SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d1p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 GLU A  66
LYS A 180
GLU A  64
SER A  38
 None
 1.10A 1knyA-5d1pA:
undetectable
1knyB-5d1pA:
undetectable		 1knyA-5d1pA:
21.08
1knyB-5d1pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 LEU A 134
VAL A 174
VAL A 103
GLY A 150
LEU A 200
 None
 1.22A 1lwcA-5d1pA:
undetectable		 1lwcA-5d1pA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 PHE A  46
GLY A 120
GLY A  56
ILE A  68
THR A 117
 None
 0.96A 1nv8B-5d1pA:
undetectable		 1nv8B-5d1pA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 177
LEU A 194
LEU A 200
ILE A 105
THR A 113
 None
 1.23A 1tw4B-5d1pA:
undetectable		 1tw4B-5d1pA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 PRO A 165
GLY A 168
PRO A 169
GLY A 154
 None
 0.84A 1usqB-5d1pA:
undetectable		 1usqB-5d1pA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 PRO A 165
GLY A 168
PRO A 169
GLY A 154
 None
 0.83A 1usqC-5d1pA:
undetectable		 1usqC-5d1pA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 PRO A 165
GLY A 168
PRO A 169
GLY A 154
 None
 0.83A 1usqD-5d1pA:
undetectable		 1usqD-5d1pA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 PRO A 165
GLY A 168
PRO A 169
GLY A 154
 None
 0.84A 1usqE-5d1pA:
undetectable		 1usqE-5d1pA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 LEU A 134
VAL A 174
VAL A 103
GLY A 150
LEU A 200
 None
 1.25A 2hnyA-5d1pA:
undetectable		 2hnyA-5d1pA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 PRO A 165
GLY A 168
PRO A 169
GLY A 154
 None
 0.86A 2jkjA-5d1pA:
undetectable		 2jkjA-5d1pA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 PRO A 165
GLY A 168
PRO A 169
GLY A 154
 None
 0.87A 2jkjB-5d1pA:
undetectable		 2jkjB-5d1pA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 PRO A 165
GLY A 168
PRO A 169
GLY A 154
 None
 0.87A 2jkjC-5d1pA:
undetectable		 2jkjC-5d1pA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 PRO A 165
GLY A 168
PRO A 169
GLY A 154
 None
 0.84A 2jklB-5d1pA:
undetectable		 2jklB-5d1pA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A 342
LEU A 345
ILE A 361
ARG A 363
 None
 1.16A 2rlfB-5d1pA:
undetectable
2rlfC-5d1pA:
undetectable		 2rlfB-5d1pA:
7.94
2rlfC-5d1pA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ILE A  13
PHE A  46
LEU A 108
ILE A  59
MET A  41
 None
 1.30A 2xkwB-5d1pA:
undetectable		 2xkwB-5d1pA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 GLY A 120
GLY A  70
GLY A  56
 None
 0.43A 3bogD-5d1pA:
undetectable		 3bogD-5d1pA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 LEU A 134
VAL A 174
VAL A 103
GLY A 150
LEU A 200
 None
 1.25A 3qipA-5d1pA:
undetectable		 3qipA-5d1pA:
20.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QWU_A_ADNA501_1
(DNA LIGASE)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		10 / 12 ILE A  74
GLU A  95
ASN A 102
ARG A 118
GLU A 151
PHE A 175
VAL A 203
VAL A 234
LYS A 236
LYS A 246
 APK  A  97 (-4.3A)
APK  A  97 ( 4.2A)
APK  A  97 ( 3.8A)
SO4  A 502 (-3.2A)
APK  A  97 ( 3.0A)
APK  A  97 ( 3.5A)
APK  A  97 ( 4.7A)
APK  A  97 ( 4.3A)
APK  A  97 ( 3.3A)
SO4  A 501 ( 2.7A)
 0.47A 3qwuA-5d1pA:
39.9		 3qwuA-5d1pA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QWU_B_ADNB501_1
(DNA LIGASE)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		9 / 11 ILE A  74
GLU A  95
ASN A 102
ARG A 118
GLU A 151
PHE A 175
VAL A 203
VAL A 234
LYS A 236
 APK  A  97 (-4.3A)
APK  A  97 ( 4.2A)
APK  A  97 ( 3.8A)
SO4  A 502 (-3.2A)
APK  A  97 ( 3.0A)
APK  A  97 ( 3.5A)
APK  A  97 ( 4.7A)
APK  A  97 ( 4.3A)
APK  A  97 ( 3.3A)
 0.39A 3qwuB-5d1pA:
40.0		 3qwuB-5d1pA:
30.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		6 / 11 PHE A 172
VAL A 174
PHE A 140
ILE A 105
LEU A 195
PHE A 139
 None
 1.44A 3t3rA-5d1pA:
undetectable		 3t3rA-5d1pA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 PHE A 172
