SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5czc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 12 SER A 279
VAL A 276
GLY A 250
VAL A 112
MET A 262
 None
 1.46A 1a27A-5czcA:
undetectable		 1a27A-5czcA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		4 / 5 LEU A 280
VAL A 288
CYH A 289
ALA A 312
 None
 1.13A 1mz9D-5czcA:
undetectable		 1mz9D-5czcA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		4 / 4 LEU A 280
VAL A 288
CYH A 289
ALA A 312
 None
 1.26A 1mz9E-5czcA:
undetectable		 1mz9E-5czcA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		4 / 7 PHE A 237
MET A 127
THR A 128
LEU A 131
 None
 1.09A 2eikA-5czcA:
0.9
2eikJ-5czcA:
undetectable		 2eikA-5czcA:
20.00
2eikJ-5czcA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		4 / 7 ARG A 199
GLU A 197
ALA A 154
PRO A 207
 None
 0.89A 2ejfA-5czcA:
undetectable		 2ejfA-5czcA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 11 VAL A 290
GLY A 298
ASP A 294
ILE A 179
THR A 302
 None
 1.25A 2f9wA-5czcA:
undetectable
2f9wB-5czcA:
undetectable		 2f9wA-5czcA:
23.93
2f9wB-5czcA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 11 VAL A 290
GLY A 298
ASP A 294
ILE A 179
THR A 302
 None
 1.22A 3bexC-5czcA:
undetectable
3bexD-5czcA:
undetectable		 3bexC-5czcA:
22.44
3bexD-5czcA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 10 THR A 302
VAL A 290
GLY A 298
ASP A 294
ILE A 179
 None
 1.22A 3bexC-5czcA:
undetectable
3bexD-5czcA:
undetectable		 3bexC-5czcA:
22.44
3bexD-5czcA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 10 VAL A 290
GLY A 298
ASP A 294
ILE A 179
THR A 302
 None
 1.22A 3bexE-5czcA:
undetectable
3bexF-5czcA:
undetectable		 3bexE-5czcA:
22.44
3bexF-5czcA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 11 THR A 302
VAL A 290
GLY A 298
ASP A 294
ILE A 179
 None
 1.22A 3bexE-5czcA:
undetectable
3bexF-5czcA:
undetectable		 3bexE-5czcA:
22.44
3bexF-5czcA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 11 VAL A 290
GLY A 298
ASP A 294
ILE A 179
THR A 302
 None
 1.23A 3bf1A-5czcA:
undetectable
3bf1B-5czcA:
undetectable		 3bf1A-5czcA:
22.44
3bf1B-5czcA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 12 THR A 302
VAL A 290
GLY A 298
ASP A 294
ILE A 179
 None
 1.25A 3bf1A-5czcA:
undetectable
3bf1B-5czcA:
undetectable		 3bf1A-5czcA:
22.44
3bf1B-5czcA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 11 VAL A 290
GLY A 298
ASP A 294
ILE A 179
THR A 302
 None
 1.25A 3bf1C-5czcA:
undetectable
3bf1D-5czcA:
undetectable		 3bf1C-5czcA:
22.44
3bf1D-5czcA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 11 VAL A 290
GLY A 298
ASP A 294
ILE A 179
THR A 302
 None
 1.23A 3bf1E-5czcA:
undetectable
3bf1F-5czcA:
undetectable		 3bf1E-5czcA:
22.44
3bf1F-5czcA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 10 ALA A 113
VAL A  85
ALA A 129
ILE A  78
PHE A 121
 None
 1.22A 3fl9F-5czcA:
undetectable		 3fl9F-5czcA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 11 SER A 266
VAL A 259
LEU A 263
ALA A 113
VAL A 244
 None
 1.14A 4e0fA-5czcA:
undetectable		 4e0fA-5czcA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		3 / 3 PHE A  80
TYR A 209
TYR A  72
 None
None
GOL  A 401 ( 4.2A)
 1.10A 4ffwA-5czcA:
undetectable		 4ffwA-5czcA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 11 GLY A 108
ALA A 105
ASP A 247
ILE A 101
THR A 303
 None
 1.12A 4l1aA-5czcA:
undetectable		 4l1aA-5czcA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		3 / 3 ARG A 199
TRP A 195
ILE A 162
 None
 1.00A 4mwxA-5czcA:
undetectable		 4mwxA-5czcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 12 VAL A 290
GLY A 298
ASP A 294
ILE A 179
THR A 302
 None
 1.28A 4o5fA-5czcA:
undetectable
4o5fB-5czcA:
undetectable		 4o5fA-5czcA:
24.70
4o5fB-5czcA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 12 THR A 302
VAL A 290
GLY A 298
ASP A 294
ILE A 179
 None
 1.26A 4o5fA-5czcA:
undetectable
4o5fB-5czcA:
undetectable		 4o5fA-5czcA:
24.70
4o5fB-5czcA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		3 / 3 ILE A  78
ASP A  54
ARG A 133
 None
 0.78A 4pstA-5czcA:
undetectable		 4pstA-5czcA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 12 VAL A 290
GLY A 298
ASP A 294
ILE A 179
THR A 302
 None
 1.29A 5b8hA-5czcA:
undetectable
5b8hB-5czcA:
undetectable		 5b8hA-5czcA:
23.81
5b8hB-5czcA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 12 THR A 302
VAL A 290
GLY A 298
ASP A 294
ILE A 179
 None
 1.23A 5b8hA-5czcA:
undetectable
5b8hB-5czcA:
undetectable		 5b8hA-5czcA:
23.81
5b8hB-5czcA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		3 / 3 TRP A 195
ARG A 199
LEU A 186
 None
 0.92A 5dbyA-5czcA:
1.0		 5dbyA-5czcA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		4 / 8 ILE A  78
GLY A 130
LEU A 235
LEU A 119
 None
 0.86A 5hs1A-5czcA:
undetectable		 5hs1A-5czcA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		4 / 6 THR A 255
GLY A 256
GLU A 258
ILE A 232
 None
 0.93A 5kmfA-5czcA:
undetectable
5kmfC-5czcA:
undetectable		 5kmfA-5czcA:
21.71
5kmfC-5czcA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 11 VAL A 276
GLY A 250
ALA A 103
SER A 279
LEU A 280
 None
 1.17A 5x6yA-5czcA:
undetectable		 5x6yA-5czcA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE
(Streptomyces
halstedii) 		5 / 10 VAL A 276
GLY A 250
ALA A 103
SER A 279
LEU A 280
 None
 1.17A 5x6yB-5czcA:
undetectable		 5x6yB-5czcA:
18.51