SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5czv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 5czv NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 3
(Homo
sapiens) 		3 / 3 TYR A1453
ARG A1426
GLN A1605
 None
 0.89A 1tw4A-5czvA:
undetectable		 1tw4A-5czvA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5czv NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 3
(Homo
sapiens) 		5 / 11 ALA A1604
LEU A1543
LEU A1515
VAL A1629
ILE A1538
 None
 1.11A 3jw5A-5czvA:
undetectable		 3jw5A-5czvA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5czv NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 3
(Homo
sapiens) 		6 / 10 ALA A1604
LEU A1543
LEU A1515
VAL A1629
ILE A1538
LEU A1620
 None
 1.14A 3jw5B-5czvA:
undetectable		 3jw5B-5czvA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 5czv NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 3
(Homo
sapiens) 		4 / 4 GLY A1422
ASP A1609
GLY A1631
THR A1516
 None
 1.06A 3k4vC-5czvA:
undetectable		 3k4vC-5czvA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5czv NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 3
(Homo
sapiens) 		4 / 7 TYR A1624
PHE A1622
ALA A1537
GLY A1494
 None
 0.91A 5uxdA-5czvA:
undetectable		 5uxdA-5czvA:
22.93