50A 6b5vB-5cyxA:
undetectable
6b5vD-5cyxA:
undetectable		 6b5vB-5cyxA:
12.16
6b5vD-5cyxA:
12.16