SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5czy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		4 / 6 PHE A 497
VAL A 455
ALA A 467
LEU A 471
 None
 0.73A 1e7bB-5czyA:
undetectable		 1e7bB-5czyA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		4 / 5 ASP A 526
GLU A 525
LEU A 531
LEU A 528
 None
 1.11A 1np1A-5czyA:
undetectable		 1np1A-5czyA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		5 / 12 ILE A  92
ILE A 181
LEU A 209
VAL A 214
ILE A 147
 None
 1.02A 1oipA-5czyA:
undetectable		 1oipA-5czyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		4 / 7 THR A 262
TYR A 263
LEU A 315
GLN A 266
 None
 1.02A 1qzrA-5czyA:
undetectable		 1qzrA-5czyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		4 / 7 THR A 262
TYR A 263
LEU A 315
GLN A 266
 None
 1.00A 1qzrB-5czyA:
undetectable		 1qzrB-5czyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		4 / 5 ILE A 107
ILE A 193
ILE A 181
LEU A  96
 None
 0.77A 1zgyA-5czyA:
undetectable		 1zgyA-5czyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		3 / 3 ASN A 232
TYR A 446
SER A 198
 None
 0.88A 2gvcB-5czyA:
undetectable		 2gvcB-5czyA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		3 / 3 ASN A 232
TYR A 446
SER A 198
 None
 0.85A 2gvcE-5czyA:
undetectable		 2gvcE-5czyA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		4 / 5 LEU A 353
ASP A 314
ALA A 358
ILE A 292
 None
 1.18A 2qhfA-5czyA:
undetectable		 2qhfA-5czyA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		4 / 8 GLN A 239
ASP A 409
TYR A 233
SER A 241
 None
 1.24A 2xz5C-5czyA:
undetectable
2xz5D-5czyA:
undetectable		 2xz5C-5czyA:
17.49
2xz5D-5czyA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		3 / 3 MET A 456
MET A 483
PHE A 492
 None
 1.35A 3gn8A-5czyA:
undetectable		 3gn8A-5czyA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA303_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		4 / 4 GLN A 199
GLN A 363
GLY A 368
HIS A 369
 None
 1.21A 3huoA-5czyA:
undetectable		 3huoA-5czyA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		4 / 8 ILE A 193
ILE A 223
PHE A 134
GLY A 252
 None
 0.97A 4hdlA-5czyA:
undetectable		 4hdlA-5czyA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		4 / 4 ILE A  98
VAL A 117
VAL A 119
ARG A 131
 None
 0.94A 4m6tA-5czyA:
undetectable		 4m6tA-5czyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		5 / 12 ASP A 406
SER A 198
ASP A 409
PHE A 246
ASP A 197
 GOL  A 601 (-4.9A)
None
None
None
None
 1.47A 4pevA-5czyA:
undetectable		 4pevA-5czyA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		5 / 12 ASP A 406
SER A 198
ASP A 409
PHE A 246
ASP A 197
 GOL  A 601 (-4.9A)
None
None
None
None
 1.39A 4pevC-5czyA:
undetectable		 4pevC-5czyA:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		12 / 12 LEU A 125
GLY A 130
ARG A 131
SER A 171
TYR A 192
ASN A 194
PHE A 195
TYR A 233
GLU A 238
TYR A 244
TYR A 245
LEU A 247
 None
SAM  A 603 ( 3.8A)
None
SAM  A 603 (-3.1A)
SAM  A 603 (-4.8A)
SAM  A 603 (-3.2A)
None
None
SAM  A 603 (-3.0A)
SAM  A 603 (-3.9A)
GOL  A 604 (-4.0A)
SAM  A 603 (-4.0A)
 0.01A 5czyA-5czyA:
60.2		 5czyA-5czyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		3 / 3 GLN A 362
THR A 336
ASP A 314
 None
 0.87A 5k9dA-5czyA:
undetectable		 5k9dA-5czyA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		3 / 3 LYS A 186
ASP A 182
ILE A  98
 None
 0.91A 5kc4E-5czyA:
undetectable		 5kc4E-5czyA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		4 / 5 VAL A 217
THR A 190
ASN A 188
ASP A 112
 None
 1.23A 5m0iB-5czyA:
undetectable		 5m0iB-5czyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		3 / 3 HIS A 356
GLU A 355
TRP A 352
 None
 0.84A 5odiD-5czyA:
undetectable		 5odiD-5czyA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		3 / 3 HIS A 356
GLU A 355
TRP A 352
 None
 0.87A 5odqD-5czyA:
undetectable		 5odqD-5czyA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5czy LEGIONELLA EFFECTOR
LEGAS4
(Legionella
pneumophila) 		3 / 3 HIS A 356
GLU A 355
TRP A 352
 None
 0.81A 5odrD-5czyA:
undetectable		 5odrD-5czyA:
13.10