SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5czr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		5 / 12 ASP A  18
LEU A  19
ARG A  97
SER A  63
ALA A  23
 None
 1.15A 2ejtA-5czrA:
undetectable		 2ejtA-5czrA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		5 / 11 PHE A  50
ILE A  77
SER A  43
PHE A  26
LEU A  19
 None
 1.30A 3a9eB-5czrA:
undetectable		 3a9eB-5czrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		5 / 12 ALA A  62
MET A  42
VAL A  52
ALA A  47
TYR A  48
 None
 1.28A 3qxvE-5czrA:
undetectable		 3qxvE-5czrA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		4 / 8 ASP A 152
VAL A 211
PHE A 157
LEU A 167
 None
 0.88A 4f8hA-5czrA:
undetectable
4f8hB-5czrA:
undetectable		 4f8hA-5czrA:
23.69
4f8hB-5czrA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		4 / 8 ASP A 152
VAL A 211
PHE A 157
LEU A 167
 None
 0.88A 4f8hB-5czrA:
undetectable
4f8hC-5czrA:
undetectable		 4f8hB-5czrA:
23.69
4f8hC-5czrA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		4 / 8 ASP A 152
VAL A 211
PHE A 157
LEU A 167
 None
 0.87A 4f8hC-5czrA:
undetectable
4f8hD-5czrA:
undetectable		 4f8hC-5czrA:
23.69
4f8hD-5czrA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		4 / 8 ASP A 152
VAL A 211
PHE A 157
LEU A 167
 None
 0.88A 4f8hD-5czrA:
undetectable
4f8hE-5czrA:
undetectable		 4f8hD-5czrA:
23.69
4f8hE-5czrA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		4 / 8 VAL A 211
PHE A 157
LEU A 167
ASP A 152
 None
 0.88A 4f8hA-5czrA:
undetectable
4f8hE-5czrA:
undetectable		 4f8hA-5czrA:
23.69
4f8hE-5czrA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		4 / 6 ASP A  99
ALA A 136
THR A 198
TYR A 193
 CA  A1002 ( 2.7A)
CA  A1004 (-4.4A)
None
None
 1.36A 4w5qA-5czrA:
undetectable		 4w5qA-5czrA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		4 / 6 ASP A  99
ALA A 136
THR A 198
TYR A 193
 CA  A1002 ( 2.7A)
CA  A1004 (-4.4A)
None
None
 1.38A 4w5rA-5czrA:
undetectable		 4w5rA-5czrA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		4 / 6 ASP A  99
ALA A 136
THR A 198
TYR A 193
 CA  A1002 ( 2.7A)
CA  A1004 (-4.4A)
None
None
 1.35A 4w5tA-5czrA:
undetectable		 4w5tA-5czrA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		4 / 6 ASP A  99
ALA A 136
THR A 198
TYR A 193
 CA  A1002 ( 2.7A)
CA  A1004 (-4.4A)
None
None
 1.35A 4z4cA-5czrA:
undetectable		 4z4cA-5czrA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		4 / 6 ASP A  99
ALA A 136
THR A 198
TYR A 193
 CA  A1002 ( 2.7A)
CA  A1004 (-4.4A)
None
None
 1.37A 4z4fA-5czrA:
undetectable		 4z4fA-5czrA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		4 / 5 ASP A  99
ALA A 136
THR A 198
TYR A 193
 CA  A1002 ( 2.7A)
CA  A1004 (-4.4A)
None
None
 1.35A 4z4gA-5czrA:
undetectable		 4z4gA-5czrA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		4 / 5 ASP A  99
ALA A 136
THR A 198
TYR A 193
 CA  A1002 ( 2.7A)
CA  A1004 (-4.4A)
None
None
 1.35A 4z4hA-5czrA:
undetectable		 4z4hA-5czrA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		4 / 6 ASP A  99
ALA A 136
THR A 198
TYR A 193
 CA  A1002 ( 2.7A)
CA  A1004 (-4.4A)
None
None
 1.34A 4z4iA-5czrA:
undetectable		 4z4iA-5czrA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		4 / 4 TYR A 180
GLY A 169
SER A 170
LEU A 171
 None
 1.36A 5bphC-5czrA:
undetectable		 5bphC-5czrA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 5czr CADHERIN-RELATED
FAMILY MEMBER 2
(Homo
sapiens) 		4 / 8 LEU A  65
ALA A  51
VAL A  94
TYR A  48
 None
 0.94A 5nu7A-5czrA:
undetectable		 5nu7A-5czrA:
20.43