SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d1r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  66
VAL A  22
ILE A  42
VAL A  53
ILE A  17
 None
 1.40A 1gebA-5d1rA:
undetectable		 1gebA-5d1rA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		4 / 7 TRP A  91
THR A 224
LEU A 226
LEU A 231
 None
 0.92A 1gtiA-5d1rA:
undetectable		 1gtiA-5d1rA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		4 / 7 TRP A  91
THR A 224
LEU A 226
LEU A 231
 None
 1.01A 1gtiD-5d1rA:
undetectable		 1gtiD-5d1rA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		4 / 7 TRP A  91
THR A 224
LEU A 226
LEU A 231
 None
 0.99A 1gtiE-5d1rA:
undetectable		 1gtiE-5d1rA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		3 / 3 ALA A  97
THR A  86
PHE A 142
 None
None
56S  A 305 (-4.1A)
 0.53A 2c6nB-5d1rA:
undetectable		 2c6nB-5d1rA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  99
ALA A  97
VAL A 196
GLY A 104
ASP A 221
 None
 1.06A 2f16K-5d1rA:
undetectable
2f16L-5d1rA:
undetectable		 2f16K-5d1rA:
19.76
2f16L-5d1rA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  99
ALA A  97
VAL A 196
GLY A 104
ASP A 221
 None
 1.04A 2f16Y-5d1rA:
undetectable
2f16Z-5d1rA:
undetectable		 2f16Y-5d1rA:
19.76
2f16Z-5d1rA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 133
PHE A 170
GLY A 140
PHE A 143
 None
None
None
56S  A 305 ( 3.5A)
 0.76A 3ko0O-5d1rA:
undetectable
3ko0Q-5d1rA:
undetectable		 3ko0O-5d1rA:
17.07
3ko0Q-5d1rA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 116
VAL A 138
VAL A 134
TRP A 105
TYR A 117
 None
 1.32A 3m8pA-5d1rA:
0.0
3m8pB-5d1rA:
undetectable		 3m8pA-5d1rA:
16.40
3m8pB-5d1rA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 116
VAL A 138
VAL A 134
TRP A 105
TYR A 117
 None
 1.35A 3medA-5d1rA:
undetectable
3medB-5d1rA:
undetectable		 3medA-5d1rA:
16.43
3medB-5d1rA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		6 / 12 ALA A  99
ALA A  97
VAL A 196
ALA A 106
GLY A 104
ASP A 221
 None
 1.14A 3mg0Y-5d1rA:
undetectable
3mg0Z-5d1rA:
undetectable		 3mg0Y-5d1rA:
19.76
3mg0Z-5d1rA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 PRO A 180
PHE A 179
LEU A 192
VAL A 228
ALA A 148
 None
None
56S  A 305 ( 4.3A)
None
None
 1.19A 4a84A-5d1rA:
undetectable		 4a84A-5d1rA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		3 / 3 PHE A 142
ASP A 144
ARG A  83
 56S  A 305 (-4.1A)
None
None
 0.84A 4eahF-5d1rA:
undetectable		 4eahF-5d1rA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		3 / 3 PHE A 142
ASP A 144
ARG A  83
 56S  A 305 (-4.1A)
None
None
 0.83A 4eahG-5d1rA:
undetectable		 4eahG-5d1rA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 100
ASP A 144
GLY A 149
THR A 224
 None
 1.06A 4l1aB-5d1rA:
undetectable		 4l1aB-5d1rA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 5 PHE A 179
ILE A 155
GLY A 181
ILE A 146
LEU A 157
 None
 1.38A 5dzkB-5d1rA:
undetectable
5dzkI-5d1rA:
undetectable
5dzkW-5d1rA:
undetectable		 5dzkB-5d1rA:
24.90
5dzkI-5d1rA:
25.91
5dzkW-5d1rA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		3 / 3 THR A  65
PRO A 127
ASP A 129
 None
 0.90A 5l8dB-5d1rA:
undetectable		 5l8dB-5d1rA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		3 / 3 THR A  65
PRO A 127
ASP A 129
 None
 0.90A 5mwuB-5d1rA:
undetectable		 5mwuB-5d1rA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 227
PHE A 190
PHE A 143
PHE A 177
 None
56S  A 305 (-3.0A)
56S  A 305 ( 3.5A)
None
 0.97A 6h7lA-5d1rA:
undetectable		 6h7lA-5d1rA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 227
PHE A 190
PHE A 143
PHE A 177
 None
56S  A 305 (-3.0A)
56S  A 305 ( 3.5A)
None
 0.98A 6h7lB-5d1rA:
undetectable		 6h7lB-5d1rA:
16.32