SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d19'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5d19 TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 PHE A  74
ALA A 138
ILE A 137
VAL A 128
ALA A  70
 None
 1.33A 1vq1A-5d19A:
undetectable		 1vq1A-5d19A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5d19 TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 199
LEU A  98
VAL A 175
GLY A 174
 None
 0.93A 2po5A-5d19A:
undetectable		 2po5A-5d19A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 5d19 TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 200
GLN A  89
ARG A  93
 None
 0.99A 2w3bB-5d19A:
undetectable		 2w3bB-5d19A:
20.42