VAL A 174
PHE A 140
ILE A 105
PHE A 139
 None
 1.43A 3t3rC-5d1pA:
undetectable		 3t3rC-5d1pA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 GLU A 151
ILE A 153
ASN A 157
GLU A 132
 APK  A  97 ( 3.0A)
None
None
None
 1.12A 4ejwB-5d1pA:
undetectable		 4ejwB-5d1pA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 ASP A 237
SER A 239
ARG A  91
GLU A 189
 None
 1.22A 4eysA-5d1pA:
undetectable		 4eysA-5d1pA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 MET A 235
MET A  98
TYR A 247
 None
APK  A  97 ( 4.2A)
None
 1.24A 4p6xI-5d1pA:
undetectable		 4p6xI-5d1pA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 VAL A 347
LEU A 351
ARG A 363
THR A 325
ILE A 327
 None
 1.25A 4ubsA-5d1pA:
undetectable		 4ubsA-5d1pA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.28A 5ad6A-5d1pA:
undetectable
5ad6B-5d1pA:
undetectable		 5ad6A-5d1pA:
23.79
5ad6B-5d1pA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FW0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.26A 5fw0A-5d1pA:
undetectable
5fw0B-5d1pA:
undetectable		 5fw0A-5d1pA:
23.79
5fw0B-5d1pA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 LEU A 134
VAL A 174
VAL A 103
GLY A 150
LEU A 200
 None
 1.21A 5hbmA-5d1pA:
2.1		 5hbmA-5d1pA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 GLU A 310
PRO A 307
ILE A 305
LEU A 309
 None
 1.11A 5m45A-5d1pA:
undetectable		 5m45A-5d1pA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 GLU A 310
PRO A 307
ILE A 305
LEU A 309
 None
 1.15A 5m45D-5d1pA:
undetectable		 5m45D-5d1pA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 GLU A 310
PRO A 307
ILE A 305
LEU A 309
 None
 1.14A 5m45G-5d1pA:
undetectable		 5m45G-5d1pA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 GLU A 310
PRO A 307
ILE A 305
LEU A 309
 None
 1.17A 5m45J-5d1pA:
undetectable		 5m45J-5d1pA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.27A 5unuA-5d1pA:
undetectable
5unuB-5d1pA:
undetectable		 5unuA-5d1pA:
23.79
5unuB-5d1pA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.20A 5unwA-5d1pA:
undetectable
5unwB-5d1pA:
undetectable		 5unwA-5d1pA:
23.79
5unwB-5d1pA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 MET A  98
ARG A 192
VAL A 234
GLU A 151
 APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
APK  A  97 ( 3.0A)
 1.33A 5unxA-5d1pA:
2.1
5unxB-5d1pA:
undetectable		 5unxA-5d1pA:
23.79
5unxB-5d1pA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.22A 5uo0A-5d1pA:
2.1
5uo0B-5d1pA:
undetectable		 5uo0A-5d1pA:
23.79
5uo0B-5d1pA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.23A 5uo3A-5d1pA:
undetectable
5uo3B-5d1pA:
undetectable		 5uo3A-5d1pA:
23.21
5uo3B-5d1pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO6_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.25A 5uo6A-5d1pA:
undetectable
5uo6B-5d1pA:
undetectable		 5uo6A-5d1pA:
23.21
5uo6B-5d1pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 MET A  98
ARG A 192
VAL A 234
GLU A 151
 APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
APK  A  97 ( 3.0A)
 1.23A 5uo7A-5d1pA:
undetectable
5uo7B-5d1pA:
undetectable		 5uo7A-5d1pA:
23.21
5uo7B-5d1pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.24A 5uo7A-5d1pA:
undetectable
5uo7B-5d1pA:
undetectable		 5uo7A-5d1pA:
23.21
5uo7B-5d1pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.26A 5vuiA-5d1pA:
undetectable
5vuiB-5d1pA:
undetectable		 5vuiA-5d1pA:
23.79
5vuiB-5d1pA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.23A 5vv3A-5d1pA:
undetectable
5vv3B-5d1pA:
undetectable		 5vv3A-5d1pA:
23.21
5vv3B-5d1pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 VAL A 114
TYR A  60
HIS A 121
GLU A 337
 None
 1.21A 6gneB-5d1pA:
undetectable		 6gneB-5d1pA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 GLY A 229
LEU A 225
TYR A 164
GLN A 162
 None
 1.20A 6ji6A-5d1pA:
undetectable		 6ji6A-5d1pA:
18.96